Impact of hospital-associated anxiety and depression on the CD4 counts of naïve HIV/AIDS patients from locations in Northern Peru

Zeña-Castillo, Dina; Mezones‐Holguín, Edward; Valdiviezo-García, Glauco; La-Chira-Albán, Arnaldo; Rodríguez-Morales, Alfonso J.; Dickson-Gonzalez, Sonia M.

doi:10.1016/j.ijid.2008.06.013

Cited by 4 publications

(2 citation statements)

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“…31 A recent study has also demonstrated in a quantitative manner an inverse relationship between CD4 count and hospital-associated anxiety and depression. 32 Finally, in one of his recent review AH Miller 33 provided a comprehensive account of the multiple links between CD4 + T cells and depression, highlighting the importance of trafficking of T cells to the brain following stress as a way to reduce stress-induced anxiety-like behavior. 33 However, a direct functional association between T cells and altered emotional behavior is still missing.…”

Section: Discussionmentioning

confidence: 99%

CD4+ but not CD8+ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice

et al. 2013

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An imbalanced immune system has long been known to influence a variety of mood disorders including anxiety, obsessive-compulsive disorders and depression. In this study, we sought to model the impact of an immunocompromised state on these emotional behaviors using RAG-1−/− mice, which lack T and B cells. We also investigated the relative contribution of CD4+ or CD8+ T cells to these manifestations using RAG-1−/−/OT-II and RAG-1−/−/OT-I transgenic mice, respectively. Our results show that RAG-1−/− mice present a significant increase in digging and marble-burying activities compared with wild-type mice. Surprisingly, these anxiety-like behaviors were significantly reverted in RAG-1−/−/OT-II but not RAG-1−/−/OT-I transgenic mice. Immunodepletion experiments with anti-CD4 or anti-CD8 in C57/BL6 mice or repopulation studies in RAG-1−/− mice did not reproduce these findings. Microarray analysis of the brain of RAG-1−/− and RAG-1−/−/OT-II mice revealed a significantly different gene fingerprint, with the latter being more similar to wild-type mice than the former. Further analysis revealed nine main signaling pathways as being significantly modulated in RAG-1−/− compared with wild-type mice. Taken together, these results suggest that life-long rather than transient immunodeficient conditions influence the emotional behaviors in mice. Most interestingly, these effects seem to correlate with a specific absence of CD4+ rather than CD8+ T cells. Validation of these findings in man might provide new clues on the mechanism by which early life immune modulation might impact mood response in adults and provide a further link between immune and emotional well-being.

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Section: Discussionmentioning

confidence: 99%

CD4+ but not CD8+ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice

et al. 2013

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“…adherence to HIV medications, faster disease progression, reduction of CD4 counts, deterioration in immunological function, suicidal ideation, greater sexual risk behaviors and marital conflict (10,11,13,14,(18)(19)(20)(21)(22)(23)(24)(25)(26). In general, the prevalence rate of depression and anxiety has been estimated from 3.2-45% and from 1.27-53% among PLWHAs, respectively.…”

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confidence: 99%

Assessing the measurement invariance of the CESD-10 and Beck anxiety inventory (BAI) questionnaires across people living with HIV/AIDS and healthy people

Bagheri

Noorshargh

Shahsavar

et al. 2019

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Background Recently, extensive research has been reported the higher rate of depression and anxiety among people living with HIV/AIDS (PLWHAs) as compared to general population. However, no single study has been carried out to investigate whether this disparity is a real difference or it happens due to lack of measurement invariance. This study aims to assess the measurement invariance of the Beck Anxiety Inventory (BAI) and 10-item Centre for Epidemiological Studies Depression Scale (CESD-10) questionnaires across PLWHAs and healthy individuals.Methods One hundred and fifty PLWHAs and 500 healthy individuals filled out the Persian version of the BAI and CES-D10 questionnaires. Multi-group multiple-indicators multiple-causes model (MG-MIMIC) was used to assess measurement invariance across PLWHAs and healthy people.Results Our findings revealed that PLWHAs and healthy individuals perceived the meaning of all the items in the BAI and CESD-10 questionnaires similarly. In addition, although depression scores were significantly higher in PLWHAs as opposed to healthy individuals, no significant difference was observed in anxiety scores of these two groups.Conclusions The current study suggests that the BAI and CESD-10 are invariant measures across PLWHAs and CESD-10 which can be used for meaningful cross-group comparison. Therefore, in comparison to healthy individuals, higher depression scores of PLWHAs is a real difference. It is highly recommended that health professionals develop therapeutic interventions and psychological supports to promote the mental health of PLWHAs which alleviate their depressive symptoms.

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Assessing the measurement invariance of the 10-item Centre for Epidemiological Studies Depression Scale and Beck Anxiety Inventory questionnaires across people living with HIV/AIDS and healthy people

et al. 2021

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Background Recently, extensive research has been reported the higher rate of depression and anxiety among people living with HIV/AIDS (PLWHAs) as compared to the general population. However, no single study has been carried out to investigate whether this disparity is a real difference or it happens due to lack of measurement invariance. This study aims to assess the measurement invariance of the Beck Anxiety Inventory (BAI) and 10-item Centre for Epidemiological Studies Depression Scale (CESD-10) questionnaires across PLWHAs and healthy individuals. Methods One hundred and fifty PLWHAs and 500 healthy individuals filled out the Persian version of the BAI and CESD-10 questionnaires. Multi-group multiple-indicators multiple-causes model (MG-MIMIC) was used to assess measurement invariance across PLWHAs and healthy people. Results Our findings revealed that PLWHAs and healthy individuals perceived the meaning of all the items in the BAI and CESD-10 questionnaires similarly. In addition, although depression scores were significantly higher in PLWHAs as opposed to the healthy individuals, no significant difference was observed in anxiety scores of these two groups. Conclusions The current study suggests that the BAI and CESD-10 are invariant measures across PLWHAs and healthy people which can be used for meaningful cross-group comparison. Therefore, in comparison to healthy individuals, higher depression score of PLWHAs is a real difference. It is highly recommended that health professionals develop therapeutic interventions and psychological supports to promote the mental health of PLWHAs which alleviate their depressive symptoms.

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Impact of hospital-associated anxiety and depression on the CD4 counts of naïve HIV/AIDS patients from locations in Northern Peru

Cited by 4 publications

References 4 publications

CD4+ but not CD8+ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice

CD4+ but not CD8+ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice

Assessing the measurement invariance of the CESD-10 and Beck anxiety inventory (BAI) questionnaires across people living with HIV/AIDS and healthy people

Assessing the measurement invariance of the 10-item Centre for Epidemiological Studies Depression Scale and Beck Anxiety Inventory questionnaires across people living with HIV/AIDS and healthy people

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