Impact of
 CYP2C9
 ,
 VKORC1
 ,
 ApoE
 and
 ABCB1
 Polymorphisms on Stable Warfarin Dose Requirements in Elderly Chinese Patients

Li, Wenyan; Zhao, Ping; Chen, Liwen; Lai, Xiaoyin; Shi, Guohua; Dong, Jing

doi:10.2217/pgs-2019-0139

Cited by 9 publications

(20 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A schematic of the literature screening process is shown in Figure 1. A total of 124 articles were screened, and four articles describing 757 patients were included in the meta-analysis [9,25,30,31]. All included studies were published in English between 2007 2Cardiovascular Therapeutics and 2020.…”

Section: Study Identification and Characteristicsmentioning

confidence: 99%

“…Only one article referred to African-Americans [25]. The other included studies referred to Asian populations [9,30,31]. Moreover, only two studies focused on the relationship between NQO1 rs10517 genotypes and MDWDs [9,30].…”

Section: Study Identification and Characteristicsmentioning

confidence: 99%

“…The other included studies referred to Asian populations [9,30,31]. Moreover, only two studies focused on the relationship between NQO1 rs10517 genotypes and MDWDs [9,30]. According to the Newcastle-Ottawa Scale checklist, all studies with scores of 7 stars were considered as high quality.…”

Section: Study Identification and Characteristicsmentioning

confidence: 99%

“…Maintenance Dosage. There were four articles [9,25,30,31] included in this meta-analysis, and the results are shown in Figure 2. Compared with the NQO1 rs1800566 homozygous genotype (CC carriers), the warfarin dose in patients with the CT genotype was 13% higher (P value = 0.01, 95% confidence interval (CI) 0.03-0.22).…”

Section: Relationship Between Nqo1 Rs1800566 and Warfarinmentioning

confidence: 99%

“…Maintenance Dosage. Only two studies [9,30] were included in this meta-analysis, which included 420 patients. Because of the limited number of patients with each genotype, we only conducted comparisons between NQO1 rs10517 G carriers and AA carriers.…”

Section: Relationship Between Nqo1 Rs10517 and Warfarinmentioning

confidence: 99%

See 4 more Smart Citations

Influence of NQO1 Polymorphisms on Warfarin Maintenance Dose: A Systematic Review and Meta-Analysis (rs1800566 and rs10517)

Tian¹,

Xiao²,

Zhou³

et al. 2021

Cardiovascular Therapeutics

View full text Add to dashboard Cite

This meta-analysis was conducted to analyze the effect of NQO1 polymorphism on the warfarin maintenance dosage. Using strict inclusion and exclusion criteria, we searched PubMed, EMBASE, and the Cochrane Library for eligible studies published prior to July 7, 2021. The required data were extracted, and experts were consulted when necessary. Review Manager Version 5.4 software was used to analyze the relationship between NQO1 polymorphisms and the warfarin maintenance dosage. Four articles involving 757 patients were included in the meta-analysis. Patients who were NQO1 rs10517 G carriers (AG carriers or GG carriers) required a 48% higher warfarin maintenance dose than those who were AA carriers. Patients with NQO1 rs1800566 CT carriers required a 13% higher warfarin dose than those who were CC carriers, with no associations observed with the other comparisons of the NQO1 rs1800566 genotypes. However, the results obtained by comparing the NQO1 rs1800566 genotypes require confirmation, as significant changes in the results were found in sensitivity analyses. Our meta-analysis suggests that the NQO1 rs10517and NQO1 rs1800566 variant statuses affect the required warfarin maintenance dose.

show abstract

Section: Study Identification and Characteristicsmentioning

confidence: 99%