2022
DOI: 10.1101/2022.08.29.22279247
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Impact of HLA divergence on humoral response to SARS-CoV-2 and HBV vaccines in the liver transplantation setting

Abstract: BackgroundOrgan transplant recipients are at high risk of viral infections but show lower humoral vaccine responsiveness than immunocompetent individuals. HLA evolutionary divergence (HED) quantifies the sequence differences between homologous HLA alleles and reflects the breadth of the immunopeptidome presented to T lymphocytes.MethodsWe retrospectively investigated the impact of HED on humoral response to SARS-CoV-2 mRNA vaccine in 310 liver transplant recipients (undetectable anti-spike IgG titers considere… Show more

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