Impact of hypertrophic pulmonary osteoarthropathy on patients with lung cancer

Abstract

PurposeHypertrophic pulmonary osteoarthropathy (HPOA) is a rare disease that most commonly occurs secondary to lung cancer. However, the clinical significance of HPOA remains unclear. The aim of this study was to evaluate the impact of HPOA on patients with lung cancer in Taiwan.Patients and methodsData regarding lung cancer patients who demonstrated findings of HPOA on bone scintigraphy between 2010 and 2016 were retrospectively analyzed. Pathological confirmation of cases was conducted at Chiayi and Kaohsiung Chang Gang Memorial Hospital. Clinical characteristics, including gender, smoking status, histology subtype, clinical stage, and epidermal growth factor receptor (EGFR) status were investigated.ResultsWe identified 69 lung cancer patients with typical HPOA findings on bone scintigraphy. Among them, 56 were male (81.2%) and 51 were ex-smokers or current smokers (73.9%). Adenocarcinoma was the most common histology subtype (n=42, 60.9%). Of 34 patients subjected to EGFR mutation analysis, only 4 (11.8%) had EGFR-tyrosine kinase inhibitor (EGFR-TKI)-sensitive mutations.ConclusionMale, smoking, and adenocarcinoma were the most common clinical characteristics of lung cancer patients with HPOA in our cohort. However, the proportion of EGFR-TKI-sensitive mutation cases was extremely low.

Hypertrophic pulmonary osteoarthropathy due to lung cancer: A case report and literature review

“…18 We also reviewed previous articles that reported lung cancer cases associated with HPOA from other countries; the results are summarized in Table 2. 14,17,[19][20][21][22] The largest T A B L E 1 Characteristics of lung cancer cases associated with hypertrophic pulmonary osteoarthropathy in Japan study was the retrospective analysis by Qian et al 21 The study included 115 patients; 91% of the patients were men, and the median age was 62 years. Adenocarcinoma was the most common histology (48%).…”

“…We also reviewed previous articles that reported lung cancer cases associated with HPOA from other countries; the results are summarized in Table 2 14,17,19‐22 . The largest study was the retrospective analysis by Qian et al 21 The study included 115 patients; 91% of the patients were men, and the median age was 62 years.…”

“…18 We also reviewed previous articles that reported lung cancer cases associated with HPOA from other countries; the results are summarized in Table 2. 14,17,[19][20][21][22] No change 9 (9.6%)…”

Successful Treatment of <i>ROS1</i>-rearranged Lung Cancer Complicated by Hypertrophic Pulmonary Osteoarthropathy with Crizotinib Therapy

“…The common clinical characteristics of lung cancer patients with HPO are male sex, smoking history, adenocarcinoma, and advanced disease (1, 2, 5). It is unclear whether a driver oncogene is associated with the development of HPO in lung cancer patients, and there have been no previous reports of patient with ROS1 -rearranged lung cancer complicated by HPO.…”

“…It is unclear whether a driver oncogene is associated with the development of HPO in lung cancer patients, and there have been no previous reports of patient with ROS1 -rearranged lung cancer complicated by HPO. A previous study showed that the proportion of epidermal growth factor receptor ( EGFR )-positive cases among patients with HPO was extremely low (5). We are working on new project to survey the blood VEGF level and the expression of VEGF on the tumor tissue in patients with EGFR -mutated lung cancer.…”