Impact of Homocysteine as a Preconceptional Screening Factor for In Vitro Fertilization and Prevention of Miscarriage with Folic Acid Supplementation Following Frozen-Thawed Embryo Transfer: A Hospital-Based Retrospective Cohort Study

Ogawa, Seiji; Ota, Kuniaki; Takahashi, Toshifumi; Yoshida, Hiroaki

doi:10.3390/nu15173730

Cited by 6 publications

(7 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Homocysteine also plays a role in reproductive health, suspected as a risk factor for pregnancy complications and birth defects [ 36 ]. Supplementation with B vitamins, particularly folic acid, has been investigated as a strategy to reduce homocysteine levels and prevent these complications.…”

Section: Discussionmentioning

confidence: 99%

Is There a Connection between Hyperhomocysteinemia and the Cardiometabolic Syndrome?

Tarcau,

Negru,

Ghitea

et al. 2024

Biomedicines

View full text Add to dashboard Cite

This study investigates the distribution of hyperhomocysteinemia and cardiovascular metabolic syndrome (SM) among participants, shedding light on their prevalence and co-occurrence within the study cohort. Through an analysis of demographic characteristics and health parameters, including age, gender, and body mass index (BMI), alongside nutritional data, correlations between these factors and health risks are explored. Results reveal a notable prevalence of hyperhomocysteinemia, with 45.3% of participants exhibiting this condition. Furthermore, 31.4% of the cohort does not present hyperhomocysteinemia or SM, while 23.3% shows SM without hyperhomocysteinemia. The study underscores gender-specific dietary recommendations due to significant variations in nutrient intake patterns. Additionally, inverse correlations between health risks like obesity, hypertension, and hypercholesterolemia and nutrient requirements highlight the need for tailored dietary interventions. Age-related changes in nutrient needs and the positive correlation between physical activity levels and certain nutrient demands further emphasize the importance of personalized dietary strategies. Variations in nutrient intake by gender, inverse correlations with health risks, and age-related changes underscore the need for tailored dietary strategies. These findings provide valuable insights for healthcare professionals in developing targeted nutritional interventions to mitigate disease risk and promote overall health and well-being.

show abstract

Section: Discussionmentioning

confidence: 99%

Is There a Connection between Hyperhomocysteinemia and the Cardiometabolic Syndrome?

Tarcau,

Negru,

Ghitea

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

“…IVF/ICSI procedures, including ovarian stimulation, oocyte retrieval, and insemination using IVF or ICSI, were performed as previously described [ 39 ]. A frozen–thawed embryo transfer (FET), typically utilizing a hormone replacement cycle, was performed as previously described [ 40 ].…”

Section: Methodsmentioning

confidence: 99%

Micronutrient Antioxidants for Men (Menevit®) Improve Sperm Function by Reducing Oxidative Stress, Resulting in Improved Assisted Reproductive Technology Outcomes

Ogawa,

Ota,

Nishizawa

et al. 2024

Antioxidants

Self Cite

View full text Add to dashboard Cite

Oxidative stress (OS) affects men’s health and impairs spermatogenesis. Micronutrient antioxidants are available for male infertility as complemental support; however, their efficacy remains debatable. This study aimed to investigate whether antioxidants can help to reduce sperm OS and improve semen analysis and quality. We included 171 male partners of couples planning to undergo assisted reproductive technology (ART). Male partners, aged 29–41 years, of couples intending to conceive were self-selected to take daily antioxidants (n = 84) containing folic acid and zinc, or not to take antioxidants (n = 52) for 6 months. We analyzed the alterations in serum oxidant levels, sperm parameters, OS, and deoxyribonucleic acid fragmentation after 3 and 6 months. Additionally, implantation, clinical pregnancy, and miscarriage rates after vitrified–warmed embryo transfer were compared between those taking antioxidants and those not taking them after 6 months. In men with high static oxidation–reduction potential (sORP), we observed a significant improvement in sperm concentration and sORP. The high-quality blastocyst rate tended to increase, and implantation and clinical pregnancy rates also significantly increased after 6 months of intervention. The micronutrient antioxidants could improve sperm function by reducing OS and improving ART outcomes. Therefore, micronutrient antioxidants may be a viable treatment option for male infertility.

show abstract

“…It also showed a strong association with low birth weight in term children, but no effect on antenatal fetal death [16]. Administering folic acid for 12 weeks in infertile patients with a history of failed in vitro fertilization or intracytoplasmic sperm injection can significantly decrease homocysteine levels (P=0.00146); there is also an inverse relationship between vitamin D3, fertility, and homocysteine [17].…”

Section: Homocysteinementioning

confidence: 99%

Strategies for Safeguarding High-Risk Pregnancies From Preterm Birth: A Narrative Review

Al Hussaini,

Almughathawi,

Alsaedi

et al. 2024

Cureus

View full text Add to dashboard Cite

Preterm birth is the delivery of a live fetus before the 37th week of gestation. Preterm birth may stem from various factors, including premature rupture of membranes, spontaneous preterm labor, or medically induced circumstances. Premature delivery can result in serious and long-lasting difficulties even for infants who survive, as it is the leading cause of death for infants under five years old. Numerous nations have implemented initiatives to detect and track pregnant women who may give birth before their due date. Numerous therapies are available to protect these at-risk groups from the devastating effects of premature delivery, given the complex nature of preterm birth risk factors.Among the preventive measures, prophylactic progesterone appears to hold significant promise, while cervical cerclage proves effective in cases of cervical insufficiency. Conversely, pessaries show no discernible beneficial effects in reducing the risk of preterm birth. Regular antenatal visits are imperative for frequent patient evaluation and screening for potential risk factors. Adopting a healthy lifestyle can influence the risk of developing preeclampsia, with regular physical activity, a fiber-rich diet, and smoking cessation serving to mitigate the risk of preterm birth. The efficacy of bed rest in preventing preterm birth remains inconclusive due to insufficient evidence. This study aims to explore various preventive strategies for averting premature birth in high-risk women.

show abstract

Impact of Homocysteine as a Preconceptional Screening Factor for In Vitro Fertilization and Prevention of Miscarriage with Folic Acid Supplementation Following Frozen-Thawed Embryo Transfer: A Hospital-Based Retrospective Cohort Study

Cited by 6 publications

References 63 publications

Is There a Connection between Hyperhomocysteinemia and the Cardiometabolic Syndrome?

Is There a Connection between Hyperhomocysteinemia and the Cardiometabolic Syndrome?

Micronutrient Antioxidants for Men (Menevit®) Improve Sperm Function by Reducing Oxidative Stress, Resulting in Improved Assisted Reproductive Technology Outcomes

Strategies for Safeguarding High-Risk Pregnancies From Preterm Birth: A Narrative Review

Contact Info

Product

Resources

About