Impact of IL-17F 7488T/C Functional Polymorphism on Progressive Rheumatoid Arthritis: Novel Insight from the Molecular Dynamic Simulations

Nisar, Haseeb; Pasha, U. Mahaboob; Mirza, Muhammad Usman; Abid, Rizwan; Hanif, Kiran; Kadarmideen, Haja N.; Sadaf, Saima

doi:10.1080/08820139.2020.1775642

Cited by 13 publications

(5 citation statements)

References 36 publications

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“…Residues are considered pivotal in the complex if they bound the ligand with an interaction energy of less than −1 kcal mol −1 . [ 25 ] The interaction energies of HASPy and residues at the active site of IL‐17A were calculated and are listed in Tables S3 and S6 (Supporting Information), respectively. Six key residues were VAL90, ILE92, LEU116, VAL119, VAL124, and H_ILE51 in the IL‐17(A, RAH)/HASPy complex and their interaction energy levels were −2.19, −2.75, −5.91, −1.05, −1.18, and −1.28 kcal mol −1 , respectively.…”

Section: Resultsmentioning

confidence: 99%

A Bioinspired Self‐Healing Conductive Hydrogel Promoting Peripheral Nerve Regeneration

Xuan,

Wu,

Jin

et al. 2023

Advanced Science

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The development of self‐healing conductive hydrogels is critical in electroactive nerve tissue engineering. Typical conductive materials such as polypyrrole (PPy) are commonly used to fabricate artificial nerve conduits. Moreover, the field of tissue engineering has advanced toward the use of products such as hyaluronic acid (HA) hydrogels. Although HA‐modified PPy films are prepared for various biological applications, the cell–matrix interaction mechanisms remain poorly understood; furthermore, there are no reports on HA‐modified PPy‐injectable self‐healing hydrogels for peripheral nerve repair. Therefore, in this study, a self‐healing electroconductive hydrogel (HASPy) from HA, cystamine (Cys), and pyrrole‐1‐propionic acid (Py‐COOH), with injectability, biodegradability, biocompatibility, and nerve‐regenerative capacity is constructed. The hydrogel directly targets interleukin 17 receptor A (IL‐17RA) and promotes the expression of genes and proteins relevant to Schwann cell myelination mainly by activating the interleukin 17 (IL‐17) signaling pathway. The hydrogel is injected directly into the rat sciatic nerve‐crush injury sites to investigate its capacity for nerve regeneration in vivo and is found to promote functional recovery and remyelination. This study may help in understanding the mechanism of cell–matrix interactions and provide new insights into the potential use of HASPy hydrogel as an advanced scaffold for neural regeneration.

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Section: Resultsmentioning

confidence: 99%

A Bioinspired Self‐Healing Conductive Hydrogel Promoting Peripheral Nerve Regeneration

Xuan,

Wu,

Jin

et al. 2023

Advanced Science

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“…[38] Some studies have reported that IL17 rs763780 C allele was significantly related to RA risk in Caucasians, [23] Mongolians, [36] Brazilians [39] and Pakistanis. [40] And H.F. Pasha, et al also found that there was significant IL17A rs2275913 genes polymorphisms with their serum levels, susceptibility, disease activity and severity in Egyptian SLE patients. [28]…”

Section: Discussionmentioning

confidence: 99%

IL12B and IL17 genes polymorphisms associated with differential susceptibility to juvenile idiopathic arthritis and juvenile-onset systemic lupus erythematosus in Chinese children

