Impact of immediate post‐transplant parenteral iron therapy on the prevalence of anemia and short‐term allograft function in a cohort of pediatric and adolescent renal transplant recipients

Iorember, Franca M.; Avilés, Diego; Bamgbola, Oluwatoyin

doi:10.1111/petr.13787

Cited by 6 publications

(1 citation statement)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various factors contribute to iron deficiency in kidney-transplant recipients, including inflammation, medication, and an increased need for iron after transplantation [52]. Recent evidence suggests that routine parenteral iron treatment after kidney transplantation is linked to a lower prevalence of early-and late-onset anemia and a reduced requirement for erythropoietin-stimulating rescue agents or blood transfusions [53].…”

Section: Haematological Disorders: Leukopenia and Anemiamentioning

confidence: 99%

Adverse Drug Events after Kidney Transplantation

Rostaing,

Jouve,

Terrec

et al. 2023

JPM

View full text Add to dashboard Cite

Introduction: Kidney transplantation stands out as the optimal treatment for patients with end-stage kidney disease, provided they meet specific criteria for a secure outcome. With the exception of identical twin donor–recipient pairs, lifelong immunosuppression becomes imperative. Unfortunately, immunosuppressant drugs, particularly calcineurin inhibitors like tacrolimus, bring about adverse effects, including nephrotoxicity, diabetes mellitus, hypertension, infections, malignancy, leukopenia, anemia, thrombocytopenia, mouth ulcers, dyslipidemia, and wound complications. Since achieving tolerance is not feasible, patients are compelled to adhere to lifelong immunosuppressive therapies, often involving calcineurin inhibitors, alongside mycophenolic acid or mTOR inhibitors, with or without steroids. Area covered: Notably, these drugs, especially calcineurin inhibitors, possess narrow therapeutic windows, resulting in numerous drug-related side effects. This review focuses on the prevalent immunosuppressive drug-related side effects encountered in kidney transplant recipients, namely nephrotoxicity, post-transplant diabetes mellitus, leukopenia, anemia, dyslipidemia, mouth ulcers, hypertension, and viral reactivations (cytomegalovirus and BK virus). Additionally, other post-kidney-transplantation drugs such as valganciclovir may also contribute to adverse events such as leukopenia. For each side effect, we propose preventive measures and outline appropriate treatment strategies.

show abstract

Section: Haematological Disorders: Leukopenia and Anemiamentioning

confidence: 99%

Adverse Drug Events after Kidney Transplantation

Rostaing,

Jouve,

Terrec

et al. 2023

JPM

View full text Add to dashboard Cite

show abstract

Influence of intravenous iron on bacterial infection risk immediately following kidney transplantation

January,

Dubrawka,

Progar

et al. 2024

Pharmacotherapy

View full text Add to dashboard Cite

BackgroundKidney transplant recipients are at higher risk of infections due to immunosuppression, especially in the perioperative period after receiving induction therapy. Administration of iron has been linked to bacterial infections. This study investigated if receipt of intravenous iron at the time of kidney transplant increased bacterial infections post‐transplant.MethodsThis single‐center, retrospective study compared patients who received intravenous iron at the time of kidney transplant to those who did not. Patients were followed for 12 weeks after transplant. The primary outcome was incidence of bacterial infections following transplant; hemoglobin and transfusion needs were also examined.ResultsA total of 416 patients who received intravenous iron were compared to 416 patients who did not. Bacterial infections were similar between groups (14.4% iron group vs. 15.9% non‐iron group). Intravenous iron did not influence bacterial infections on univariable or multivariable analyses when other infection confounders were accounted for. Patients who did not receive intravenous iron required more packed red blood cell transfusions in the 3 months following transplantation, but this was driven by factors other than intravenous iron as demonstrated by a post‐hoc analysis.ConclusionsIntravenous iron did not increase the risk of bacterial infections in the immediate post‐kidney transplant setting. Bacterial infections after transplant were associated with female sex, increasing age at transplant, receipt of transfusions, and increased duration of urinary catheters.

show abstract

Anemia after kidney transplantation

Guzzo

Atkinson

2022

Pediatr Nephrol

View full text Add to dashboard Cite

Impact of immediate post‐transplant parenteral iron therapy on the prevalence of anemia and short‐term allograft function in a cohort of pediatric and adolescent renal transplant recipients

Cited by 6 publications

References 38 publications

Adverse Drug Events after Kidney Transplantation

Adverse Drug Events after Kidney Transplantation

Influence of intravenous iron on bacterial infection risk immediately following kidney transplantation

Anemia after kidney transplantation

Contact Info

Product

Resources

About