Impact of Immobilization Stress on Erythropoiesis, Alterations in the Antioxidant System, and Potential Correction with Stevia rebaudiana Bertoni in Rabbit

Abstract

This study investigates the impact of immobilization stress as a risk factor for pathological processes, with a focus on erythropoiesis and oxidative stress. Additionally, the potential therapeutic effects of Stevia rebaudiana Bertoni in mitigating these stress-induced alterations are explored. Immobilization stress was induced for 30 days, and its effects on erythropoiesis and antioxidant systems were assessed. Stevia rebaudiana Bertoni was administered to evaluate its potential for preventing and correcting the observed negative processes. Prolonged immobilization stress led to disruptions in erythropoiesis, manifested by a delay in proliferative and maturation processes and a moderate decrease in erythrocyte equilibrium. Concurrently, increased stress duration stimulated lipid peroxidation processes and inhibited antioxidant enzyme activity. The use of Stevia rebaudiana Bertoni demonstrated significant positive effects on lipid peroxidation processes and restored the activity of antioxidant enzymes, particularly peroxidase and catalase. Immobilization stress adversely affects erythropoiesis and oxidative balance, contributing to pathological processes. Stevia rebaudiana Bertoni emerges as a promising intervention, displaying the potential to attenuate the negative effects of immobilization stress through its positive influence on erythropoiesis and antioxidant mechanisms.