Nanoparticles have the ability to increase the impact of convective heat transfer in the boundary layer region. An investigation is made to analysis of magnetohdrodynamic nanofluid flow with heat and mass transfer over a vertical cone in porous media under the impact of thermal radiations and chemical reaction. In addition, thermal radiations, Hall current, and viscous and Joule dissipations and chemical reaction effects are considered. Considered three different nanoparticles types namely copper, silver, and titanium dioxide with water as base fluid. The governing equations are transformed by similarity transformations into a set of non-linear ordinary differential equations involving variable coefficients. Two numerically approaches are used to solve the transformed boundary layer system Finite Difference Method (FDM) and Chebyshev-Galerkin Method (CGM). As stated in the present analysis, it is appropriate to address a number of physical mechanisms, including velocity, temperature and concentration, as well as closed-form skin friction/mass transfer/heat transfer coefficients. Different comparisons are done with previously published data in order to validate the current study under specific special circumstances, and it is determined that there is a very high degree of agreement. The main results indicated that as the Prandtl number increases, the temperature profile decreases, but it grows for higher values of the thermophoresis parameter, Brownian motion, and Eckert number. Moreover, higher Brownian motion values lead to a less prominent concentration profile. Consequently, this speeds up the cooling process and enhances the surface’s durability and strength.