Impact of intrauterine infusion of<scp>Platelets‐Rich</scp>plasma on endometritis and reproductive performance of Arabian mare

Ghallab, Rezk Said; El-Beskawy, Mohamed; El-Shereif, Abdelghany A; Rashad, Amr M.A.; Elbehiry, Mohamed

doi:10.1111/rda.14329

Cited by 7 publications

(1 citation statement)

References 20 publications

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“…Activated PRP releases cytokines and growth factors, like transforming growth factor-beta, fibroblast growth factor, insulin-like growth factors 1 and 2, VEGF and epidermal growth factor [49]. Besides human applications, PRP is used in animal reproductive medicine to treat endometritis and improve follicular development, oocyte competence and the uterine environment for embryo implantation [50][51][52].…”

Section: Platelet-rich Plasma (Prp) Treatmentmentioning

confidence: 99%

Thrombocytes and Platelet-Rich Plasma as Modulators of Reproduction and Fertility

Nagy,

Kovács,

Sulyok

et al. 2023

IJMS

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Thrombocytes play an essential role in hemostasis and thrombosis. Moreover, the controlled activation of thrombocytes is required in reproduction and fertility. The platelet-activating factor and the controlled activation of platelets have important roles in folliculogenesis, ovulation, placental development, implantation and embryo development. Activated platelets accumulate in the follicular vessels surrounding the follicle and, due to its released soluble molecules (factors, mediators, chemokines, cytokines, neurotransmitters), locally increase oocyte maturation and hormone secretion. Furthermore, activated platelets are involved in the pathogenesis of ovarian hyperstimulation syndrome (OHSS) and preeclampsia. Low-dose aspirin can prevent OHSS during ovulation induction, while intrauterine or intraovarian administration of platelet-rich plasma (PRP) increases the endometrium thickness and receptivity as well as oocyte maturation. Activated thrombocytes rapidly release the contents of intracellular granules and have multiple adhesion molecules and receptors on their surface. Considering the numerous homeostatic endocrine functions of thrombocytes, it is reasonable to suppose a platelet-associated regulatory system (PARS) in reproduction. Although we are far from a complete understanding of the regulatory processes, the results of PARS research and the therapeutic application of aspirin and PRP during in vitro fertilization are promising.

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Section: Platelet-rich Plasma (Prp) Treatmentmentioning

confidence: 99%

Thrombocytes and Platelet-Rich Plasma as Modulators of Reproduction and Fertility

Nagy,

Kovács,

Sulyok

et al. 2023

IJMS

View full text Add to dashboard Cite

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Isolation of lactic acid bacteria from the reproductive tract of mares as potentially beneficial strains to prevent equine endometritis

Silva,

Castañares,

Mouguelar

et al. 2024

Vet Res Commun

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Endometritis, the infection and/or in ammation of the endometrium, is the leading cause of subfertility in mares, and therefore responsible for major economic losses in the horse industry worldwide. It is generally treated with uterine lavages combined with ecbolic agents and local or systemic antibiotics. However, since antibiotic overuse has been associated with antimicrobial resistance in mares with persistent endometritis, new prevention and treatment alternatives are needed. One such alternative could be the use of probiotic lactic acid bacteria (LAB) isolated from the host. Thanks to their species speci city, indigenous microbiota may restore ecological equilibrium within the host, and therefore, help prevent infections and improve physiological functions. In the present study, 257 bacterial strains were isolated from 77 healthy mares, and 88.76% (n = 228) of them were phenotypically classi ed as LAB. Within this group, 65.79% were able to inhibit at least one strain from each of the genera that most commonly cause equine endometritis (S. zooepidemicus, E. coli, and Staphylococcus spp.). Five strains (RCE11, RCE20, RCE91, RCE99, and RCE167) were selected on the basis of their bene cial properties: ability to autoaggregate and adhere to equine epithelial cells, high inhibition of and co-aggregation with all the bacteria isolated from clinical cases of endometritis evaluated, and negative co-inhibition between one another. All ve were nally identi ed as Enterococcus spp., namely E. faecium (two strains), E. hirae (two strains), and E. gallinarum (one strain). Further studies will assess their safety and biotechnological potential for the design of a multi-strain probiotic formula to prevent equine endometritis.

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Use of equine embryo -derived mesenchymal stromal cells and their extracellular vesicles as a treatment for persistent breeding-induced endometritis in susceptible mares

Hollinshead,

Hanlon,

Hou

et al. 2024

Journal of Equine Veterinary Science

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Impact of intrauterine infusion ofPlatelets‐Richplasma on endometritis and reproductive performance of Arabian mare

Cited by 7 publications

References 20 publications

Thrombocytes and Platelet-Rich Plasma as Modulators of Reproduction and Fertility

Thrombocytes and Platelet-Rich Plasma as Modulators of Reproduction and Fertility

Isolation of lactic acid bacteria from the reproductive tract of mares as potentially beneficial strains to prevent equine endometritis

Use of equine embryo -derived mesenchymal stromal cells and their extracellular vesicles as a treatment for persistent breeding-induced endometritis in susceptible mares

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