Impact of Intermittent Fasting on Lipid Profile–A Quasi-Randomized Clinical Trial

Ahmed, Naseer; Farooq, Javeria; Siddiqi, Hasan Salman; Meo, Sultan Ayoub; Kulsoom, Bibi; Laghari, Abid Hussain; Jamshed, Humaira; Pasha, Farooq

doi:10.3389/fnut.2020.596787

Cited by 29 publications

(22 citation statements)

References 25 publications

(28 reference statements)

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“…Numerous treatments for these kinds of diseases mostly focus on diet and exercise ( 2 , 3 ). Intermittent fasting (IF) has become a popular lifestyle in recent years, though it has existed in religious and cultural contexts for a long time ( 4 , 5 ). IF is a term that covers several specific patterns ( 6 , 7 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Intermittent Fasting in Human Compared to a Non-intervention Diet and Caloric Restriction: A Meta-Analysis of Randomized Controlled Trials

Hong

et al. 2022

Front. Nutr.

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BackgroundThe popularity of applying intermittent fasting (IF) has increased as more and more people are trying to avoid or alleviate obesity and metabolic disease. This study aimed to systematically explore the effects of various IF in humans.MethodsThe randomized controlled trials (RCTs) related to IF vs. non-intervention diet or caloric restriction (CR) were retrieved in PubMed, Web of Science, Cochrane Library database, and Embase. Extraction outcomes included, but were not limited to, weight, body mass index (BMI), waist circumference (WC), fasting glucose, and triglyceride (TG).ResultsThis study includes 43 RCTs with 2,483 participants. The intervention time was at least 1 month, and the median intervention time was 3 months. Contrasting results between IF and non-intervention diet showed that participants had lower weight (weighted mean difference (WMD) = 1.10, 95% CI: 0.09–2.12, p = 0.03) and BMI after IF (WMD = 0.38, 95% CI: 0.08–0.68, p = 0.01). The WC of participants after IF decreased significantly compared with the non-intervention diet (WMD = 1.02, 95% CI: 0.06–1.99, p = 0.04). IF regulated fat mass (FM) more effectively than non-intervention diet (WMD = 0.74, 95% CI: 0.17–1.31, p = 0.01). The fat-free mass of people after IF was higher (WMD = −0.73, 95% CI: (−1.45)–(−0.02), p = 0.05). There was no difference in fasting blood glucose concentrations between participants in the after IF and non-intervention diet groups. The results of insulin concentrations and HOMA-IR, though, indicated that IF was significantly more beneficial than non-intervention diet (standard mean difference (SMD) = −0.21, 95% CI: 0.02–0.40, p = 0.03, and WMD = 0.35, 95% CI: 0.04–0.65, p = 0.03, respectively). Cholesterol and TG concentrations in participants after IF were also lower than that after a nonintervention diet (SMD = 0.22, 95% CI: 0.09–0.35, p = 0.001 and SMD = 0.13, 95% CI: 0.00–0.26, p = 0.05, respectively). IF outcomes did not differ from CR except for reduced WC.ConclusionIntermittent fasting was more beneficial in reducing body weight, WC, and FM without affecting lean mass compared to the non-intervention diet. IF also effectively improved insulin resistance and blood lipid conditions compared with non-intervention diets. However, IF showed less benefit over CR.

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Section: Introductionmentioning

confidence: 99%

Effects of Intermittent Fasting in Human Compared to a Non-intervention Diet and Caloric Restriction: A Meta-Analysis of Randomized Controlled Trials

Hong

et al. 2022

Front. Nutr.

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“…The effect of intermittent fasting (IF) on plasma lipid profile including triglycerides, total cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) are demonstrated by several recent studies (Ahmed, Farooq, & Siddiqi, 2021;Mirmiran, Bahadoran, Gaeini, Moslehi, & Azizi, 2019). Likewise, Akanji, Mojiminiyi, and Abdella (2000) reported that IF improves lipid parameters and reduces the risks of coronary heart disease in hyperlipidemic subjects, while .…”

Section: Introductionmentioning

confidence: 99%

Multidimensional evaluation of the effects of Ramadan intermittent fasting on the health of female students at the University of Bahrain

