Impact of intrauterine growth restriction and glucocorticoids on brain development: Insights using advanced magnetic resonance imaging

Sizonenko, Stéphane; Borradori-Tolsa, Cristina; Vauthay, Delphine M.; Lodygensky, Gregory A.; Lazeyras, François; Hüppi, Petra Susan

doi:10.1016/j.mce.2006.04.035

Cited by 47 publications

(44 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In humans lower placental levels of 11b-HSD2 have been found to be associated with intrauterine growth restriction (Dy, Guan, Sampath-Kumar, Richardson, & Yang, 2008;Glover et al, 2009). Other human studies show that synthetic glucocorticoids that cross the placenta can affect infant neurodevelopment (Sizonenko et al, 2006). On the other hand, animal studies also demonstrate long-term effects of prenatal administration of synthetic glucocorticoids, such as dexamethasone, on offspring brain development and behavior.…”

Section: Discussionmentioning

confidence: 99%

Prenatal exposure to lps leads to long‐lasting physiological consequences in male offspring

Asiaei

Solati

Salari

2011

Developmental Psychobiology

View full text Add to dashboard Cite

Growing evidence suggests that early life events are critical determinants for disorders later in life. According to a comprehensive number of epidemiological/animal studies, exposure to lipopolysaccharide, causes alteration in pro-inflammatory cytokine levels, hypothalamic-pituitary-adrenal functioning and the hormonal system which may contribute to behavioral and neurological injuries. In this study we investigated the effects of lipopolysaccharide administration on physiological parameters in pregnant dams and their male offspring aged 9 weeks. In gestational Day 10, pregnant mice were injected intrapritoneally with Salmonella enterica lipopolysaccharide to model prenatal exposure to infection. The following results were obtained for offspring from dams stressed during pregnancy: (a) reduced anxiety-related behavior in the elevated plus maze; (b) reduced food and water intake; (c) reduced body weight from birth up to postnatal Day 40. The observed data provide experimental evidence showing that prenatal stress can have complex and long-lasting physiological/behavioral consequences in offspring.

show abstract

Section: Discussionmentioning

confidence: 99%

Prenatal exposure to lps leads to long‐lasting physiological consequences in male offspring

Asiaei

Solati

Salari

2011

Developmental Psychobiology

View full text Add to dashboard Cite

show abstract

“…Accepted August 5, 2011 ever, information on changes in sex steroids, fetal fluids and their composition, and weights of fetal organs is lacking. Because the ewe is a valued animal model for study of interactions among genes, nutrition, and the uterine enviromnent that affect pregnancy outcomes Eleftheriades et al, 2006;Gicquel and Le Bouc, 2006), and metabolic insults that alter fetal growth and adult onset of metabolic disease (Sizonenko et al, 2006;Wu et al, 2006;Mari and Hanif, 2007), it is important to understand the patterns of intrauterine fetal growth that lead to perinatal morbidity and mortality, and metabolic syndrome in adults (Barker and Glark, 1997;Symonds et al, 2001;Ozanne and Hales, 2002;Ergaz et al, 2005;Fowden et al, 2006). Intrauterine growth of the fetus directly affects reproductive performance of domestic species (Ergaz et al, 2005;Wu et al.…”

