Impact of
            <i>ABCB1</i>
            C3435T Polymorphism on Lymph node Regression in Multimodality Treatment of Locally Advanced Esophageal Cancer

Narumiya, Kosuke; Metzger, Ralf; Bollschweiler, Elfriede; Alakus, Hakan; Brabender, Jan; Drebber, Uta; Hölscher, Arnulf H.; Warnecke-Eberz, Ute

doi:10.2217/pgs.10.174

Cited by 19 publications

(16 citation statements)

References 30 publications

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“…SNPs in ABC transporters can significantly change the activity. Narumiya et al have reported that SNP rs1045642 in ABCB1 (alias Pgp or MDR1, 171050) gene may affect the patient response to neoadjuvant chemoradiation, and, more specifically, the response of lymph node invaded by tumor cells [ 14 ].…”

Section: Search Results and Discussionmentioning

confidence: 99%

“…The rs2032582 SNP has recently been studied as a part of panel of five SNPs (single SNPs in genes ABCB1 , 5,10-Methylenetetrahydrofolate reductase ( MTHFR , 607093), Glutathione S -transferase, pi ( GSTP1 , 134660), and two SNPs in Xeroderma pigmentosum, complementation group C ( XPC , 613208) modifying progression-free survival of 124 locally advanced EC (62 with ESCC and 62 with EAC) patients who received neoadjuvant chemoradiation based on cisplatin, docetaxel, and 5-fluorouracil [ 18 ]. Although Okuno et al found no association of rs1045642 SNP with response rate or survival of ESCC patients [ 19 ], Narumiya et al have analyzed impact of ABCB1 rs1045642 SNP on outcome of EC patients (116 with ESCC and 146 with EAC) after neoadjuvant treatment with cisplatin- and 5-fluorouracil-based chemoradiation and observed that CC genotype was associated with lymph node and distant metastases and predicted shorter overall survival [ 14 ]. These differences could be due to different frequency of rs1045642 SNP in studied populations, Caucasian (Narumiya et al) [ 14 ] versus Japanese (Okuno et al) [ 19 ].…”

Section: Search Results and Discussionmentioning

confidence: 99%

“…Although Okuno et al found no association of rs1045642 SNP with response rate or survival of ESCC patients [ 19 ], Narumiya et al have analyzed impact of ABCB1 rs1045642 SNP on outcome of EC patients (116 with ESCC and 146 with EAC) after neoadjuvant treatment with cisplatin- and 5-fluorouracil-based chemoradiation and observed that CC genotype was associated with lymph node and distant metastases and predicted shorter overall survival [ 14 ]. These differences could be due to different frequency of rs1045642 SNP in studied populations, Caucasian (Narumiya et al) [ 14 ] versus Japanese (Okuno et al) [ 19 ]. Additionally, the analysis of 116 ESCC patients in the former study demonstrated no significant role for ABCB1 genotype in terms of survival of patients, pointing to a possible difference between histological types of EC [ 14 ].…”

Section: Search Results and Discussionmentioning

confidence: 99%

“…These differences could be due to different frequency of rs1045642 SNP in studied populations, Caucasian (Narumiya et al) [ 14 ] versus Japanese (Okuno et al) [ 19 ]. Additionally, the analysis of 116 ESCC patients in the former study demonstrated no significant role for ABCB1 genotype in terms of survival of patients, pointing to a possible difference between histological types of EC [ 14 ]. Interestingly, ABCB1 rs1045642 SNP did not associate with lansoprazole plasma concentrations in 51 Japanese patients with EC of unspecified histology.…”

Section: Search Results and Discussionmentioning

confidence: 99%

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ABC Transporters and Their Role in the Neoadjuvant Treatment of Esophageal Cancer

Vrána

Hlaváč

Brynychová

et al. 2018

IJMS

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The prognosis of esophageal cancer (EC) is poor, despite considerable effort of both experimental scientists and clinicians. The tri-modality treatment consisting of neoadjuvant chemoradiation followed by surgery has remained the gold standard over decades, unfortunately, without significant progress in recent years. Suitable prognostic factors indicating which patients will benefit from this tri-modality treatment are missing. Some patients rapidly progress on the neoadjuvant chemoradiotherapy, which is thus useless and sometimes even harmful. At the same time, other patients achieve complete remission on neoadjuvant chemoradiotherapy and subsequent surgery may increase their risk of morbidity and mortality. The prognosis of patients ranges from excellent to extremely poor. Considering these differences, the role of drug metabolizing enzymes and transporters, among other factors, in the EC response to chemotherapy may be more important compared, for example, with pancreatic cancer where all patients progress on chemotherapy regardless of the treatment or disease stage. This review surveys published literature describing the potential role of ATP-binding cassette transporters, the genetic polymorphisms, epigenetic regulations, and phenotypic changes in the prognosis and therapy of EC. The review provides knowledge base for further research of potential predictive biomarkers that will allow the stratification of patients into defined groups for optimal therapeutic outcome.

