Impact of histological subtype on survival of patients with surgically-treated stage IA2–IIB cervical cancer: Adenocarcinoma versus squamous cell carcinoma

Mabuchi, Seiji; Okazawa, Makoto; Matsuo, Koji; Kawano, Mahiru; Сузукі, Осаму; Miyatake, Takashi; Enomoto, Takayuki; Kamiura, Shoji; Ogawa, Kazuhiko; Kimura, Tadashi

doi:10.1016/j.ygyno.2012.06.021

Cited by 98 publications

(73 citation statements)

References 30 publications

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“…Although histological types have been suggested as independent prognostic factors (Mabuchi, 2012;, no significant differences in OS were found in our population. In agreement with Bradbury et al we found significant correlation of OS with lymph node metastasis but not extrauterine invasion (Table III) (Bradbury, 2015), although other authors reported significant correlation of parametrial involvement with disease-free and overall survival (Jiamset, 2016 (Mao, 2016).…”

Section: Discussioncontrasting

confidence: 83%

Prevalence and Distribution of High-Risk Human Papillomavirus Genotypes in Invasive Carcinoma of the Uterine Cervix in Uruguay. An update on clinical outcome

Berois

Nozar

Greif

et al. 2017

MRAJ

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Although the causal role of Human papillomavirus (HPV) Relating to HPV, three prognostic groups were observed. The better clinical outcome was related to genotypes other than HPV16/18/45, while HPV16/18 genotypes belong to an intermediate risk group and the worse prognosis was related to HPV negative and HPV45. HPV independent tumors have been suggested as a different entity compared with virally driven ones. Improvement in knowledge of molecular pathogenesis could impact in CC patients care. In conclusion, worse prognosis was related to HPV negative and HPV45 related tumors. More research is warranted for better understanding molecular basis of virally driven or independent cervical cancer oncogenesis.

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Section: Discussioncontrasting

confidence: 83%

Prevalence and Distribution of High-Risk Human Papillomavirus Genotypes in Invasive Carcinoma of the Uterine Cervix in Uruguay. An update on clinical outcome

Berois

Nozar

Greif

et al. 2017

MRAJ

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“…In this study, women with stage IIA2 cervical cancer had a higher rate of positive LVSI than those with stage IIA1 (71.9% vs 52.5, p=0.05). Also, some studies have suggested that adenocarcinoma histology is associated with poorer outcome compared to squamous histology (Lai et al, 1999;Takeda et al, 2002;Macdonald et al, 2009;Mabuchi et al, 2012). In the current study, the higher incidence of adenocarcinoma histology in stage IIA2 cervical cancer was also demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Locoregional Spread and Survival of Stage IIA1 versus Stage IIA2 Cervical Cancer

Hongladaromp

Tantipalakorn²,

Charoenkwan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…However, there are conflicting reports in the literature about the effect of CCRT on cervical AC/ASC. Some studies have shown that CCRT is beneficial for cervical AC/ASC [20]- [23], while other studies have reported that CCRT does not improve the survival of patients with risk factors, such as lymph node metastasis [22] [23]. In this study, we showed that CCRT did not improve the survival of patients compared with either RT or CT alone, regardless of lymph node metastasis (Figure 1).…”

Section: Discussionmentioning

confidence: 47%

Outcomes and Prognostic Factors for Adenocarcinoma/Adenosquamous Carcinomas Treated with Radical Hysterectomy and Adjuvant Therapy

Yamaguchi¹,

Yamagishi²,

Nishikawa³

et al. 2014

OJOG

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How to cite this paper: Yamaguchi, M., et al. (2014) Overall survival (OS) and progression-free survival (PFS) were calculated using the Kaplan-Meier method and compared using the log-rank test. The prognostic significance of various clinical features was determined by using multivariate analysis with the Cox proportional hazards regression model. Results: Univariate analysis revealed that OS was significantly shorter in patients with lymph node metastasis and lymphovascular space invasion. Similarly, PFS was significantly shorter for patients with lymph node metastasis and parametrial invasion. Furthermore, multivariate analysis showed that lymph node metastasis was the only independent predictor for PFS (hazard ratio: 6.47, 95% confidence interval: 1.33 -31.44, p = 0.021). However, the use of adjuvant chemoradiotherapy did not have any significant effect on either OS or PFS, regardless of lymph node metastasis. Conclusions: Lymph node metastasis is an independent prognostic factor for poor survival in cervical AC/ASC patients treated with radical hysterectomy and adjuvant therapy. In addition, adjuvant chemoradiotherapy does not improve their survival, regardless of lymph node metastasis, which suggests that novel or personalized adjuvant therapeutic strategies with fewer adverse effects than existing strategies are needed.* Corresponding author. M. Yamaguchi et al.910

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Impact of histological subtype on survival of patients with surgically-treated stage IA2–IIB cervical cancer: Adenocarcinoma versus squamous cell carcinoma

Cited by 98 publications

References 30 publications

Prevalence and Distribution of High-Risk Human Papillomavirus Genotypes in Invasive Carcinoma of the Uterine Cervix in Uruguay. An update on clinical outcome

Prevalence and Distribution of High-Risk Human Papillomavirus Genotypes in Invasive Carcinoma of the Uterine Cervix in Uruguay. An update on clinical outcome

Locoregional Spread and Survival of Stage IIA1 versus Stage IIA2 Cervical Cancer

Outcomes and Prognostic Factors for Adenocarcinoma/Adenosquamous Carcinomas Treated with Radical Hysterectomy and Adjuvant Therapy

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