Impact of human papillomavirus infection on the neovaginal and vulval tissues of women who underwent surgical treatment for Mayer-Rokitansky-Kuster-Hauser syndrome

Laparoscopically Assisted Neovaginoplasty in Vaginal Agenesis: A Long-Term Outcome Study in 240 Patients

“…14 We observed no major complications even after up to 141 months after surgery in patients operated as early as 1998 whilst self-dilation is known to be associated with complications such as prolapse [16][17][18][19][20] and urinary incontinence. 21 HPV infections occurred in 7/240 (2.9%) of our patients before long-term follow-up, of whom 1 had a VAIN-2 lesion, confirming recent findings by Frega et al 22 As patients undergoing our operation develop a completely normal vaginal epithelium 9 they can be expected to have the same prevalence of HPV infection as their peers in the general population. This underscores that the need for routine Papanicolaou testing is the same as in the general population, not least because squamous cell carcinoma has been reported after a Vecchietti procedure.…”

Should we vaccinate against and test for human papillomavirus infection in adolescent girls and women with a neovagina?

“…However, HPV infection, genital warts, VAIN, VIN and vaginal cancer have all been found in women with a neovagina 12. The first symptoms of cancer of the neovagina are a clear or bloody discharge and postcoital bleeding.…”

Vaginal prevalence of human papillomavirus infections in women with uterovaginal aplasia before and after laparoscopically assisted creation of a neovagina: a prospective epidemiological observational study

“…However, most of the literature has focused on surgical outcomes after neovaginoplasty and little is known about neovagina‐associated diseases. Although, Frega et al previously reported on human papillomavirus (HPV) ‐related diseases after different techniques of neovaginoplasty, emphasising the need for HPV evaluation after surgery. Neovaginal pH and microbiological cultures provided results consistent with those of normal vaginal flora .…”

“…Although, Frega et al previously reported on human papillomavirus (HPV) ‐related diseases after different techniques of neovaginoplasty, emphasising the need for HPV evaluation after surgery. Neovaginal pH and microbiological cultures provided results consistent with those of normal vaginal flora . Different from most other surgical techniques the laparoscopically assisted neovaginoplasty creates a neovagina covered by a physiological glycogen‐secreting epithelium, histologically comparable to a normal vagina .…”

“…Neovaginal pH and microbiological cultures provided results consistent with those of normal vaginal flora . Different from most other surgical techniques the laparoscopically assisted neovaginoplasty creates a neovagina covered by a physiological glycogen‐secreting epithelium, histologically comparable to a normal vagina . We were wondering if the fact that a neovagina is ‘surgically created’ comes with a higher risk for the acquirement of an HPV infection and HPV‐related cancer and as a consequence if these women have to be even more encouraged to be vaccinated against HPV or to avoid known risk factors like smoking.…”