Impact of
            <i>CYP2C8</i>
            and
            <i>2C9</i>
            Polymorphisms on Coronary Artery Disease and Myocardial Infarction in the LURIC Cohort

Haschke-Becher, Elisabeth; Kirchheiner, Julia; Trummer, Olivia; Grünbacher, Gerda; Kainz, Alexander; Boehm, Bernhard O.; März, Winfried; Renner, Wilfried

doi:10.2217/pgs.10.96

Cited by 16 publications

(14 citation statements)

References 44 publications

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“…The lack of association between CYP2C9 and risk of ischemic vascular disease in this study is in accordance with other studies [79][80][81][82]. A few studies have detected an association for different subpopulations, but these findings are solitary and in the opposite direction, and have not been replicated [80,[83][84][85][86].…”

Section: Cyp2c9 and Risk Of Ischemic Vascular Diseasesupporting

confidence: 85%

“…However, the finding could not be confirmed in a large prospective study or in a large case-control study with enough power to exclude even minor changes of risk with 90% power [78]. The lack of association between CYP2C9 and risk of ischemic vascular disease in this study is in accordance with other studies [79][80][81][82]. A few studies have detected an association for different subpopulations, but these findings are solitary and in the opposite direction, and have not been replicated [80,[83][84][85][86].…”

Section: Cyp2c9 and Risk Of Ischemic Vascular Diseasecontrasting

confidence: 46%

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Cytochrome P450 1B1 and 2C9 Genotypes and Risk of Ischemic Vascular Disease, Cancer, and Chronic Obstructive Pulmonary Disease

Kaur-Knudsen

Bojesen²,

Nordestgaard³

2012

CVP

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The aim of this review is to summarize present knowledge of genetic variation in cytochrome P450 1B1 (CYP1B1) and 2C9 (CYP2C9) genes and risk of tobacco-related cancer, female cancer, chronic obstructive pulmonary disease and ischemic vascular disease. The CYP1B1 and CYP2C9 enzymes metabolize polycyclic aromatic hydrocarbons found in tobacco smoke and thereby generate disease-causing metabolites suggested to be important in tobacco-related diseases. Furthermore, CYP1B1 also metabolizes estrogen while CYP2C9 metabolizes arachidonic acid, both creating metabolites potentially important in risk of female cancer or ischemic vascular disease. Genetic variation in genes coding for CYP1B1 and CYP2C9 enzymes have shown altered enzyme activity affecting levels of metabolites and thus potentially risk of disease. So far, however, findings have been inconsistent. Recently, large studies on the association between genetic variation in CYP1B1 and CYP2C9 and risk of disease with considerable statistical power rebutted the hypotheses that these genetic variants affect risk of tobacco-related cancer, female cancer, chronic obstructive pulmonary disease and ischemic vascular disease.

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Section: Cyp2c9 and Risk Of Ischemic Vascular Diseasesupporting

confidence: 85%

Section: Cyp2c9 and Risk Of Ischemic Vascular Diseasecontrasting

confidence: 46%

Cytochrome P450 1B1 and 2C9 Genotypes and Risk of Ischemic Vascular Disease, Cancer, and Chronic Obstructive Pulmonary Disease

Kaur-Knudsen

Bojesen²,

Nordestgaard³

2012

CVP

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show abstract

“…In subjects enrolled in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study, no significant differences in coronary artery disease between individuals carrying different CYP2C8 and 2C9 genotypes. When the population carrying the CYP2C9*3 allele was split according to sex, increased risk of MI was found in men and decreased risk in women [59]. The use of CYP2C9 substrates and inhibitors was associated with a significant increase in the risk of myocardial infarction especially in female harbouring a variant allele (CYP2C8*2, CYP2C9*3) [60].…”

Section: Cyp2c8 Cyp2c9 Hypertension and Cardiovascular Diseasesmentioning

confidence: 99%

Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?

Fava

Ricci

Melander

et al. 2012

Prostaglandins & Other Lipid Mediators

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“…Some evidence has indicated that the levels of sex hormones could affect the development of cardiovascular and cerebrovascular diseases [20]. Sex hormones including estrogens protect against oxidative stress and are known to be vaso protective [21][22][23].…”

mentioning

confidence: 99%

Relationship between CYP17A1 Genetic Polymorphism and Essential Hypertension in a Chinese Population

Dai¹,

Xie²,

Ma³

et al. 2015

aging dis

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ABSTRACT:The relationship between CYP17A1 genetic polymorphisms and essential hypertension (EH) remains unclear. The aim of this study was to investigate the association of CYP17A1 genetic polymorphisms with EH in Han and Uighur populations in China. A Han population including 558 people (270 EH patients and 288 controls) and a Uighur population including 473 people (181 EH patients and 292 controls) were selected. Five single-nucleotide polymorphisms (SNPs) (rs4919686, rs1004467, rs4919687, rs10786712, and rs2486758) were genotyped using real-time PCR (TaqMan). In the Uighur population, for the total and the men, rs4919686, rs4919687 and rs10786712 were found to be associated with EH (rs4919686: P≤0.02, rs4919687: P≤0.002, rs10786712: P≤0.004, respectively). The difference remained statistically significant after the multivariate adjustment (all P<0.05). The overall distributions of the haplotypes established by SNP1-SNP3, SNP1-SNP4, SNP1-SNP3-SNP5 and SNP1-SNP4-SNP5 were significantly different between the EH patients and the control subjects (for the total: P=0.013, P=0.008, P=0.032, P=0.010, for men: P<0.001, P=0.001, P=0.010, P=0.00). In the Han population, for men, rs2486758 was found to be associated with EH in a recessive model (P=0.007); the significant difference was not retained after the adjustment for the covariates (date not shown). The A allele of rs4919686 could be a susceptible genetic marker, and the T allele of rs10786712 could be a protective genetic marker of EH. The AC genotype of rs4919686, the AG genotype of rs4919687 and the TT genotype of rs10786712 could be protective genetic markers of EH.

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Impact of CYP2C8 and 2C9 Polymorphisms on Coronary Artery Disease and Myocardial Infarction in the LURIC Cohort

Abstract: Overall, LURIC data confirmed that there is no major cardiovascular risk associated with CYP2C8 and CYP2C9 variants in a cardiovascular risk population of patients having undergone coronary angiography.

Cited by 16 publications

References 44 publications

Cytochrome P450 1B1 and 2C9 Genotypes and Risk of Ischemic Vascular Disease, Cancer, and Chronic Obstructive Pulmonary Disease

Cytochrome P450 1B1 and 2C9 Genotypes and Risk of Ischemic Vascular Disease, Cancer, and Chronic Obstructive Pulmonary Disease

Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?

Relationship between CYP17A1 Genetic Polymorphism and Essential Hypertension in a Chinese Population

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