Impact of intravenous infusion of labetalol combined with magnesium sulfate versus hydralazine combined with magnesium sulfate on fetomaternal hemodynamics in severe preeclampsia

Abdelrahman, Tamer Nabil; Youssry, Mohamed; Radwan, Ahmed M.; Ahmed, Anis

doi:10.1186/s42077-019-0020-3

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…These results suggest that magnesium sulfate combined with labetalol is effective in treating ES-PE and can relieve the clinical symptoms of patients. In the study by Abdelrahman et al ( 26 ), 25 ES-PE patients treated with magnesium sulfate combined with labetalol or hydralazine presented good tolerance to the drug treatment, and their blood pressure was effectively and safely controlled. In addition, the fetal heart rate was not significantly changed after treatment, which is similar to the results of the present study.…”

Section: Discussionmentioning

confidence: 99%

Effect of magnesium sulfate combined with labetalol on serum sFlt‑1/PlGF ratio in patients with early‑onset severe pre‑eclampsia

2020

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The aim of the present study was to investigate the therapeutic effect of magnesium sulfate combined with labetalol on the early-onset severe pre-eclampsia (ES-PE) and explore the role of soluble fms-like tyrosine kinase-1 (sFlT-1), placental growth factor (PlGF), and sFlt-1/PlGF ratio in the treatment. A total of 164 ES-PE patients admitted to the Maternity and Child Health Care Hospital of Hubei (Wuhan, China) were assigned to this observational study. Among them, 83 patients were enrolled in group A and treated with magnesium sulfate combined with labetalol hydrochloride, and 81 patients were enrolled in group B and treated with magnesium sulfate. The therapeutic effect, adverse reactions and pregnancy outcomes in the two groups were analyzed. Serum sFlt-1 and PlGF concentrations, before and after treatment, were measured by enzyme-linked immunosorbent assay (ELISA). Receiver operating characteristic (ROC) curve analysis was performed to assess the predictive value of pre-treatment serum sFlt-1/PlGF ratio for the clinical outcome. The effective rate was significantly higher in group A than that in group B. Group A presented superior pregnancy outcomes over group B. The serum sFlt-1 concentration and sFlt-1/PlGF ratio after treatment were significantly lower than those before treatment in groups A and B, whereas PlGF concentration was significantly higher after treatment in both groups. After treatment, group A had markedly lower serum sFlt-1 concentration and sFlt-1/PlGF ratio than group B, and markedly higher PlGF concentration than group B. The area under curve (AUC) of serum sFlt-1/PlGF ratio before treatment for the prediction of the clinical efficacy was 0.737. In conclusion, magnesium sulfate combined with labetalol could be effectively used for the treatment of ES-PE. The results of ELISA revealed that the balance of sFlT-1 and PlGF was improved after treatment and the sFlT-1/PlGF ratio was decreased. The assessment of sFlt-1/PlGF ratio before treatment was shown to have a certain predictive value for the efficacy of ES-PE treatment.

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Section: Discussionmentioning

confidence: 99%

Effect of magnesium sulfate combined with labetalol on serum sFlt‑1/PlGF ratio in patients with early‑onset severe pre‑eclampsia

2020

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Fetal hemoglobin as a predictor in cases of pre-eclampsia

Elrefaei¹,

Zakarya

Motaal

et al. 2022

Al-Azhar Assiut Medical Journal

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Background and Aim Fetal hemoglobin (Hb) has been described as a new predictive biomarker for pre-eclampsia and has also been hypothesized to be a causative factor. Interestingly, the heme scavenger and antioxidant α-microglobulin increases in parallel with fetal Hb. The aim was to measure the level of fetal Hb in the serum of pregnant women with pre-eclampsia. Patients and methods This a prospective study that was conducted on 100 pregnant women selected from the Obstetrics and Gynecology Department of Al-Hussein University Hospital. Results There was a significant increase in fetal Hb in the patient group more than the control group. The fetal Hb shows a high sensitivity, specificity, and accuracy in prediction of pre-eclampsia and eclampsia. Conclusion Fetal Hb was significantly higher in patients with eclampisa and pre-eclampsia. Moreover, it can be used as a predictive marker for both eclampisa and pre-eclampsia.

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Impact of intravenous infusion of labetalol combined with magnesium sulfate versus hydralazine combined with magnesium sulfate on fetomaternal hemodynamics in severe preeclampsia

Cited by 2 publications

References 31 publications

Effect of magnesium sulfate combined with labetalol on serum sFlt‑1/PlGF ratio in patients with early‑onset severe pre‑eclampsia

Effect of magnesium sulfate combined with labetalol on serum sFlt‑1/PlGF ratio in patients with early‑onset severe pre‑eclampsia

Fetal hemoglobin as a predictor in cases of pre-eclampsia

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