BackgroundUncontaminated water and adequate sanitation facilities are of major importance for limiting the incidence of infectious diseases. In Ghana, about 80% of people still do not have access to proper sanitation, including latrines, which have dramatic consequences on human health, dignity, security and the environment. Potable water coverage in the Sunyani municipality stands at 47 percent in the urban areas and 33.5 percent in the rural areas. Many of the households in the Sunyani Municipality do not have toilet facilities, putting pressure on the few existing public toilet facilities available.MethodsUsing a simple random sampling technique, a total of 500 households were selected for the study. Structured questionnaires were used to collect quantitative data. In addition, a hand-held global positioning system (GPS) receiver was used to pick geographic coordinates of various water and toilet facilities. Quantitative data were analyzed using SPSS version 25.ResultsThe results indicate inconsistencies in the spatial distribution of toilet and water facilities with an average distance of 33 meters. The study further revealed the current system of public toilets operating in the towns cannot be resource intensive to meet households’ targets because they do not satisfy sanitation needs (p<0.001). On the contrary, it tends to rather create even more problems, thereby encouraging open defecation. Also, their impact on human and environmental health needs to be taken into account.ConclusionAccess to potable water and improved toilet facility remains a challenge as most households do not have toilets within their homes. Financial constraints, distance travelled and poor condition of public toilets were the main factors determining utilization of public toilet facilities. The types of toilet facilities used in the Municipality influence disease prevalence. The prevalence of cholera, diarrhoea, typhoid, skin rashes and eye infections were as a result of improper or no washing of hands.