2021
DOI: 10.1101/2021.10.14.464395
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Impact of IgG isotype on the induction of antibody-dependent cellular phagocytosis of HIV by human milk leukocytes

Abstract: Approximately 100,000 mother-to-child transmission (MTCT) events of HIV via human milk feeding occur each year (1). However, only about 15% of infants milk-fed by untreated HIV+ mothers become infected, suggesting a protective effect of the milk itself (1, 2). Infants ingest 105-108 maternal leukocytes daily via milk, which remain functional beyond ingestion (3-9). Such function may be elicited by maternal milk antibody (Ab). Though IgA is dominant in milk, most HIV-specific milk Abs are of the IgG subclass, h… Show more

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