The article defines an objective list of risks and threats for the economic security and security of the information space of the state in the conditions of a full-scale invasion of the Russian Federation. The main components of threats for the economic security of Ukraine and security-oriented information environment are summarized, including: macroeconomic, production, financial, foreign economic, investment and innovation, social and food security. The systematization and analysis of current challenges and threats made it possible to identify the most significant of them – financial security, which dually reflects the growth of the state budget deficit and the increase in the state debt and expenses for its maintenance, which are the direct economic consequences of a prolonged high-intensity war, as well as factors that cause a fundamental negative influence on the economic security of Ukraine in medium and long-term dimensions. It has been proven that considering a wide range of threats for the economic security is an important step in the formation of effective strategies for the stability and state’ protection. The key directions of action to reduce threats for the food safety have been identified in the article. The manufacturing sector of Ukraine was significantly affected by the high-intensity hostilities with the aggressor country, which caused the destruction or suspension of key, largely export-oriented enterprises, mainly in the metallurgical, chemical and machine-building sectors. The impact of immediate destruction was worsened by the disruption of the logistics of both the domestic market and export routes, a significant increase in the cost of a number of important processes, the loss of part of the labor potential due to forced migrations, as well as the involvement of part of the workers in the Defense Forces, in addition, starting from the fall of 2022, – a complication with energy supply. The effectiveness of adapting the state’s investment strategy to the difficult conditions of war has been proven in the article. The priority of considering the process of risk transformation in wartime is justified, which helps to develop strategies to preserve the economic security of the country. The above makes it necessary to model and forecast the dynamics of Ukraine’s economy in the medium term in order to develop government solutions to ensure the economic security of the state, aimed at the recovery and modernization of Ukraine’s economy in the conditions of war and post-war recovery