Alsowaid

Perna

Peroni

et al. 2021

Arab Journal of Basic and Applied Sciences

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This research aimed to assess the effects of Ramadan intermittent fasting (RIF) on different dimensions, namely calorie intake, fullness and hunger sensations, mental health, body weight, waist circumference (WC), quality of sleep, body composition, hydration and nutritional status among female students at the University of Bahrain. A prospective single cohort study was conducted on 20 female students. The measurements were taken before Ramadan as well as the end of each week of Ramadan. From baseline to the end of Ramadan, there was a significant decrease in body weight (À0.779 kg, CI95% À1.287, À0.271), fat mass (FM) (À1.735 kg, CI95% À2.349, À1.122) and WC (À2.158 cm, CI95% À3.902, À0.414). In addition, the HydragramV R showed an increase at week 4 (0.288% CI95% 0.72, 0.504) and nutritional status with NutrigramV R increased during the time (P trend <0.001). No changes were detected for anxiety status, hunger and fullness sensations and quality of sleep. The decrease in weight positively affected the loss of FM (r ¼ 0.597), and the increase in the Pittsburgh sleep quality index affected the reduction of FM (r¼ À0.460). The P trend <0.01 for visual analogue scales and WC showed a clear effect of time on these outcomes. The findings of this study suggest potential benefits of RIF on cardiovascular and metabolic health.

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“…Their risk factors typically encompass a range of elements linked to cardiometabolic conditions [ 1 ]. The most common risk factors and associated pathologies include metabolic syndrome [ 2 , 3 ], obesity [ 4 , 5 ], hypertriglyceridemia [ 5 , 6 ], type 2 diabetes mellitus [ 7 ], circadian disruption [ 8 ], and dyslipidemia [ 5 , 6 ]. Preventing CVDs is a primary focus for numerous public health organizations, advocating for individuals to uphold a healthy lifestyle.…”

Section: Introductionmentioning

confidence: 99%

“…Fasting is a broad term encompassing intermittent fasting (IF) [ 6 ], dietary protein restriction [ 2 ], energy restriction [ 3 ], continuous calorie restriction (CCR) [ 5 ], time-restricted eating (TRE) [ 8 ], and calorie restriction (CR) [ 10 ]. Fasting while ensuring adequate nutrition has demonstrated its effectiveness in aiding weight loss and enhancing cardiometabolic health across diverse animal species.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Fasting on Cardiovascular Diseases: A Systematic Review

Hailu,

Salib,

Savithri Nandeesha

et al. 2024

Cureus

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Among the leading causes of morbidity, disability, and death worldwide are cardiovascular diseases (CVDs). Their risk factors usually include a variety of factors associated with cardiometabolic disorders. Many public health organizations prioritize the prevention of CVDs and encourage people to maintain a healthy lifestyle. It has been shown that fasting and a healthy diet can promote weight loss and improve cardiometabolic health in various animal species. We want to know the impact of fasting on CVDs. The topic is examined in this systematic review. We looked through a wide range of online sources, including PubMed, Cochrane Library, and Google Scholar, to find randomized controlled trials (RCTs) that looked into the connection between CVDs and fasting. We included human research that has been published in English in peer-reviewed publications in the last five years, and then we screened by the title, abstract, and full-text accessibility. We picked the final 10 articles for quality assessment using Cochrane Collaboration's tool for risk-of-bias assessment of RCTs. The findings suggest that fasting is beneficial in lowering the cardiovascular risk of a population. This result holds for all types of fasting used as an intervention in the clinical trials we reviewed. The result is pronounced when fasting regimens are combined with a regular exercise routine. More comprehensive data will come from larger-scale clinical trials and case-control studies, and a thorough examination of all the potential health impacts of fasting is warranted.

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Impact of Intermittent Fasting on Lipid Profile–A Quasi-Randomized Clinical Trial

Cited by 29 publications

References 25 publications

Effects of Intermittent Fasting in Human Compared to a Non-intervention Diet and Caloric Restriction: A Meta-Analysis of Randomized Controlled Trials

Effects of Intermittent Fasting in Human Compared to a Non-intervention Diet and Caloric Restriction: A Meta-Analysis of Randomized Controlled Trials

Multidimensional evaluation of the effects of Ramadan intermittent fasting on the health of female students at the University of Bahrain

The Effect of Fasting on Cardiovascular Diseases: A Systematic Review

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