Impact of Intra-Arterial Injection Parameters on Arterial, Capillary, and Venous Time-Concentration Curves in a Canine Model

Ahmed, Azam; Deuerling-Zheng, Y; Strother, C M; Pulfer, K.; Zellerhoff, M.; Redel, Travis L.; Royalty, Kevin; Consigny, D.; Lindstrom, Mary J.; Niemann, David

doi:10.3174/ajnr.a1586

Cited by 25 publications

(14 citation statements)

References 6 publications

(7 reference statements)

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“…Our results show a smaller peak height and larger FWHM for AIFs when the injection duration was longer than 10 s. This is in accordance with the literature, shown in a simulation study and three in vivo studies in animals . All of these studies showed a smaller peak height, in combination with peak widening, for longer injection durations.…”

Section: Discussionsupporting

confidence: 92%

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Impact of contrast agent injection duration on dynamic contrast‐enhanced MRI quantification in prostate cancer

et al. 2018

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The volume transfer constant K trans, which describes the leakage of contrast agent (CA) from vasculature into tissue, is the most commonly reported quantitative parameter for dynamic contrast‐enhanced (DCE‐) MRI. However, the variation in reported K trans values between studies from different institutes is large. One of the primary sources of uncertainty is quantification of the arterial input function (AIF). The aim of this study is to determine the influence of the CA injection duration on the AIF and tracer kinetic analysis (TKA) parameters (i.e. K trans, k ep and v e).Thirty‐one patients with prostate cancer received two DCE‐MRI examinations with an injection duration of 5 s in the first examination and a prolonged injection duration in the second examination, varying between 7.5 s and 30 s. The DCE examination was carried out on a 3.0 T MRI scanner using a transversal T 1‐weighted 3D spoiled gradient echo sequence (300 s duration, dynamic scan time of 2.5 s). Data of 29 of the 31 were further analysed. AIFs were determined from the phase signal in the left and right femoral arteries. K trans, k ep and v e were estimated with the standard Tofts model for regions of healthy peripheral zone and tumour tissue.We observed a significantly smaller peak height and increased width in the AIF for injection durations of 15 s and longer. However, we did not find significant differences in K trans, k ep or v e for the studied injection durations. The study demonstrates that the TKA parameters K trans, kep and v e, measured in the prostate, do not show a significant change as a function of injection duration.

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Section: Discussionsupporting

confidence: 92%

“…The most reliable TKA estimation was achieved with high injection volumes (45 mL) . These findings are supported by animal studies . However, the influence of the injection duration on the AIF and TKA parameters has not been investigated in patient studies.…”

Section: Introductionmentioning

confidence: 75%

Impact of contrast agent injection duration on dynamic contrast‐enhanced MRI quantification in prostate cancer

et al. 2018

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“…In the absence of established protocols, we had to rely on initial animal studies. 27,37 Bolus watching seems to provide the best chance to ensure that the fill run is acquired during a steady state of parenchymal opacification while still minimizing the amount of contrast medium that is used. Therefore we used 80 mL of contrast material without a saline chase.…”

Section: Discussionmentioning

confidence: 99%

Flat Detector CT in the Evaluation of Brain Parenchyma, Intracranial Vasculature, and Cerebral Blood Volume: A Pilot Study in Patients with Acute Symptoms of Cerebral Ischemia

Struffert¹,

Yu²,

Kloska³

et al. 2010

AJNR Am J Neuroradiol

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121

125

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BACKGROUND AND PURPOSE:The viability of both brain parenchyma and vascular anatomy is important in estimating the risk and potential benefit of revascularization in patients with acute cerebral ischemia. We tested the hypothesis that when used in conjunction with IV contrast, FD-CT imaging would provide both anatomic and physiologic information that would correlate well with that obtained by using standard multisection CT techniques.

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“…Previous work has shown that within wide variation, the position of a catheter has very limited impact on the geometry of an arterial contrast medium bolus. 7 Image sequences that were suboptimal because of patient movement were excluded as were ones in which the series did not extend from a time when there was no arterial opacification through a late venous phase of the circulation. Six readers were selected to include 3 experienced observers and 3 observers with limited experience in cerebral angiography.…”

Section: Methodsmentioning

confidence: 99%

Parametric Color Coding of Digital Subtraction Angiography

Strother¹,

Bender²,

Yu³

et al. 2010

AJNR Am J Neuroradiol

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119

102

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Impact of Intra-Arterial Injection Parameters on Arterial, Capillary, and Venous Time-Concentration Curves in a Canine Model

Cited by 25 publications

References 6 publications

Impact of contrast agent injection duration on dynamic contrast‐enhanced MRI quantification in prostate cancer

Impact of contrast agent injection duration on dynamic contrast‐enhanced MRI quantification in prostate cancer

Flat Detector CT in the Evaluation of Brain Parenchyma, Intracranial Vasculature, and Cerebral Blood Volume: A Pilot Study in Patients with Acute Symptoms of Cerebral Ischemia

Parametric Color Coding of Digital Subtraction Angiography

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