Impact of Ischemic Preconditioning on Outcome in Clinical Liver Surgery: A Systematic Review

Chu, Michael J. J.; Vather, Ryash; Hickey, Anthony J. R.; Phillips, Anthony R. J.; Bartlett, Adam

doi:10.1155/2015/370451

Cited by 14 publications

(11 citation statements)

References 57 publications

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“…The studies with steatotic livers are quite heterogeneous as a technique and duration of ischemia, form of induction of steatosis, certain results, fact that limit the conclusions. In studies with hypothermic ischemia lasting more than 6 hours, PCI had minimal results, generally 31 .…”

Section: Conditionalities Pharmacological Options and Emerging Optionsmentioning

confidence: 99%

“…In studies performed with cirrhotic livers, the parameters remained similar between the cirrhotic groups, with IR or PCI induction 30 . Recent studies confirm the efficacy of the process in reducing hepatocellular injury, but the results are discrepant due to the lack of standardization and the variability in the time of ischemia, which reinforces the need for a protocol to allow the comparison between studies [31][32] . During PCI, the inducible factor of hypoxia-1α (HIF-1α), a substance directly related to hepatocellular protection, is induced.…”

Section: Conditionalities Pharmacological Options and Emerging Optionsmentioning

confidence: 99%

See 1 more Smart Citation

Liver ischemia and reperfusion injury. Pathophysiology and new horizons in preconditioning and therapy

Nakazato

Victorino²,

Fina³

et al. 2018

Acta Cir. Bras.

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It is well known that during hepatic operative procedures, it is often critical that the irrigation is interrupted to avoid possible bleeding, blood transfusions, variable intensities, and their short and long-term consequences. It was believed in the past that the flow interruption should not exceed 20 minutes, which limited the use of this maneuver. However, it has been postulated that ischemia could be maintained for more than 60 minutes in healthy livers. The present paper review includes: 1) A brief introduction to justify the rationale of the review design; 2) Aspects of the pathophysiology of the three stages of the liver ischemia-reperfusion injury; 3) The innate and acquired immunity; 4) Oxidative stress; 5) Apoptosis and autophagy, Some essential biomarkers (Tumor Necrosis Factor-α, nitric oxide, metalloproteinases); and, finally; 6) Preventive ("cheating") strategies, non-pharmacological and pharmacological options to treat the liver IR injury.

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Section: Conditionalities Pharmacological Options and Emerging Optionsmentioning

confidence: 99%

Section: Conditionalities Pharmacological Options and Emerging Optionsmentioning

confidence: 99%

Liver ischemia and reperfusion injury. Pathophysiology and new horizons in preconditioning and therapy

Nakazato

Victorino²,

Fina³

et al. 2018

Acta Cir. Bras.

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“…IP surgical application, however, has the disadvantage of inducing trauma to major vessels and stress to the target organ [ 9 ]. Moreover the contrasting outcomes of the first clinical studies, the different protocols of IP application in humans, and the variable clinical settings have not allowed a definitive demonstration of the benefit of the clinical application of IP [ 9 – 13 ].…”

Section: Hepatic Ischemic Preconditioningmentioning

confidence: 99%

Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype

Alchera

Imarisio

Mandili

et al. 2015

BioMed Research International

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Ischemic preconditioning (IP) of the liver by a brief interruption of the blood flow protects the damage induced by a subsequent ischemia/reperfusion (I/R) preventing parenchymal and nonparenchymal liver cell damage. The discovery of IP has shown the existence of intrinsic systems of cytoprotection whose activation can stave off the progression of irreversible tissue damage. Deciphering the molecular mediators that underlie the cytoprotective effects of preconditioning can pave the way to important therapeutic possibilities. Pharmacological activation of critical mediators of IP would be expected to emulate or even to intensify its salubrious effects. In vitro and in vivo studies have demonstrated the role of the adenosine A2a receptor (A2aR) as a trigger of liver IP. This review will provide insight into the phenotypic changes that underline the resistance to death of liver cells preconditioned by pharmacological activation of A2aR and their implications to develop innovative strategies against liver IR damage.

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“…Preconditioning the liver with ischemia involves a brief period of portal triad clamping usually between 5–15 minutes followed by a brief period of reperfusion (10–20 min) before a prolonged period of ischemia. Until recently, IPC was one of the widely used protective measures with moderate success . The exact mode of action of the IPC in the prevention of post operative hepatic complication has not yet been fully comprehended .…”

Section: Introductionmentioning

confidence: 99%

“…Until recently, IPC was one of the widely used protective measures with moderate success . The exact mode of action of the IPC in the prevention of post operative hepatic complication has not yet been fully comprehended . Over the years, studies with experimental and animal models have reported numerous positive effects of IPC on the alleviation of hepatic IR injury and improved post‐operative hepatic functioning.…”

Section: Introductionmentioning

confidence: 99%

Preconditioning methods in the management of hepatic ischemia reperfusion‐ induced injury: Update on molecular and future perspectives

Arumugam

Thirunavukkarasu

2016

Hepatology Research

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Hepatic IR (ischemia reperfusion) injury is a commonly encountered obstacle in the post-operative management of hepatic surgery. Hepatic IR occurs during 'Pringle maneuver' for reduction of blood loss or during a brief period of cold storage followed by reperfusion of liver grafts. The stress induced during hepatic IR, triggers a spectrum of cellular responses leading to the varying degrees of hepatic complications which in turn affect the post operative care. Different preconditioning methods either activate or subdue different sets of molecular signals, resulting in varied levels of protection against hepatic IR injury. Yet, there is a serious lacuna in the knowledge regarding the choice of preconditioning methods and the resulting molecular changes in order to assess the efficiency and choice of these methods correctly. This review provides an update on the various preconditioning approaches such as surgical/ischemic, antioxidant, pharmaceutical and genetic preconditioning strategies published during last six years (2009-2015). Further, we discuss the attenuation or inhibition of specific inflammatory, apoptotic and necrotic markers in the various experimental models of liver IR subjected to different preconditioning strategies. While enlisting the controversies in the ischemic preconditioning strategy, we bring out the uncertainties in the existing molecular targets and their reliability in the attenuation of hepatic IR injury. Future research studies would include the novel preconditioning strategies employ i) the targeted gene silencing of key molecular targets inducing IR, ii) hyper expression of beneficial molecular signals against IR via gene transfer techniques. The above studies would see the combination of these latest techniques with the established preconditioning strategies for better post-operative hepatic management.

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Impact of Ischemic Preconditioning on Outcome in Clinical Liver Surgery: A Systematic Review

Cited by 14 publications

References 57 publications

Liver ischemia and reperfusion injury. Pathophysiology and new horizons in preconditioning and therapy

Liver ischemia and reperfusion injury. Pathophysiology and new horizons in preconditioning and therapy

Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype

Preconditioning methods in the management of hepatic ischemia reperfusion‐ induced injury: Update on molecular and future perspectives

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