Impact of hypo-salivation on severe tooth wear: A ten-year cohort of patients received radiotherapy for nasopharyngeal carcinoma

Lam, Walter Yu Hang; Tse, Andy K.L.; Tew, In Meei; Man, Wilson H.C.; Botelho, MG; Pow, Ehn

doi:10.1016/j.jdent.2020.103343

Cited by 7 publications

(3 citation statements)

References 46 publications

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“…In the same perspective, a 10-year cohort of survivors of nasopharyngeal carcinoma exposed to radiotherapy and adjuvant chemotherapy identi ed the presence of severe tooth wear in 92.6% of participants. In this study, the presence of hyposalivation was associated with tooth wear, reinforcing the role of saliva in preserving the integrity of mineralized dental tissues [24]. From a clinical point of view, the surface roughness is of total importance, having a direct relationship in the adhesion of bacteria, increasing the accumulation of bio lm and consequently causing irreversible damage to dental hard tissues.…”

Section: Discussionsupporting

confidence: 53%

Abrasive challenge effects on enamel and dentin from irradiated human teeth: an in vitrostudy

Arid

Palma‐Dibb

Oliveira

et al. 2023

Preprint

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Background: The objective of this study was to evaluate wear and surface roughness of in vivo irradiated human enamel and dentin after abrasive challenge. Methods: Using teeth donated by healthy patients or with head and neck cancer who received radiotherapy (RT) or chemoradiotherapy (CRT), 42 enamel and dentin specimens were made, divided into three groups: control, RT and CRT (n = 14 in each group, both for enamel and dentin). The specimens were submitted to an in vitroexperimental abrasive using a brushing machine and wear and surface roughness were evaluated. Results: In enamel specimens, wear profile values of CRT and RT groups were not different from control (p-value >0.05). The RT group presents lower step values than CRT and control groups (p-value <0.001). No significant difference in final surface roughness was observed in all groups (p-value >0.05). In dentin specimens, no significant difference in wear profile and step was observed in all groups (p-value >0.05). However, CRT and RT groups present higher values in final surface roughness (p-value <0.001). Conclusion: The exposure to ionizing radiation (associated or not to chemotherapy) influenced the surface roughness of dentin and the wear (step) of enamel after the in vitro abrasive challenge. Trial registration: Ethical procedures were approved by the FORP/USP Research Ethics Committee (CAAE: 61308416.4.0000.5419) and Hospital do Câncer de Barretos/Fundação Pio XII (CAAE: 61308416.4.3001.5437). Clinical relevance: Considering probable effects of ionizing radiation on teeth structure, understanding the behaviour of enamel and dentin under physiological processes is important to prevent and treat adverse oral side effects related to radiotherapy.

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Section: Discussionsupporting

confidence: 53%

Abrasive challenge effects on enamel and dentin from irradiated human teeth: an in vitrostudy

Arid

Palma‐Dibb

Oliveira

et al. 2023

Preprint

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“…However, the traumatic strategy increases the risk of secondary infection [11]. Furthermore, teeth of people in highcarbonhydrate diet and the patients suffered from temporomandibular disorders, excessive occlusal forces, and tooth wear are also susceptible to these infectious oral diseases [12,13]. Hence, it is urgent to explore a daily, nondestructive, and low-cost strategy to enhance the dental collagen stability.…”

Section: Introductionmentioning

confidence: 99%

From medical strategy to food-borne prophylactic strategy: stabilizing dental collagen with aloin

