Impact of intrauterine tobacco exposure on fetal telomere length

Salihu, Hamisu M.; Pradhan, Anupam; King, Lindsey; Paothong, Arnut; Nwoga, Chiaka; Marty, Phillip J.; Whiteman, Valerie E.

doi:10.1016/j.ajog.2014.08.026

Cited by 70 publications

(66 citation statements)

References 38 publications

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“…However, because our cohort included few children with prenatal tobacco exposure, these results should be interpreted cautiously. Similar results for prenatal smoke exposure were observed by Theall et al (2013) and by Salihu et al (2014). The problem of tobacco-induced telomere loss, most likely due to reactive oxygen species generation, was observed in adults as well (Valdes et al, 2005).…”

Section: Discussionsupporting

confidence: 88%

“…et al, 2014a;Zhang et al, 2013). In addition, both prenatal exposure and later exposure to tobacco smoke were associated with shorter telomere length (Theall et al, 2013;Babizhayev and Yegorov, 2011;Valdes et al, 2005;Salihu et al, 2014). Therefore, telomere length is a promising biomarker of exposure and of susceptibility to disease (Silins and Hogberg, 2011).…”

Section: Introductionmentioning

confidence: 93%

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Telomere length in children environmentally exposed to low-to-moderate levels of lead

Pawlas

Płachetka

Kozłowska

et al. 2015

Toxicology and Applied Pharmacology

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 93%

Telomere length in children environmentally exposed to low-to-moderate levels of lead

Pawlas

Płachetka

Kozłowska

et al. 2015

Toxicology and Applied Pharmacology

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“…Environmental exposure to lead in children appears to be associated with shorter telomeres [98], as prenatal exposure to toxic agents also seems to be a predictor of telomere imbalance. Neonatal umbilical cord blood showed a positive association between shortened fetal telomere length and smoking during pregnancy [99]. Even with the concept that high variation in telomere length between individuals is already present before birth and could increase due to environmental exposure, 128 Indian newborns from high-level natural background radiation areas showed no evidence of telomere length attrition [100].…”

Section: Occupational and Environmental Exposuresmentioning

confidence: 99%

“…Yet, most studies with regard to telomere length in children are conducted on the effects of environmental exposure and socioeconomic and psychological status [72,73,98,99,101,103]. A recently published study analyzed whether nutritional factors are associated with telomere length in children [112].…”

Section: What Can Be Done To Help Maintain Telomere Length?mentioning

confidence: 99%

Telomere Length and Its Relation to Human Health

Kahl¹,

Silva²

2016

Telomere - A Complex End of a Chromosome

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Telomeres are complex nucleotide sequences that cap the end of chromosomes from degradation, unwanted recombination-fusion, inappropriate activation of DNA damage response and play a critical role in cell division and chromosome stability. There is growing evidence that telomere stability can be affected by occupational and environmental exposure, as some of these factors have been correlated with increase in inflammation, oxidative stress, DNA damage, chromosome aberration, and epigenetic alterations. Both extremely short and long telomeres have been associated with neurodegenerative, cardiovascular diseases (CVD) and cancer risk. Occupational and environmental exposure to several synthetic and natural chemicals has been found to be associated with changes in telomere length, although the molecular mechanism is not fully understood. Telomeric DNA is relatively less capable of repair, resulting in accelerated shortening during the cell cycle and replicative senescence. It is recognized that diet plays an important role in telomere maintenance. Prevention of exposure to environmental and occupational hazards as well as psychological stressors can reduce the risk of telomere instability. This review provides a broad evaluation of the associated mechanism between human health and environmental and occupational exposure with telomere length, including recent findings and future perspectives.

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“…8 Recently, our team and others have opened a new frontier in the science of fetal programming by demonstrating that prenatal adverse exposures (eg, maternal tobacco use and sleep disturbances) influence telomere length, a biomarker that has been linked to aging and life expectancy. 9,10 Although more studies are needed to refine our understanding of the role of telomere length in fetal biology, we summarize the advances made so far in this promising field and propose future research directions.…”

Section: Introductionmentioning

confidence: 99%

Telomere length and fetal programming: A review of recent scientific advances

Whiteman¹,

Goswami²,

Salihu

2017

American J Rep Immunol

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We sought to synthesize a comprehensive literature review comprising recent research linking fetal programming to fetal telomere length. We also explored the potential effects fetal telomere length shortening has on fetal phenotypes. Utilizing the PubMed database as our primary search engine, we retrieved and reviewed 165 articles of published research. The inclusion criteria limited the articles to those that appeared within the last ten years, were pertinent to humans, and without restriction to language of publication. Our results showed that socio-demographic factors like age, sex, genetic inheritance, and acquired disease impact telomere length. Further, we found several maternal characteristics to be associated with fetal telomere length shortening, and these include maternal chemical exposure (eg, tobacco smoke), maternal stress during pregnancy, maternal nutritional and sleeping disorders during pregnancy as well as maternal disease status. Due to paucity of data, our review could not synthesize evidence directly linking fetal phenotypes to telomere length shortening.Although the research summarized in this review shows some association between determinants of intrauterine programming and fetal telomere length, there is still significant work that needs to be done to delineate the direct relationship of telomere attrition with specific fetal phenotypes. K E Y W O R D Sfetal phenotypes, fetal programming, telomere length

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Impact of intrauterine tobacco exposure on fetal telomere length

Cited by 70 publications

References 38 publications

Telomere length in children environmentally exposed to low-to-moderate levels of lead

Telomere length in children environmentally exposed to low-to-moderate levels of lead

Telomere Length and Its Relation to Human Health

Telomere length and fetal programming: A review of recent scientific advances

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