In the widest practical and technical sense, ventilation systems are nothing more than an appropriate schematic representation of the mine's overall or individual aeration plans, which only include the specific works that are used to circulate air; other works are left out. The study analyzed the serial aeration system, giving concrete examples of serial connection of the workshops in the mines. Furthermore, the study utilized simple parallel analysis in analyzing the systems of two parallel ventilation system of the mine. In addition, the aerodynamic resistance of the ventilation system was analyzed in relation to the emergence of the COVID-19 pandemic; alongside the political, social, and economic concerns brought out by the COVID-19 pandemic. It is observed that the general resistances of the branched ventilation system through parallel branches are smaller than the minimum resistances of each branch. The findings of this study hold significant implications for managing health risks in mines during pandemics. Implementing parallel ventilation branches ensures consistent airflow distribution, minimizing areas of stagnant air where viruses may accumulate. Taking into account the values of the total resistances that are reached in the ventilation systems in the mine, it was concluded that the probability of COVID-19 over time is always decreasing. This was as a result of the medical measures that were applied for the phenomenon in question.