Impact of high-fat diet on lifespan, metabolism, fecundity and behavioral senescence in Drosophila

Liao, Sifang; Amcoff, Mirjam; Nässel, Dick R.

doi:10.1016/j.ibmb.2020.103495

Cited by 55 publications

(64 citation statements)

References 101 publications

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“…Further, given its eating sources (mostly rotting fruits), the fruit-fly needs a powerful detoxification system that involves the gut, the FB and the oenocytes ( Yang et al, 2007 ; Iredale, 2010 ; Huang et al, 2019 ). Over the past two decades, several studies on metabolic hepatic dysfunctions have taken advantage of the fly model ( Hader et al, 2003 ; Villanueva et al, 2019 ; Ghosh et al, 2020 ; Hofbauer et al, 2020 ; Liao et al, 2020 ) to describe the functional activities of molecules relevant for human pathologies ( Perrimon et al, 2016 ; Ugur et al, 2016 ; Heier and Kuhnlein, 2018 ; Hmeljak and Justice, 2019 ).…”

Section: The Fruit-fly Modelmentioning

confidence: 99%

Drosophila melanogaster: A Powerful Tiny Animal Model for the Study of Metabolic Hepatic Diseases

Moraes

Montagne

2021

Front. Physiol.

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Animal experimentation is limited by unethical procedures, time-consuming protocols, and high cost. Thus, the development of innovative approaches for disease treatment based on alternative models in a fast, safe, and economic manner is an important, yet challenging goal. In this paradigm, the fruit-fly Drosophila melanogaster has become a powerful model for biomedical research, considering its short life cycle and low-cost maintenance. In addition, biological processes are conserved and homologs of ∼75% of human disease-related genes are found in the fruit-fly. Therefore, this model has been used in innovative approaches to evaluate and validate the functional activities of candidate molecules identified via in vitro large-scale analyses, as putative agents to treat or reverse pathological conditions. In this context, Drosophila offers a powerful alternative to investigate the molecular aspects of liver diseases, since no effective therapies are available for those pathologies. Non-alcoholic fatty liver disease is the most common form of chronic hepatic dysfunctions, which may progress to the development of chronic hepatitis and ultimately to cirrhosis, thereby increasing the risk for hepatocellular carcinoma (HCC). This deleterious situation reinforces the use of the Drosophila model to accelerate functional research aimed at deciphering the mechanisms that sustain the disease. In this short review, we illustrate the relevance of using the fruit-fly to address aspects of liver pathologies to contribute to the biomedical area.

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Section: The Fruit-fly Modelmentioning

confidence: 99%

Drosophila melanogaster: A Powerful Tiny Animal Model for the Study of Metabolic Hepatic Diseases

Moraes

Montagne

2021

Front. Physiol.

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“…Manduca sexta larvae reared on HFD were found to possess higher lipid content in their fat body ( Cambron et al, 2019 ). Various studies from D. melanogaster also revealed that HFD leads to increased TG levels in adults ( Birse et al, 2010 ; Heinrichsen and Haddad, 2012 ; Heinrichsen et al, 2014 ; Woodcock et al, 2015 ; Trindade de Paula et al, 2016 ; Jung et al, 2018 ; Rivera et al, 2019 ; Liao et al, 2021 ). The HFD-induced TG accumulation observed here and by others is not surprising as excess dietary fatty acids are converted to TG for storage in fat body lipid droplets ( Carvalho et al, 2012 ; Toprak et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, PBD also led to lower (third instar larvae) or similar weights (fifth instar larvae or pupa); However, different PBDs might lead to different outcomes. The contradictory results on body weight, size, or mass-diet interaction in the literature are likely to be related to multiple factors, such as the source and percentage of fats ( Fernando-Warnakulasuriya et al, 1988 ; Trindade de Paula et al, 2016 ; Cambron et al, 2019 ; Liao et al, 2021 ) or carbohydrates ( Musselman et al, 2011 , 2019 ) used in the diets.…”