Zhang

Peng

et al. 2023

Medicine

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Genetic factors play a crucial role in the immune response of juvenile idiopathic arthritis (JIA) and juvenile-onset systemic lupus erythematosus (JSLE). This study aimed to investigate the association of IL12B (rs3212227, rs6887695) and IL17 (rs2275913, rs763780) gene polymorphisms with the susceptibility of JIA and JSLE in Chinese children. A total of 303 healthy controls and 304 patients including 160 JIA and 144 patients were analyzed, and the genetic polymorphisms were genotyped by using a Sequenom MassArray system. There was a significant association between the IL12B rs3212227 genotype and the increased risk of JSLE (P = .01). For rs6887695, the minor allele C was significantly associated with the increased risk of JIA (odds ratio = 1.48, 95% confidence interval [CI] = 1.12–1.95, P = .005). Moreover, rs6887695 genotype was significantly associated with both JIA and JSLE susceptibility (P < .05). Besides, IL12B haplotype GC significantly associated with the increased risk of JIA (P = .016). However, no significant difference was found between the IL17 (rs2275913, rs763780) gene polymorphisms and JIA or JSLE susceptibility (P > .05). And similar genotype distributions of IL12B and IL17 polymorphisms were found between the patients with nephritis and without nephritis in JSLE (P > .05). Our results indicated that IL12B polymorphisms was associated with an increased risk for the development of JIA and JSLE in Chinese children, highlighting the involvement of inflammation in the pathogenesis of JIA and JSLE. Moreover, there was a risk haplotype in IL12B which could increase the risk of JIA.

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“…Although the mechanism by which the minor allele of IL17A rs2275913 and IL17F rs763780 contribute to autoimmune diseases is not well understood, it is thought to in uence the IL-17mRNA and modify the protein's amino acid sequence, converting the histidine (CAT) to arginine (CGT) [38]. Some studies have reported that IL17 rs763780 C allele was signi cantly related to RA risk in Caucasians [23], Mongolians [36], Brazilians [39] and Pakistanis [40]. And H.F. Pasha, et al also found that there was signi cant IL17A rs2275913 genes polymorphisms with their serum levels, susceptibility, disease activity and severity in Egyptian SLE patients [28].…”

Section: Discussionmentioning

confidence: 99%

IL12B and IL17 genes polymorphisms are associated with different susceptibility to Juvenile Idiopathic Arthritis and Juvenile-onset Systemic Lupus Erythematosus in Chinese children

Zhang

Peng

et al. 2023

Preprint

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Background Genetic factors play a crucial role in the immune response of juvenile idiopathic arthritis (JIA) and juvenile-onset systemic lupus erythematosus (JSLE). This study aimed to investigate the association of IL12B (rs3212227, rs6887695) and IL17 (rs2275913, rs763780) gene polymorphisms with the susceptibility of JIA and JSLE in Chinese children. Methods A total of 303 healthy controls and 304 patients including 160 JIA and 144 patients were analyzed, and the genetic polymorphisms were genotyped by using a Sequenom MassArray system. Results There was a significant association between the IL12B rs3212227 genotype and the increased risk of JSLE (p = 0.01). For rs6887695, the minor allele C was significantly associated with the increased risk of JIA (odds ratio = 1.48, 95% CI = 1.12–1.95, p = 0.005). Moreover, rs6887695 genotype was significantly associated with both JIA and JSLE susceptibility (p < 0.05). Besides, IL12B haplotype GC significantly associated with the increased risk of JIA (p = 0.016). However, no significant difference was found between the IL17 (rs2275913, rs763780) gene polymorphisms and JIA or JSLE susceptibility (p > 0.05). And similar genotype distributions of IL12B and IL17 polymorphisms were found between the patients with nephritis and without nephritis in JSLE (p > 0.05). Conclusion Our results indicated that IL12B polymorphisms was associated with an increased risk for the development of JIA and JSLE in Chinese children, highlighting the involvement of inflammation in the pathogenesis of JIA and JSLE. Moreover, there was a risk haplotype in IL12B which could increase the risk of JIA.

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Impact of IL-17F 7488T/C Functional Polymorphism on Progressive Rheumatoid Arthritis: Novel Insight from the Molecular Dynamic Simulations

Cited by 13 publications

References 36 publications

A Bioinspired Self‐Healing Conductive Hydrogel Promoting Peripheral Nerve Regeneration

A Bioinspired Self‐Healing Conductive Hydrogel Promoting Peripheral Nerve Regeneration

IL12B and IL17 genes polymorphisms associated with differential susceptibility to juvenile idiopathic arthritis and juvenile-onset systemic lupus erythematosus in Chinese children

IL12B and IL17 genes polymorphisms are associated with different susceptibility to Juvenile Idiopathic Arthritis and Juvenile-onset Systemic Lupus Erythematosus in Chinese children

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