Impact of Increased Activated Protein-C Resistance, Decreased Antithrombin III Activity and Hypocomplementemia on the Gestational Outcomes of Pregnancies with MTHFR Polymorphisms

Abstract

Objective To evaluate the impact of increased Activated Protein C (APC) resistance, decreased antithrombin III activity and hypocomplementemia on the pregnancy outcomes of the patients with methylentetrahydrofolate reductase (MTHFR) polymorphisms. Methods This study was composed of 83 pregnancies with MTHFR polymorphisms. Increased APC resistance, decreased antithrombin III activity and hypocomplementemia were accepted as risk factors for poor gestational outcome. Results Having at least one risk factor resulted in significantly higher rates of “APGAR score of<7” at the first ten minutes (p=0.009). Composite adverse outcome rate was also higher in patients with at least one of the defined risk factors despite lack of statistical significance (p=0.241). Rate of newborn with an “APGAR score of<7” at first ten minutes was significantly higher at patients with hypocomplementemia (p=0.03). Conclusion Hypocomplementemia is a risk factor for poor gestational outcome in pregnancies with MTHFR polymorphisms.