OBJECTIVES-To evaluate in a large, nationally representative cohort the association between high serum transferrin saturation (TS) and hospital length of stay and mortality in older adults.
DESIGN-Prospective cohort.
SETTING-Longitudinal analyses of the Third National Health and Nutrition Examination Survey linked to Medicare claims from 1991 through 2006.
PARTICIPANTS-Medicare beneficiaries aged 65 and older at baseline.MEASUREMENTS-Transferrin saturation collected on each participant at baseline was characterized as <20.0%, 20.0% to 54.9%, and 55.0% and greater. Length of stay in the hospital and death in the hospital were primary outcomes. Analyses were adjusted for age, sex, race and ethnicity, education, and severity of illness.RESULTS-Individuals hospitalized during the study period (79.4%) with high (odds ratio (OR) = 2.54, 95% confidence interval (CI) = 1.05-6.12) or low (OR = 1.31, 95% CI = 1.07-1.62) TS had a significantly greater risk of death than those with moderate TS. Individuals with high TS had longer average length of stay per hospitalization (11.1 days, (standard error, SE 1.7 days), P = .01) than those with moderate TS (8.4 (0.3) days). Individuals with high TS also had more hospital days per year (8.6 (2.0) days, P = .04) than those with moderate TS (6.7 (0.5) days). (unweighted N = 3,847, weighted N = 28,395,464).
CONCLUSION-High TS is associated with longer length of stay and death in the hospital
Conflict of Interest:There are no potential conflicts of interest for any author. The authors declare no competing financial interests.
HHS Public Access
Author Manuscript Author ManuscriptAuthor Manuscript
Author ManuscriptSerum transferrin saturation (TS) is a commonly used first-step measure in detecting hereditary iron overload in clinical practice and is recommended strategy in several guidelines. [1][2][3][4][5] Evidence from large longitudinal cohort studies in the general population shows that high TS saturation is associated with greater risk of morbidity, from cancer for example, and all-cause mortality. 6-8 A recent meta-analysis of general population studies supported the greater mortality risk associated with high levels of TS. 9In contrast, several studies have not found a link between high TS levels and mortality. 10,11 Initial steps in screening for hemochromatosis or iron overload is based on high TS is recommended based on TS greater than 45%, a level found in approximately 6% of the adult U.S. population. 12,13 It is likely in the studies that did not find an effect that their results were due to categorization of their high group according to sample quartiles or quintiles, placing many individuals with normal TS into those studies' high group (e.g., TS >29% in postmenopausal women would be considered high) and decreasing the likelihood of observing an effect of high TS. 10,11 Many people are not evaluated for high TS and are therefore not diagnosed, even though detection and treatment are easy and inexpensive. [12][13][14] It is unclear whether these deleterious effe...