Impact of<i>IL-28B</i>polymorphism on outcome in patients with hepatitis C after liver transplantation

Neumann, Ulf

doi:10.1586/egh.11.54

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Among the 60 initially identified studies with potential relevance, 24 were excluded based on the study population having: spontaneous clearance of HCV ( n = 6); HIV co‐infection ( n = 6); liver transplant ( n = 6); decompensated liver cirrhosis or HCC ( n = 3); treatment with non‐PEG IFN ( n = 1); and no SVR data for IL28B rs12979860 or rs8099917 polymorphisms ( n = 2). In addition, 11 articles were excluded for being: reviews ( n = 10); and an earlier publication of a multi‐published trial ( n = 1).…”

Section: Resultsmentioning

confidence: 99%

Meta‐analysis: IL28B polymorphisms predict sustained viral response in HCV patients treated with pegylated interferon‐α and ribavirin

Chen

Wang

et al. 2012

Aliment Pharmacol Ther

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Section: Resultsmentioning

confidence: 99%

Meta‐analysis: IL28B polymorphisms predict sustained viral response in HCV patients treated with pegylated interferon‐α and ribavirin

Chen

Wang

et al. 2012

Aliment Pharmacol Ther

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Correlation between IL-28 polymorphism and spontaneous clearance in HCV patients: systematic review and meta-analysis

et al. 2021

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Hepatitis C virus (HCV) is a serious global health issue. Nearly 20% of HCV patients spontaneous clear the virus. While some studies have shown the association of spontaneous clearance (SC) of the virus with Interleukin (IL) 28B single nucleotide polymorphisms (SNPs), others didn't show such a relationship. Thus, the purpose of the present study was to investigate the association of IL28B polymorphisms (12979860 SNP) and SC of HCV infection. Upon initial screening of the databases, a total of 545 articles were retrieved, of which 22 studies that met prede ned eligibility criteria were entered into the meta-analysis.Odds ratios (OR) with its con dence intervals (95% CI), heterogeneity, publication bias, and sensitivity analysis were assessed. According to the meta-analysis results, a signi cant association was observed between the rs12979860 SNP and SC of HCV infection. The results indicated that the ORs of SC from hepatitis C virus infection were 2.75 times higher in those with cytokine gene polymorphisms, 95% CI (2.23 to 3.38). Moreover, it was found that the prevalence of rs12979860 CC was 0.33 with 95 CI (0.28-0.38) in genotype one and was 0.40 with 95 CI (0.34-0.47) in other genotypes.Our meta-analysis results suggest that IL28B rs12979860 CC is a strong predictor for SC of hepatitis C infection in PEG IFN-a/RBV-treated patients.

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Genetic Variations in Host Factors and their Critical Role on HCV Medication

et al. 2017

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Although standard treatments are nearly life-saving in hepatitis C patients, all patients equalldon't respond to such medications. To achieve an efficient therapeutic response in all patients, medications should individually alter based on genetic factor variations. Hence, having more detailed knowledge of the affective factors on the disease promotion could help us to organize an appropriate regime to treat HCV patients. In order to review recent studies on HCV-related treatments, the data was collected from the clinical and molecular studies published during the last 15 years in electronic databases such as PubMed, Google Scholar, Medline, Scopus and Web of Sciences. Thus, this literature reviews the recent clinical studies with the genetic-based aspects, especially those factors affecting the etiopathological and histological feature of hepatitis C, diagnostic genetic and viral affecting criteria as well as some effective treatment strategies.

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Impact ofIL-28Bpolymorphism on outcome in patients with hepatitis C after liver transplantation

Cited by 3 publications

References 15 publications

Meta‐analysis: IL28B polymorphisms predict sustained viral response in HCV patients treated with pegylated interferon‐α and ribavirin

Meta‐analysis: IL28B polymorphisms predict sustained viral response in HCV patients treated with pegylated interferon‐α and ribavirin

Correlation between IL-28 polymorphism and spontaneous clearance in HCV patients: systematic review and meta-analysis

Genetic Variations in Host Factors and their Critical Role on HCV Medication

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