jia

Yang

et al. 2023

Preprint

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Objectives: We developed a food-borne prophylactic strategy with aloin to protect dental collagen through enhancing the mechanical strength, thermostability, and the resistance to enzymatic hydrolysis of dental collagen. The mechanism and effect of this food-borne prophylactic strategy were examined. Methods: Aloin solution (0.1 mg/mL) was prepared. The concentration is equivalent to the natural content of aloin in edible aloe. Attenuated total reflectance flourier transform infrared spectroscopy (ATR-FTIR), Gaussian peak fitting, and X-ray diffraction (XRD) were used to explore the mechanism of interaction between aloin and dental collagen in situ. Mechanical strength and thermostability were separately evaluated via Ultimate tensile strength test (UTS) and thermogravimetric analysis (TGA). Hydroxyproline (HYP), cross-linked carboxy-terminal telopeptide of type I collagen (ICTP), and C-terminal crosslinked telopeptide of type I collagen (CTX) were used as indicators to evaluate the resistance to enzymatic hydrolysis. Wight loss was further tested as macro-parameter to evaluate the effectiveness of aloin on dental collagen stability. Results: Aloin can interact with dental collagen via hydrogen bonds in humid environment. The interaction shorted the intermolecular distance and enhanced the proportion of stable α-helix chain of dental collagen. Aloin-treated dental collagen exhibited improved mechanical strength, thermostability and enzymatic stability. Conclusion: Aloin can strongly integrate with dental collagen under physiological conditions via hydrogen bonds and significantly enhance the dental collagen stability. Clinical Relevance: The use of aloin maybe a daily, nondestructive, and low-cost strategy to protect dental collagen.

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“…Third, conventional strategies are typically reserved for patients who have already experienced tooth tissue infections or dental defects. For individuals at high risk but currently without any infection, such as those on a high‐carbohydrate diet or patients with temporomandibular disorders, excessive occlusal forces, or tooth wear, this method can lead to more extensive damage and an increased risk of secondary infection (Lam et al., 2020 ; Murtaza et al., 2019 ). Furthermore, all the strategies mentioned above must be executed by professional dentists and cannot be applied universally by the general population.…”

Section: Introductionmentioning

confidence: 99%

From medical strategy to foodborne prophylactic strategy: Stabilizing dental collagen with aloin

Jia,

Li,

Yang

et al. 2023

Food Science & Nutrition

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Infectious oral diseases are longstanding global public health concerns. However, traditional medical approaches to address these diseases are costly, traumatic, and prone to relapse. Here, we propose a foodborne prophylactic strategy using aloin to safeguard dental collagen. The effect of aloin on the stability of dental collagen was evaluated by treating dentin with a solution containing aloin (0.1 mg/mL) for 2 min. This concentration is comparable to the natural aloin content of edible aloe. Furthermore, we investigated the mechanisms underlying the interactions between aloin and dentin collagen. Our findings, obtained through fluorescence spectroscopy, attenuated total reflection Fourier transform infrared spectroscopy, Gaussian peak fitting, circular dichroism spectroscopy, and X‐ray diffraction, revealed that aloin interacts with dental collagen through noncovalent bonding, specifically hydrogen bonding in situ. This interaction leads to a reduction in the distance between molecules and an increase in the proportion of stable α‐helical chains in the dental collagen. The ultimate tensile strength and thermogravimetric analysis demonstrated that dental collagen treated with aloin exhibited improved mechanical strength and thermostability. Additionally, the release of hydroxyproline, cross‐linked carboxy‐terminal telopeptide of type I collagen, and C‐terminal cross‐linked telopeptide of type I collagen, along with weight loss, indicated an enhancement in the enzymatic stability of dental collagen. These findings suggest that aloin administration could be a daily, nondestructive, and cost‐effective strategy for managing infectious oral diseases.

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Impact of hypo-salivation on severe tooth wear: A ten-year cohort of patients received radiotherapy for nasopharyngeal carcinoma

Cited by 7 publications

References 46 publications

Abrasive challenge effects on enamel and dentin from irradiated human teeth: an in vitrostudy

Abrasive challenge effects on enamel and dentin from irradiated human teeth: an in vitrostudy

From medical strategy to food-borne prophylactic strategy: stabilizing dental collagen with aloin

From medical strategy to foodborne prophylactic strategy: Stabilizing dental collagen with aloin

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