Impact of initial glycosylated hemoglobin level on cardiovascular outcomes in prediabetic patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Shin, Donghun; Ahn, Jinhee; Soo, Kwang; Park, Jin Sup; Oh, Jun-Hyok; Lee, Hye Won; Hong, Ju-Yong; Kim, Bo-Won; Hong, Taek Jong

doi:10.1097/mca.0000000000000305

Cited by 22 publications

(23 citation statements)

References 28 publications

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“…[10,24,26,27] Pool analysis of these 4 study confirmed the conclusion that the elevated HbA1c level was associated with higher long-term mortality (OR 2.46, 95%CI 2.19–2.73, P < .001). A significant heterogeneity was noted ( I 2 = 98.2%, P < .001).…”

Section: Resultssupporting

confidence: 62%

“…[13,15–18,20,25–27] Meta-analysis did not find significant difference in rate of early deaths between patients with high HbA1c levels and those with low HbA1c levels (OR 1.08, 95%CI 0.92–1.27, P = .359), with no evidence of heterogeneity across the studies ( I 2 = 0%, P = .494, Fig. 3).…”

Section: Resultsmentioning

confidence: 99%

“…[18,19,23,27,28] High HbA1c levels were associated with a significantly higher risk of MI (OR 1.69, 95%CI 1.07–2.67, P = .026). No significant heterogeneity was found ( I 2 = 0%, P = .407, Fig.…”

Section: Resultsmentioning

confidence: 99%

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Glycosylated hemoglobin levels and clinical outcomes in nondiabetic patients with coronary artery disease

et al. 2017

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Section: Resultssupporting

confidence: 62%

Section: Resultsmentioning

confidence: 99%

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Glycosylated hemoglobin levels and clinical outcomes in nondiabetic patients with coronary artery disease

et al. 2017

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“…After scanning the titles, abstracts, reading full texts and hand searching the reference lists of candidate articles, we finally got 19 prospective studies including a total of 35,994 STEMI patients to evaluate the associations between HbA 1c level and their in-hospital, 30-day and long-term mortality. Among these studies, there were 13 studies from Asia [3,8,10,12,13,[23][24][25][26][27][28][29][30], 5 from Europe [11,[31][32][33][34] and 1 from North America [35]. Detailed information of the eligible studies was shown in Table 1.…”

Section: Eligible Studiesmentioning

confidence: 99%

Prognostic value of glycated hemoglobin among patients with ST-segment elevation myocardial infarction: a systematic review and meta-analysis

Hou

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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Abstract:Many studies have shown the prognostic significance of glycated hemoglobin (HbA 1c ) for overall coronary artery disease (CAD). But less is known about the role that HbA 1c played in the prognosis of patients diagnosed with ST-segment elevation myocardial infarction (STEMI).Results from previous studies were controversial. Therefore, a meta-analysis was conducted to investigate whether admission HbA 1c level was a predictor of short-and longterm mortality rates among patients diagnosed with STEMI. Relevant literatures were retrieved from the electronic databases up to March 2016. Reference lists were hand searched to identify eligible studies. Articles were included if they provided sufficient information for the calculation of pooled relative risk (RR) and its corresponding 95% confidence interval (CI). Finally, we got 19 prospective studies involving a total of 35,994 STEMI patients to evaluate the associations between HbA 1c level and their in-hospital, 30-day and long-term mortality. Among STEMI patients, HbA 1c level was not significantly associated with in-hospital mortality (RR 1.20, 95% CI 0.95-1.53, p = 0.13). However, elevated HbA 1c level was positively associated with risk of 30-day and long-term mortality (for 30-day mortality, RR 1.25, 95% CI 1.03-1.52, p = 0.02; for long-term mortality, RR 1.45, 95% CI 1.20-1.76, p < 0.01). In conclusion, our findings suggested elevated HbA 1c level among STEMI patients was an indicator of 1.25-fold 30-day mortality risk and 1.45-fold long-term mortality risk, respectively. STEMI patients with high HbA 1c level should have their chronic glucose dysregulation under intensive control.

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“…However, risk for early deaths in non-diabetic patients with CAD was not associated with high level of HbA1c. In his meta-analysis, a total of 18,041 participants were included for the analysis, [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] which showed a significantly increased risk of long-term mortality in patients with a high HbA1c level than those with a low HbA1c level (OR 1.76, 95%CI 1.44-2.16, P < .001).…”

Section: Hba1c As a Prognostic Indicatormentioning

confidence: 99%

Diabetes Mellitus And Glycosylated Hemoglobin A1c

2018

Nep. Med. J.

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Diabetes mellitus is a global health problem in 21st century. The incidence of diabetes mellitus is in rise and is estimated to be more prevalent in coming years. It is becoming one of the most common non-infectious and non-neoplastic causes of morbidity and mortality. Various complications are associated with diabetes mellitus. With control of blood glucose level, complications of diabetes mellitus can be minimized. In different time frame, different parameters and level have been used to diagnose diabetes. Glycosylated hemoglobin A1c is one of the reliable indicator of chronic hyperglycemia. In 2011, World Health Organization has included HbA1c in the diagnostic criteria. Various methods are used to detect the level of HbA1c. Glycosylated hemoglobin is being used in the management of diabetes mellitus. Various studies have shown its prognostic implication in micro and macrovascular complications. Here we discuss various methods of estimation of HbA1c, various role of HbA1c in the management of Diabetes Mellitus and limitation of the test.

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Impact of initial glycosylated hemoglobin level on cardiovascular outcomes in prediabetic patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Abstract: This study demonstrated that HbA1c level at admission was not significantly associated with cardiovascular outcomes in prediabetic Korean populations with STEMI undergoing primary PCI.

Cited by 22 publications

References 28 publications

Glycosylated hemoglobin levels and clinical outcomes in nondiabetic patients with coronary artery disease

Glycosylated hemoglobin levels and clinical outcomes in nondiabetic patients with coronary artery disease

Prognostic value of glycated hemoglobin among patients with ST-segment elevation myocardial infarction: a systematic review and meta-analysis

Diabetes Mellitus And Glycosylated Hemoglobin A1c

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