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Section: Search Results and Discussionmentioning

confidence: 99%

Section: Search Results and Discussionmentioning

confidence: 99%

Section: Search Results and Discussionmentioning

confidence: 99%

Section: Search Results and Discussionmentioning

confidence: 99%

See 2 more Smart Citations

ABC Transporters and Their Role in the Neoadjuvant Treatment of Esophageal Cancer

Vrána

Hlaváč

Brynychová

et al. 2018

IJMS

View full text Add to dashboard Cite

show abstract

“…It has been found that the increased risk of ESCC relates to combined SULT1A12*2 genotype and CYP3A5 heterozygous genotypes, especially in tobacco smokers (Dandara et al, 2006). SNP of ATP-binding cassette sub-family B (MDR/TAP) member 1 gene (ABCB1) was reported to be associated with lymph node and distant metastases in EC (Narumiya et al, 2011). SNP also impacted disease-free survival (DFS) of ECs.…”

Section: Effects Of Mutations and Snps In Esophageal Cancermentioning

confidence: 99%

Molecular Biology Character of Esophageal Cancer

Guo¹,

Jia²,

Wu³

2012

Esophageal Cancer - Cell and Molecular Biology, Biomarkers, Nutrition and Treatment

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Impact of ABCB1, ABCC1, ABCC2, and ABCG2 variants in predicting prognosis and clinical outcomes of north Indian lung cancer patients undergoing platinum‐based doublet chemotherapy

Sharma

Singh

Sharma

2022

The Journal of Gene Medicine

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Background ABC transporters are membrane proteins expressed in the lungs and are crucial for efflux of various chemotherapeutic agents. Polymorphisms of ABC transporters have a certain impact on the transporter activity because their expression levels may influence the extent and longevity of chemotherapeutic drug outflow, affecting patient outcomes. The present study aimed to assess the impact of ABCB1, ABCC1/2, and ABCG2 gene variants in predicting prognosis and clinical outcomes in lung carcinoma patients. Methods In total, 502 lung cancer patients undergoing platinum‐based chemotherapy were recruited in this prospective study. Genotyping of ABCB1 (C1236T, C3435T, and G2677T/A), ABCC1 (G3173A and G2168A), ABCC2 (G4544A), and ABCG2 (C421A) polymorphisms in Northern Indian lung carcinoma patients were evaluated using polymerase chain reaction‐restriction fragment length polymorphism analysis. Results Poor survival outcomes were noted in patients carrying a heterozygous genotype (CT) for the ABCB1 C1236T polymorphism compared to the wild‐type genotype (CC) (p = 0.04). The mutant genotype (AA) for ABCC1 G3173A exhibited a lower median survival time compared to the reference genotype (GG) (p = 0.009). Lower survival was observed in individuals carrying a heterozygous genotype (GA) for ABCC2 G4544A polymorphism compared to the wild‐type genotype (GG) (p = 0.017). Small cell lung cancer patients with the ABCB1 G2677A polymorphism having a heterozygous genotype (GA) showed poor survival compared to the wild‐type genotype (GG) (p = 0.03). For ABCC1 G3173A, adenocarcinoma patients having a mutant genotype (AA) had reduced survival compared to the wild‐type (GG) genotype (p = 0.03). For ABCB1 C3435T, individuals carrying a heterozygous (CT) (p = 0.018) and mutant (TT) genotype (p = 0.007) had poor survival compared to the wild‐type (CC) genotype in patients treated with pemetrexed and cisplatin. The patients administered cisplatin and irinotecan and having mutant alleles (AA) for the ABCB1 G2677A polymorphism showed a lower survival compared to the individuals carrying wild‐type alleles (GG) (p = 0.009). Conclusions Our findings suggest that ABCB1 C1236T, ABCB1 C3435T, ABCB1 G2677A, ABCC1 G3173A, and ABCC2 G4544A are involved in predicting prognosis. Genotyping of the ABC polymorphism is essential for predicting prognosis in lung carcinoma patients.

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Impact of ABCB1 C3435T Polymorphism on Lymph node Regression in Multimodality Treatment of Locally Advanced Esophageal Cancer

Abstract: Our data supports the impact of ABCB1 on effectiveness of esophageal cancer treatment. SNPs of ABCB1 could be helpful in predicting lymph node regression in the multimodality treatment of locally advanced esophageal cancer.

Cited by 19 publications

References 30 publications

ABC Transporters and Their Role in the Neoadjuvant Treatment of Esophageal Cancer

ABC Transporters and Their Role in the Neoadjuvant Treatment of Esophageal Cancer

Molecular Biology Character of Esophageal Cancer

Impact of ABCB1, ABCC1, ABCC2, and ABCG2 variants in predicting prognosis and clinical outcomes of north Indian lung cancer patients undergoing platinum‐based doublet chemotherapy

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