Section: Discussionmentioning

confidence: 99%

“…It can also be manipulated for different phenotypes (obese, lean, Type I or Type II diabetes, etc.) by artificial diets with different fat or carbohydrate levels ( Baker and Thummel, 2007 ; Buch et al, 2008 ; Birse et al, 2010 ; Musselman et al, 2011 ; Heinrichsen and Haddad, 2012 ; Na et al, 2013 ; Liao et al, 2021 ). More importantly, many of the disease-associated genes are also conserved in Drosophila ( Reiter et al, 2001 ; Musselman and Kühnlein, 2018 ; Chatterjee and Perrimon, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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What You Eat Matters: Nutrient Inputs Alter the Metabolism and Neuropeptide Expression in Egyptian Cotton Leaf Worm, Spodoptera littoralis (Lepidoptera: Noctuidae)

et al. 2021

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Graphical AbstractThe parameters examined in Spodoptera littoralis larvae in response to four different diets, high-fat, high-sugar, calcium-rich and plant-based are shown starting with the developmental duration, weight, triglyceride and trehalose levels, lipid droplet structure, and finally with expression of four neuropeptide genes encoding adipokinetic hormone (AKH), insulin-like peptide 1 (ILP1), insulin-like peptide 2 (ILP2) and short neuropeptide F (sNPF).

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“…In addition, an enhanced AKH action resulted in a prolonged lifespan of water-sensing mutant female flies [ 78 ]. A recent study also reported a longer median lifespan of female AKH mutant Drosophila compared to control flies when fed on a high fat diet or normal diet [ 79 ]. All in all, only subtle physiological effects (including no clear effect of fecundity) and changes in the behavior and lipid status were observed during the aging of the AKH mutant [ 66 ].…”

Section: Activities Of the Akh/akhr Signaling System In Drosophilamentioning

confidence: 99%

GnRH-Related Neurohormones in the Fruit Fly Drosophila melanogaster

Ben-Menahem

2021

IJMS

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Genomic and phylogenetic analyses of various invertebrate phyla revealed the existence of genes that are evolutionarily related to the vertebrate’s decapeptide gonadotropin-releasing hormone (GnRH) and the GnRH receptor genes. Upon the characterization of these gene products, encoding peptides and putative receptors, GnRH-related peptides and their G-protein coupled receptors have been identified. These include the adipokinetic hormone (AKH) and corazonin (CRZ) in insects and their cognate receptors that pair to form bioactive signaling systems, which network with additional neurotransmitters/hormones (e.g., octopamine and ecdysone). Multiple studies in the past 30 years have identified many aspects of the biology of these peptides that are similar in size to GnRH and function as neurohormones. This review briefly describes the main activities of these two neurohormones and their receptors in the fruit fly Drosophila melanogaster. The similarities and differences between Drosophila AKH/CRZ and mammalian GnRH signaling systems are discussed. Of note, while GnRH has a key role in reproduction, AKH and CRZ show pleiotropic activities in the adult fly, primarily in metabolism and stress responses. From a protein evolution standpoint, the GnRH/AKH/CRZ family nicely demonstrates the developmental process of neuropeptide signaling systems emerging from a putative common ancestor and leading to divergent activities in distal phyla.

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Impact of high-fat diet on lifespan, metabolism, fecundity and behavioral senescence in Drosophila

Cited by 55 publications

References 101 publications

Drosophila melanogaster: A Powerful Tiny Animal Model for the Study of Metabolic Hepatic Diseases

Drosophila melanogaster: A Powerful Tiny Animal Model for the Study of Metabolic Hepatic Diseases

What You Eat Matters: Nutrient Inputs Alter the Metabolism and Neuropeptide Expression in Egyptian Cotton Leaf Worm, Spodoptera littoralis (Lepidoptera: Noctuidae)

GnRH-Related Neurohormones in the Fruit Fly Drosophila melanogaster

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