Impact of Hiv Infection on the Structure of New Tuberculosis Cases Detected in the City of Moscow

Bogorodskaya, Elena; Sinitsyn, Mikhail; Belilovsky, E. M.; Borisov, S. E.; Kotova, E. A.

doi:10.21292/2075-1230-2017-95-10-17-26

Cited by 13 publications

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“…No tuberculosis patients were identified in this group. Thus, the test specificity was 99.0-99.7% (20). The high effectiveness of the test in clinical practice has been confirmed by many authors (21)(22)(23).…”

Section: Discussionmentioning

confidence: 58%

Evaluation of the specificity of an intradermal test with recombinant tuberculosis allergen in Bacillus Calmette–Guérin-vaccinated healthy volunteers

et al. 2023

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IntroductionThe tuberculin skin test has significant limitations for use in individuals vaccinated with BCG. The presence in the genome of Mycobacterium tuberculosis of the RDI region, which is absent in the genome of Mycobacterium bovis BCG and most non-tuberculous mycobacteria, made it possible to develop new skin tests, which include a skin test with a recombinant tuberculosis allergen [RTA (Diaskintest®, JSC Generium, Russia)]. Diaskintest has shown high diagnostic performance in clinical trials and in conditions of high prevalence of tuberculosis infection. In 2021, the Russia was excluded from the WHO list of high TB burden countries, which makes relevant an assessment of the specificity of the RTA test under conditions of low epidemiologic risk for tuberculosis to confirm the high specificity of the test.Study objectiveTo assess the specificity of Diaskintest in the regions of the Russian Federation with low epidemiologic risk for tuberculosis.MethodsA multicenter, open-label, prospective study was conducted, which included 150 healthy volunteers aged 18–30 years old, vaccinated with BCG, who were not at risk of tuberculosis, from regions with low epidemiologic risk (Oryol region, Ryazan region, and Arkhangelsk region). During the study, 4 visits were scheduled for each participant: [Visit 0 (screening), Visit 1, Visit 2 (in 72 h) and Visit 3 (in 28 days)]. All participants, who excluded active and latent tuberculosis infection, underwent a test with RTA. To assess the safety of RTA tests, all systemic and local adverse events that occurred during 28 days were recorded. The trial was filed in the NIH clinical trials database ClinicalTrials.gov (NCT05203068).ResultsIn individuals with a negative T-SPOT.TB test, the specificity of the RTA test was 97% (95% CI: 92–99%) with a cut-off of >0 mm. The study findings confirm data 2009: 100.00 (95% CI: 94–100). When evaluating the safety of the RTA test during 28 days of follow-up, the participants did not report local and systemic adverse reactions that had a causal relationship with the RTA test.ConclusionDiaskintest is highly specific and safe, therefore it is a valuable tool as a screening test for early detection of tuberculosis.

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Section: Discussionmentioning

confidence: 58%

Evaluation of the specificity of an intradermal test with recombinant tuberculosis allergen in Bacillus Calmette–Guérin-vaccinated healthy volunteers

et al. 2023

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“…Основными причинами неблагоприятной ситуации по туберкулезу (ТБ) во всех странах являются развитие пандемии ВИЧ-инфекции и распространение ТБ с множественной лекарственной устойчивостью (МЛУ) [1][2][3][4][5][6]. Комплекс социальноэкономических факторов, влияющих на эпидемический процесс инфекционных заболеваний, включая ТБ и ВИЧ-инфекцию, также изучен достаточно основательно [7][8][9][10].…”

Section: Abstract: Hiv/tuberculosis; Risk Factors; Hiv-infection; Tubunclassified

