Impact of IL28 Genotypes and Modeling the Interactions of HCV Core Protein on Treatment of Hepatitis C

Hashempour, Tayebeh; Dehghani, Behzad; Musavi, Zahra; Moayedi, Javad; Hasanshahi, Zahra; Sarvari, Jamal; Hosseini, Seyed Younes; Hosseini, Ebrahim; Moeini, Mahin; Merat, Shahin

doi:10.1007/s12539-020-00382-8

Cited by 7 publications

(3 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a result, genome-wide association studies (GWAS) and other genetic investigations have focused on large panels of genes, including genetic variants of HLA, PAMPs, cytokines, chemokines, and receptor molecules, as possible causes of variability in the response to antiviral vaccines against hepatitis B, measles, rubella, influenza A, smallpox, anthrax, and mumps [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. Similar results were obtained studying the association of antiviral vaccine response with polymorphic variants in cytokine genes, such as TNF-α, IL-2, IL-4 IL-10, IL-28, IFNγ [ 13 , 14 , 15 , 16 ].…”

Section: Introductionsupporting

confidence: 75%

Age and Cytokine Gene Variants Modulate the Immunogenicity and Protective Effect of SARS-CoV-2 mRNA-Based Vaccination

et al. 2023

View full text Add to dashboard Cite

The introduction of anti-SARS-CoV-2 vaccines in late 2020 substantially changed the pandemic picture, inducing effective protection in the population. However, individual variability was observed with different levels of cellular response and neutralizing antibodies. We report data on the impact of age, gender, and 16 single nucleotide polymorphisms (SNPs) of cytokine genes on the anti-SARS-CoV-2 IgG titers measured 31 and 105 days after administration of the second dose of BNT162b2 vaccine to 122 healthy subjects from the health care staff of the Palermo University Hospital, Italy. The higher titers at 31 days were measured in the younger subjects and in subjects bearing T-positive genotypes of IL-1R1 rs2234650 or the GG homozygous genotype of IL-6 rs1800795 SNP. T-positive genotypes are also significantly more common in subjects with higher titers at day 105. In addition, in this group of subjects, the frequency of the CT genotype of IL-4 rs2243250 is higher among those vaccinated with higher titers. Moreover, these SNPs and TNFA rs1800629 are differently distributed in a group of subjects that were found infected by SARS-CoV-2 at day 105 of evaluation. Finally, subjects that were found to be infected by SARS-CoV-2 at day 105 were significantly older than the uninfected subjects. Taken together, these data seem to suggest that age and polymorphisms of key cytokines, which regulate inflammation and humoral immune response, might influence the magnitude of the antibody response to vaccination with BNT162B2, prompting speculation about the possible benefit of a genetic background-based assessment of a personalized approach to the anti-COVID vaccination schedule.

show abstract

Section: Introductionsupporting

confidence: 75%

Age and Cytokine Gene Variants Modulate the Immunogenicity and Protective Effect of SARS-CoV-2 mRNA-Based Vaccination

et al. 2023

View full text Add to dashboard Cite

show abstract

“…“Expasy's ProtParam” [ 8 ] ( Table 5 a) was employed to estimate various INT protein properties including extinction coefficient, theoretical isoelectric point (pI), molecular weight, instability index, grand average hydropathy (GRAVY), and aliphatic index [ [9] , [10] , [11] ].…”

Section: Methodsmentioning

confidence: 99%

“…Among the various models suggested by I-TASSER, the highest C-score model was selected as the best one and went through the refinement process in “GalaxyRefine” [ 16 , 34 ]. Finally, all suggested 3D structures were evaluated for the reliability, quality, and stereochemistry by “ProSA-web” [ 35 ], ‘RAMPAGE” [ 36 ], “ERRAT” [ 37 ], and “Qmean” [ 8 , 10 ] ( Table 5 d).…”

Section: Methodsmentioning

confidence: 99%

First report of computational protein–ligand docking to evaluate susceptibility to HIV integrase inhibitors in HIV-infected Iranian patients

Ghasabi

Hashempour

Khodadad

et al. 2022

Biochemistry and Biophysics Reports

Self Cite

View full text Add to dashboard Cite

Impact of IL28B (rs8099917) gene polymorphism on treatment response to Sovaldi, Daklinza, and Ribavirin in Egyptian patients with HCV infection

Eid,

Youssef,

Saudy

et al. 2023

Egyptian Journal of Basic and Applied Sciences

View full text Add to dashboard Cite

Impact of IL28 Genotypes and Modeling the Interactions of HCV Core Protein on Treatment of Hepatitis C

Cited by 7 publications

References 75 publications

Age and Cytokine Gene Variants Modulate the Immunogenicity and Protective Effect of SARS-CoV-2 mRNA-Based Vaccination

Age and Cytokine Gene Variants Modulate the Immunogenicity and Protective Effect of SARS-CoV-2 mRNA-Based Vaccination

First report of computational protein–ligand docking to evaluate susceptibility to HIV integrase inhibitors in HIV-infected Iranian patients

Impact of IL28B (rs8099917) gene polymorphism on treatment response to Sovaldi, Daklinza, and Ribavirin in Egyptian patients with HCV infection

Contact Info

Product

Resources

About