Section: Introductionmentioning

confidence: 99%

Growth and development of the ovine conceptus1

Bazer

Spencer

Thatcher

2012

Journal of Animal Science

View full text Add to dashboard Cite

This study was designed to characterize development of the ovine conceptus throughout gestation to establish the temporal relationships in metabolites, electrolytes, fluid volumes within the placenta, and hormonal changes with fetal growth. Length and weight of placentae, weight of cotyledons, and uterine weight increased between d 25 and 80 of gestation in advance of increases in fetal growth between d 80 and 140 of gestation. Allantoic fluid volumes changed (P < 0.01) between d 25 (21 mL) and 40 (91 mL), decreased to d 70 (32 mL), and then increased to d 140 (438 mL). Concentrations and total amounts of proteins in allantoic fluid were reduced between d 25 and 50, but total protein increased (P < 0.01) from d 40 (63 mg) to d 140 (2,991 mg). Concentrations of fructose in allantoic fluid varied between 2 and 6 mg/mL throughout gestation, but total fructose increased (P < 0.01) between d 25 (46 mg) and d 120 (679 mg). Concentrations of glucose ranged from 0.1 to 0.3 mg/mL, and total glucose increased (P < 0.05) from d 25 (3 mg) to d 140 (63 mg) of gestation. Amniotic fluid volume increased (P < 0.01) between d 30 and 140. Concentrations of estrogens in allantoic fluid, maternal uterine artery, and uterine vein increased (P < 0.01) with advancing pregnancy, and concentrations of progesterone in allantoic fluid (P < 0.07) and plasma (P < 0.05) were affected by day of gestation. Concentrations of glucose were greater (P < 0.05) in uterine artery than uterine vein, but concentrations of electrolytes and osmolarity of plasma were not affected by day of gestation. Increases in weights of fetal organs were proportional to increases in fetal weight during gestation. Results of the present study of conceptus growth and development highlight areas of needed research and provide benchmarks for comparisons when evaluating effects of various treatments, environmental conditions, and epigenetics on successful outcomes of pregnancy in sheep.

show abstract

“…Cortisol, the primary glucocorticoid of the primate hypothalamic-pituitary-adrenal (HPA) axis, is essential for normal fetal development. Cortisol is required for the maturation and preparation of the lungs for the extra-uterine environment [41], fetal central nervous system development [48], and the growth of the fetus and induction of enzymes important for the preparation for extra-uterine life [10]. Glucocorticoids play a pivotal role in lung maturation, and glucocorticoids have long been used clinically to enhance/alter the maturation of tissues and organs, often to develop the lungs in cases where mothers are at high risk for preterm deliveries [23].…”

Section: Introductionmentioning

confidence: 99%

Natural variation in gestational cortisol is associated with patterns of growth in marmoset monkeys (Callithrix geoffroyi)

Mustoe

Birnie

Korgan

et al. 2012

General and Comparative Endocrinology

View full text Add to dashboard Cite

High levels of prenatal cortisol have been previously reported to retard fetal growth. Although cortisol plays a pivotal role in prenatal maturation, heightened exposure to cortisol can result in lower body weights at birth, which have been shown to be associated with adult diseases like hypertension and cardiovascular disease. This study examines the relationship between natural variation in gestational cortisol and fetal and postnatal growth in marmoset monkeys. Urinary samples obtained during the mother’s gestation were analyzed for cortisol. Marmoset body mass index (BMI) was measured from birth through 540 days in 30- or 60-day intervals. Multi-level modeling was used to test if marmoset growth over time was predicted by changes in gestational cortisol controlling for time, sex, litter, and litter size. The results show that offspring exposed to intra-uterine environments with elevated levels of cortisol had lower linear BMI rates of change shortly after birth than did offspring exposed to lower levels of cortisol, but exhibited a higher curvilinear growth rate during adolescence. Average daily change in gestational cortisol during the first trimester had a stronger relationship with postnatal growth than change during the third trimester. Higher exposure to cortisol during gestation does alter developmental trajectories, however there appears to be a catch-up period during later post-natal growth. These observations contribute to a larger discussion about the relationship of maternal glucocorticoids on offspring development and the possibility of an earlier vulnerable developmental window.

show abstract

Impact of intrauterine growth restriction and glucocorticoids on brain development: Insights using advanced magnetic resonance imaging

Cited by 47 publications

References 63 publications

Prenatal exposure to lps leads to long‐lasting physiological consequences in male offspring

Prenatal exposure to lps leads to long‐lasting physiological consequences in male offspring

Growth and development of the ovine conceptus1

Natural variation in gestational cortisol is associated with patterns of growth in marmoset monkeys (Callithrix geoffroyi)

Contact Info

Product

Resources

About