The main risk factors and their impact on the hiv/tuberculosis epidemic

Загдын

Моисеевна²

2019

I.P. Pavlov Russian Medical Biological Herald

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With the HIV epidemic progression, an increase of HIV/tuberculosis co-infection in relation to a number of interrelated risk factors is becoming actual everywhere. The aim of the descriptive analytical study is a comprehensive and interdisciplinary assessment of risk factors that increase or decrease the spread of the dual HIV/tuberculosis infection at the current stage in the North-West of Russia, as a pilot region. Materials and Methods. Research methods included socio-demographic, economic and epidemiological analysis, ranking, correlation and expert assessment. The basis of the socio-demographic and economic analysis was information from the state statistics on the regions of North-West of Russia, of the epidemiological analysis – reporting forms of Rosstat on tuberculosis, HIV-infection and HIV/tuberculosis coinfection, including data on the economic and human resources of the tuberculosis control system, information from analytical reports on supervising activities in the regions of the North-West of Russia during 2007-2017. The correlation dependence between the studied parameters was determined by the Spearman coefficient. Results. In the North-West of Russia, there is a statistically significant relationship between the spread of HIV/tuberculosis co-infection and the epidemiological factor in general (0.627, p<0.039) and the HIV epidemic, as a mono-disease in particular (0.731, p<0.011). The tuberculosis epidemic does not play a significant role in the complex of epidemiological factors (0.332, p>0.319) and does not make a statistically significant contribution to the HIV/tuberculosis epidemic (0.127, p>0.710). The penitentiary system also has no statistically significant relation with the HIV/tuberculosis epidemic (0.233, p>0.490), however, the tuberculosis epidemic, as monoinfection (0.619, p<0.042) is significantly associated with the correctional system. Conclusion. To improve the HIV/tuberculosis epidemic situation, it is necessary to strengthen of HIV tackling measures, especially in the penitentiary system and strengthen the economic and human resources of the tuberculosis control system.

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“…По данным исследователей, вероятность заболевания туберкулезом больных ВИЧ-инфекцией в 20-37 раз выше, чем у лиц без ВИЧ-инфекции, ввиду снижения иммунологической реактивности организма и реактивации латентной туберкулезной инфекции [3,8]. В 2017 г. каждый пятый (20,9%) среди впервые выявленных и вставших на учет больной туберкулезом имел ВИЧ-инфекцию [2,4]. В Российской Федерации (РФ) выражена тенденция к росту заболеваемости ВИЧ-инфекцией, зафиксировано ее увеличение на 50% с 2007 г.…”

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Long-term comparative analysis of the main epidemiological indicators for tuberculosis in combination with HIV infection in the Udmurt Republic

Афанасьев

Russkikh

2020

Tuberk. bolezni lëgk.

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The objective of the study: to assess changes of epidemiological indicators for TB/HIV co-infection in the Udmurt Republic (UR) and the Russian Federation (RF) from 2008 to 2017 and make the prognosis for the next 5 years.Subjects and methods. The main epidemiological indicators for TB/HIV infection were retrospectively analyzed, the data were taken from annual reports of Republican TB Dispensary, Regional Center for AIDS and Infectious Diseases and Federal Research Institute for Health Organization and Informatics by the Russian Ministry of Health.Results. From 2008 to 2017, the incidence of respiratory tuberculosis both in the Russian Federation and in the Udmurt Republic decreased by 43.0%. While the incidence of HIV infection among the population of the Udmurt Republic increased by 148.5%, in the Russian Federation by 79.7%. From 2011 to 2017, the TB/HIV incidence increased in the UR by 76.6%, in the RF by 48.2%. The mortality of tuberculosis patients died of HIV infection increased by 147.6% in the RF, and by 400% in the UR. Trends in forecasts for investigated indicators of TB/HIV co-infection in the Udmurt Republic and the Russian Federation demonstrate their further growth.

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Impact of Hiv Infection on the Structure of New Tuberculosis Cases Detected in the City of Moscow

Cited by 13 publications

References 0 publications

Evaluation of the specificity of an intradermal test with recombinant tuberculosis allergen in Bacillus Calmette–Guérin-vaccinated healthy volunteers

Evaluation of the specificity of an intradermal test with recombinant tuberculosis allergen in Bacillus Calmette–Guérin-vaccinated healthy volunteers

The main risk factors and their impact on the hiv/tuberculosis epidemic

Long-term comparative analysis of the main epidemiological indicators for tuberculosis in combination with HIV infection in the Udmurt Republic

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