Impact of high sucrose diets on the discrimination of spatial and object memories with overlapping features

Buyukata, Cem; Vukalo, Milijana; Xu, Tanya J.; Khore, Madhavi; Reichelt, Amy C.

doi:10.1016/j.physbeh.2018.02.027

Cited by 12 publications

(9 citation statements)

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“…However, these latest studies were carried out in adult rats and like our study, no effects were observed in this age group [ 8 , 39 ]. Even more, a recent study in young animals showed that intermittent access to a 10% sucrose solution for 2 weeks can disrupt perirhinal-dependent memory when objects have increased similarity and share multiple features [ 38 ]. In this study, female rats consumed significantly more sucrose solution than males and performed worst in the memory tasks, and the authors finally suggest that with a prolonged consumption of sucrose (more than 2 weeks) it could also further decrease the NOR performance in males.…”

Section: Discussionmentioning

confidence: 99%

“…In female rats, fructose consumption also alters NOR test performance with retention intervals of 2 h and 24 h [ 30 ]. Furthermore, intermittent sucrose consumption in juvenile animals affects NOR only when the objects shared multiple characteristics [ 33 , 38 ], whereas in adults, continuous sucrose consumption does not affect NOR [ 8 , 39 ]. Together, these data indicate that the amount of sucrose consumed and the age of exposure to this consumption are probably related to the cognitive deficits found.…”

Section: Introductionmentioning

confidence: 99%

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Long-Term Memory Function Impairments following Sucrose Exposure in Juvenile versus Adult Rats

et al. 2022

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We previously described that excessive consumption of sucrose during youth produces fear memory and anxiety-like behavior in adulthood. Here, we evaluated whether high cognitive function is also affected by studying early sucrose consumption in object recognition memory (NOR). Male Sprague Dawley rats were tested for short-term, long-term, and consolidated NOR after 25 days of unlimited sucrose access in juvenile (PD 25–50) or adult age (PD 75–100). All rats spent equal time exploring the two objects during the sample phase T1. When animals were exposed for 2 h, 24 h, or 7 days to a copy of the objects presented in T1 and a novel object, the sucrose-exposed juvenile group failed to distinguish between the familiar and the novel objects in contrast with the rest of the groups. Sucrose-exposed animals developed hypertriglyceridemia and glucose intolerance, but juvenile animals showed increased fasting glycemia and sustained the glucose intolerance longer. Moreover, sucrose decreased hippocampal proBDNF expression in juveniles while it was increased in adults, and sucrose also increased RAGE expression in adults. The NOR exploration ratio correlated negatively with basal glycemia and positively with proBDNF. Taken together, these data suggest that sucrose-induced alterations in glucose metabolism may contribute to a long-term decline in proBDNF and impaired recognition memory.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long-Term Memory Function Impairments following Sucrose Exposure in Juvenile versus Adult Rats

et al. 2022

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“…In contrast to these well-known metabolic effects, little is known about how chronic sucrose consumption alters behaviour and the brain (Rada et al 2005, Reichelt et al 2016. Chronic sugar intake in rodents impairs shortterm memory (Buyukata et al 2018), spatial memory (Beilharz et al 2016, Buyukata et al 2018, and goaldirected behaviour (Sharpe et al 2016). The underlying neural mechanisms are not clear but might include changes to the mesocorticolimbic system, a circuit comprised of dopamine (DA) synthesizing neurons in the ventral tegmental area (VTA) and DA-sensitive neurons in the nucleus accumbens (NAc), medial prefrontal cortex (mPFC), hippocampus (HPC), and other areas (Ikemoto 2007).…”

Section: Introductionmentioning

confidence: 99%

Sucrose consumption alters steroid and dopamine signalling in the female rat brain

Tobiansky

Kachkovski

Enos

et al. 2020

Journal of Endocrinology

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Sucrose consumption is associated with type 2 diabetes, cardiovascular disease, and cognitive deficits. Sucrose intake during pregnancy might have particularly prominent effects on metabolic, endocrine, and neural physiology. It remains unclear how consumption of sucrose affects parous females, especially in brain circuits that mediate food consumption and reward processing. Here, we examine whether a human-relevant level of sucrose before, during, and after pregnancy (17–18 weeks total) influences metabolic and neuroendocrine physiology in female rats. Females were fed either a control diet or a macronutrient-matched, isocaloric sucrose diet (25% of kcal from sucrose). Metabolically, sucrose impairs glucose tolerance, increases liver lipids, and increases a marker of adipose inflammation, but has no effect on body weight or overall visceral adiposity. Sucrose also decreases corticosterone levels in serum but not in the brain. Sucrose increases progesterone levels in serum and in the brain and increases the brain:serum ratio of progesterone in the mesocorticolimbic system and hypothalamus. These data suggest a dysregulation of systemic and local steroid signalling. Moreover, sucrose decreases tyrosine hydroxylase (TH), a catecholamine-synthetic enzyme, in the medial prefrontal cortex. Finally, sucrose consumption alters the expression pattern of FOSB, a marker of phasic dopamine signalling, in the nucleus accumbens. Overall, chronic consumption of sucrose at a human-relevant level alters metabolism, steroid levels, and brain dopamine signalling in a female rat model.

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“…However, a recent study has indicated that high sucrose diets can disrupt object recognition performance when objects have increased similarity and share multiple features (Buyukata et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Sucrose or sucrose and caffeine differentially impact memory and anxiety-like behaviours, and alter hippocampal parvalbumin and doublecortin

Reichelt

2018

Neuropharmacology

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Caffeinated sugar-sweetened "energy" drinks are a subset of soft drinks that are popular among young people worldwide. High sucrose diets impair cognition and alter aspects of emotional behaviour in rats, however, little is known about sucrose combined with caffeine. Rats were allocated to 2 h/day 10% sucrose (Suc), 10% sucrose plus 0.04% caffeine (CafSuc) or control (water) conditions. The addition of caffeine to sucrose appeared to increase the rewarding aspect of sucrose, as the CafSuc group consumed more solution than the Suc group. After 14 days of intermittent Suc or CafSuc access, anxiety was assessed in the elevated plus maze (EPM) prior to their daily solution access, whereby CafSuc and Suc rats spent more time in the closed arms, indicative of increased anxiety. Following daily solution access, CafSuc, but not Suc, rats showed reduced anxiety-like behaviour in the open-field. Control and CafSuc rats displayed intact place and long-term object memory, while Suc showed impaired memory performance. Sucrose reduced parvalbumin immunoreactivity in the hippocampus, but no differences were observed between Control and CafSuc conditions. Parvalbumin reactivity in the basolateral amygdala did not differ between conditions. Reduced doublecortin immunoreactivity in the dentate gyrus relative to controls was seen in the CafSuc, but not Suc, treatment conditions. These findings indicate that the addition of caffeine to sucrose attenuated cognitive deficits. However, the addition of caffeine to sucrose evoked anxiety-like responses under certain testing conditions, suggesting that frequent consumption of caffeinated energy drinks may promote emotional alterations and brain changes compared to standard soft drinks.

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Impact of high sucrose diets on the discrimination of spatial and object memories with overlapping features

Cited by 12 publications

References 45 publications

Long-Term Memory Function Impairments following Sucrose Exposure in Juvenile versus Adult Rats

Long-Term Memory Function Impairments following Sucrose Exposure in Juvenile versus Adult Rats

Sucrose consumption alters steroid and dopamine signalling in the female rat brain

Sucrose or sucrose and caffeine differentially impact memory and anxiety-like behaviours, and alter hippocampal parvalbumin and doublecortin

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