Impact of interferon-induced transmembrane protein 3 gene rs12252 polymorphism on COVID-19 mortality

Ahmadi, Iraj; Afifipour, Alireza; Sakhaee, Fatemeh; Zamani, Mohammad Saber; Gheinari, Fahimeh Mirzaei; Anvari, Enayat; Fateh, Abolfazl

doi:10.1016/j.cyto.2022.155957

Cited by 19 publications

(15 citation statements)

References 34 publications

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“…Moreover, several studies included ESR as a prognostic indicator, with its clinical significance directed toward the inflammatory response. 16 , 17 …”

Section: Resultsmentioning

confidence: 99%

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An open, retrospective study on the duration of virus shedding for Shanghai patients infected with SARS‐CoV‐2 omicron variants

Zou

Zhang

Chen

et al. 2023

Health Science Reports

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According to the Shanghai Municipal Health Commission, as of May 4, 2022, there were 601,942 COVID-19 patients in Shanghai, among which 547,056 were asymptomatic. 1 The viral genomes responsible for recent infections belonged to the SARS-CoV-2 BA.2 subtype; the Omicron strain has lower rate of critical illness and mortality than the previous Delta strains. 2,3 Despite its low toxicity and mild symptomatology in most patients, this condition largely affects society, economy, work, and life. The main criterion for determining patients' recovery and release from quarantine is a negative SARS-CoV-2 nucleic acid test result. Therefore, the conversion of tests from positive to negative is highly significant for mildly symptomatic COVID-19 patients, with respect to both their treatment and their social lives after discharge. This study aimed to identify the clinical features and laboratory indicators that correlate to negative conversion time, allowing for early prediction of this important factor.

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“…Moreover, several studies included ESR as a prognostic indicator, with its clinical significance directed toward the inflammatory response. 16 , 17 …”

Section: Resultsmentioning

confidence: 99%

“…Herein, a relatively high ESR was associated with mortality from COVID‐19. Moreover, several studies included ESR as a prognostic indicator, with its clinical significance directed toward the inflammatory response 16,17 …”

Section: Resultsmentioning

confidence: 99%

An open, retrospective study on the duration of virus shedding for Shanghai patients infected with SARS‐CoV‐2 omicron variants

Zou

Zhang

Chen

et al. 2023

Health Science Reports

View full text Add to dashboard Cite

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“…By forming a chain-like structure on the cell membrane between IFITM3 protein monomers, it has been hypothesized that the IFITM3 protein physically prevents the endocytosis of a number of viruses [ 13 , 17 ]. Therefore, the IFITM3 protein's ability to combat viruses is greatly influenced by SNPs that impact the protein's function and amount of expression.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the IFITM3 protein's ability to combat viruses is greatly influenced by SNPs that impact the protein's function and amount of expression. The severity of COVID-19 is linked to the IFITM3 rs12252, which is associated with the truncated form of the IFITM3 protein [ 13 ]. The IFITM3 rs34481144 allele is positioned on the regulation region of the IFITM3 gene and the CCCTC-binding factor.…”

Section: Discussionmentioning

confidence: 99%

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Increased risk of COVID-19 mortality rate in IFITM3 rs6598045 G allele carriers infected by SARS-CoV-2 delta variant

Gholami

Sakhaee

Sotoodehnejadnematalahi

et al. 2022

Hum Genomics

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Background The interferon-induced transmembrane-protein 3 (IFITM3) is a vital component of the immune system's defense against viral infection. Variants in the IFITM3 gene have been linked to changes in expression and the risk of severe Coronavirus disease 2019 (COVID-19). This study aimed to investigate whether IFITM3 rs6598045, quantitative polymerase chain reaction (qPCR) cycle threshold (Ct) values, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are associated with an increased mortality rate of COVID-19. Methods The genotyping of IFITM3 rs6598045 polymorphism was analyzed using the amplification refractory mutation system-polymerase chain reaction in 1342 recovered and 1149 deceased patients positive for SARS-CoV-2. Results In this study, IFITM3 rs6598045 G allele as minor allele frequency was significantly more common in the deceased patients than in the recovered ones. Furthermore, the highest mortality rates were observed in Delta variant and lowest qPCR Ct values. COVID-19 mortality was associated with IFITM3 rs6598045 GG and AG in Delta variant and IFITM3 rs6598045 AG in Alpha variant. A statistically significant difference was observed in the qPCR Ct values between individuals with GG and AG genotypes and those with an AA genotype. Conclusion A possible correlation was observed between the mortality rate of COVID-19, the G allele of IFITM3 rs6598045, and SARS-CoV-2 variants. However, large-scale research is still required to validate our results.

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Relationship between CDX2 rs11568820 and EcoRV rs4516035 polymorphisms on the vitamin D receptor gene with susceptibility to different SARS‐CoV‐2 variants

Al‐Mohammedawi,

Anvari,

Fateh

2023

Cell Biology International

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Several studies have revealed that vitamin D deficiency is linked to an increased risk of developing coronavirus disease 19 (COVID‐19). In individuals with the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infections, vitamin D receptor activation is required to decrease acute respiratory distress syndrome. The purpose of this study was to examine the genotypic distribution and allelic frequencies of CDX2 rs11568820 and EcoRV rs4516035 polymorphisms in COVID‐19 patients with various SARS‐CoV‐2 variants. For genotyping of CDX2 rs11568820 and EcoRV rs4516035 polymorphisms, we used the polymerase chain reaction‐restriction fragment length polymorphism technique in 1734 and 1450 recovered and deceased patients, respectively. The results indicated the rate of COVID‐19 mortality was associated with CDX2 rs11568820 AA and GA genotypes in the Delta variant and with CDX2 rs11568820 AA in the Omicron BA.5 variant, while no association was shown in the Alpha variant. Therefore, the rate of COVID‐19 mortality was associated with EcoRV rs4516035 TC and CC genotypes in the Delta variant, while no association was shown in the Alpha and Omicron BA.5 variants. According to our analysis, the T‐G haplotype was more common in all SARS‐CoV‐2 variants. The C‐A haplotype was associated with COVID‐19 mortality in the Delta and Omicron BA.5 variants, and the T‐A haplotype was related to the Alpha variant. In conclusion, the genotype frequencies of the CDX2 rs11568820 and EcoRV rs4516035 polymorphisms between SARS‐CoV‐2 variants were significantly different between the deceased patients and recovered patients. However, more studies should be done to confirm the results.

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Impact of interferon-induced transmembrane protein 3 gene rs12252 polymorphism on COVID-19 mortality

Cited by 19 publications

References 34 publications

An open, retrospective study on the duration of virus shedding for Shanghai patients infected with SARS‐CoV‐2 omicron variants

An open, retrospective study on the duration of virus shedding for Shanghai patients infected with SARS‐CoV‐2 omicron variants

Increased risk of COVID-19 mortality rate in IFITM3 rs6598045 G allele carriers infected by SARS-CoV-2 delta variant

Relationship between CDX2 rs11568820 and EcoRV rs4516035 polymorphisms on the vitamin D receptor gene with susceptibility to different SARS‐CoV‐2 variants

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