Impact of IgD Receptor-Positive T Cells on the Immune Response

Role of IgD and Tδ Cells in the Regulation of the Humoral Immune Response

“…IgD receptor expression following treatment with IgD (Coico et al 1987a(Coico et al , 1988a. Table II also demonstrates that the cell populations comprising cells with increased IgD receptor expression transferred the ability to produce increased antibody responses to normal recipients.…”

“…It was therefore of interest to determine whether IgD receptors could be influenced by Iymphokines. The results in Table VI show that IL-2, IL-4 and IFNy, but not IL-1 or tumor necrosis factor-alpha (TNFa) upregulate IgD receptors on splenic T cells during overnight incubation in vitro (Coico et al 1987a(Coico et al , 1988a. In addition, IL-2 and IFNy were found to induce Td cells in vivo (Table V) (Coico et al 1987a).…”

Release of IgD-binding factor by T cells under the influence of interleukin 2, interleukin 4, or cross-linked IgD.

“…Demonstration of IgD-BF Released from T Cells Incubated with rIL-2. In previous experiments rIL-2 was found to induce functional IgD receptors on T cells (16); release of IgD-BF by such cells was therefore studied (Fig. 2).…”

“…Crosslinking of soluble IgD or of B-cell surface IgD is required for upregulating receptors for IgD on T cells both in vivo and in vitro (15). Receptors for IgD are also induced on T helper cells by lymphokines such as interleukin 2 (IL-2), interleukin 4 (IL-4) (16), and interferon y (17,18). Similarly, antigen-specific cloned T cells show an increased incidence of IgD rosette-forming cells (RFC) after incubation with IgD, antigen, or recombinant IL-2 (rIL-2) (17).…”