Participants were a convenience sample of college women (n=384) ages 18 to 26 attending a large, public university in Southern California. An electronic self-administered survey was utilized to collect data. The theory of planned behavior provided a framework for understanding the factors associated with vaccine uptake and with post-vaccine sexual behaviors. Results: College women had good HPV/HPV vaccine knowledge. Over 90% of vaccinees and non-vaccinees knew that Pap test is still needed after the vaccination and an HPV vaccine does not protect against all STIs. Both groups also had positive attitudes toward mandatory vaccination. However, knowledge and attitudes toward the vaccine were not directly linked to the outcome predictors-intention to obtain the vaccine and vaccine uptake. While attitude toward getting vaccinated, subjective norms, and perceived behavioral control were correlated with the outcome predictors, subjective norms consistently predicted intention to obtain HPV vaccine and vaccine uptake. There were no significant differences in sexual behaviors (numbers of sexual partners in a life time, numbers of sexual partners in the past 12 months, condom use, condom use frequency) between non-vaccinees and vaccinees. The numbers of sexual partners before and after vaccination among vaccinees were also not significantly different. Conclusions: Strategies to ensure that those who are eligible for catch-up vaccination are vaccinated should include attention to college women's subjective norms. Vaccine mandatory proposal would not be unacceptable to this population and concerns that the HPV vaccine encourages unsafe sexual behaviors and practices among college aged women may be disregarded.