Impact of isolated single umbilical artery on pregnancy outcome and delivery in full‐term births

Shen, Nan; Zhang, Weiyuan; Li, Guanghui

doi:10.1111/jog.12921

Cited by 9 publications

(4 citation statements)

References 19 publications

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“…[7,8] There is a discrepancy between the reported frequencies of adverse pregnancy outcomes in studies comparing SUA and DUA cases. [5,7,[9][10][11][12][13][14][15][16] For example, compared with DUA, some studies reported higher rates of IUGR, [5,10,11] preterm delivery, [9,10] and lower 1-minute and 5-minute Apgar scores, [15] whereas others reported similar rates of IUGR, [12,13] preterm delivery, [14] and 1-minute and 5-minute Apgar scores. [16] Many studies reporting accompanying structural malformations in SUA cases pointed out affected organs rather than exact abnormalities.…”

Section: Introductionmentioning

confidence: 99%

“…[5,7,[9][10][11][12][13][14][15][16] For example, compared with DUA, some studies reported higher rates of IUGR, [5,10,11] preterm delivery, [9,10] and lower 1-minute and 5-minute Apgar scores, [15] whereas others reported similar rates of IUGR, [12,13] preterm delivery, [14] and 1-minute and 5-minute Apgar scores. [16] Many studies reporting accompanying structural malformations in SUA cases pointed out affected organs rather than exact abnormalities. [1,2,5] In addition, there is a scarcity of studies evaluating the outcomes of SUA with additional structural and chromosomal malformations.…”

Section: Introductionmentioning

confidence: 99%

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Prenatal and neonatal outcomes of pregnancies diagnosed with fetal single umbilical artery

Obut¹,

Oncu²,

Çelik³

et al. 2021

Perinatal J

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Objective To investigate the associated anomalies and outcomes of fetuses diagnosed as having a single umbilical artery (SUA) which were reported inconsistently in previous studies. Methods The data of 82 pregnancies with fetal SUA, 35 of which were complex, and 47 isolated SUA (iSUA) and 100 pregnancies with fetal double umbilical arteries (DUA) between June 2018 and July 2020 were retrieved. We compared the maternal characteristics, and pregnancy and fetal outcomes of the three groups (iSUA, SUA, and DUA). Results Of 82 fetuses with SUA, 35 had 64 major structural abnormalities. 20 of these 35 fetuses (57.1%) had cardiovascular malformations, 12 (34.2%) had central nervous, 10 (28.5%) had genitourinary, and eight (22.8%) had gastrointestinal system malformations. Isolated SUA was present in SUA. Compared with the 100 DUA fetuses, SUA was a risk for intrauterine growth restriction (IUGR), preterm delivery, Apgar scores of <7, and admission to the neonatal intensive care unit. Having fetal chromosomal or structural abnormalities, was a risk for amnion fluid abnormality, pregnancy termination, intrauterine fetal death, early neonatal death, and a low live birth ratio in SUA cases. Conclusion SUA has an increased rate of fetal structural and chromosomal abnormalities. Among them, the most detected one is cardiac and the second most common one is central nervous system malformations. Pregnancies with fetal SUA have increased risk for IUGR, preterm delivery, low Apgar scores, and admission to the neonatal intensive care unit. The presence of additional structural or chromosomal malformations increases the rate of these adverse pregnancy risks. Thus, these cases warrant dedicated fetal ultrasonographic organ screening and close prenatal follow-up.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prenatal and neonatal outcomes of pregnancies diagnosed with fetal single umbilical artery

Obut¹,

Oncu²,

Çelik³

et al. 2021

Perinatal J

View full text Add to dashboard Cite

show abstract

“…Although the mechanism responsible for the formation of one versus two umbilical arteries is not fully understood, 1 emerging data suggest that this finding may be associated with fetal anomalies as well as with adverse perinatal outcomes. 1,2 Single umbilical artery (SUA) occurs in roughly 0.3 to 1% of live births, 3,4 with varying prevalence among different ethnic populations. 2 SUA can be discovered either by routine prenatal ultrasonography starting from 13 weeks' gestation 5 or by direct visualization of the cord immediately following delivery.…”

mentioning

confidence: 99%

“…These may include neural tube, cardiac, respiratory, genitourinary (GU), gastrointestinal, and musculoskeletal defects. 1,2 Although, by its very definition, iSUA is an isolated finding, recent studies…”

mentioning

confidence: 99%

Isolated Single Umbilical Artery as a Risk Factor for Urinary Tract Infections in Childhood

et al. 2019

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Objective To determine whether isolated single umbilical artery (iSUA), even absent identifiable genitourinary (GU) abnormalities, increases the risk of GU infection during childhood. Study Design Retrospective population-based comparison of fetuses with iSUA versus normal three-vessel cords. Fetuses with growth restriction, prematurity, multiple gestations, and anatomical or chromosomal anomalies were excluded. The primary outcome was hospital-associated GU infection during the first 18 years of life. Kaplan–Meier's survival curves were used to assess cumulative risk; Cox's multivariable models were used to adjust for confounders. Results Among 227,599 term singleton deliveries, children with iSUA (n = 729) had a higher incidence (1.8 vs. 0.6%, p < 0.001) and cumulative incidence (log-rank test, p < 0.001) of hospital-associated GU infection. The Cox's models confirmed these findings (hazard ratio: >2.82, confidence interval: 1.63–4.87 in composite models). Conclusion iSUA represents an independent risk factor for GU infection. Urinary tract imaging may be warranted.

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Ambient air pollution and the risk of stillbirth: a population-based prospective birth cohort study in the coastal area of China

Zang

Cheng

Wenya

et al. 2019

Environ Sci Pollut Res

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Impact of isolated single umbilical artery on pregnancy outcome and delivery in full‐term births

Abstract: An ISUA is associated with an adverse pregnancy outcome; however does not decrease the rate of vaginal delivery in full-term births.

Cited by 9 publications

References 19 publications

Prenatal and neonatal outcomes of pregnancies diagnosed with fetal single umbilical artery

Prenatal and neonatal outcomes of pregnancies diagnosed with fetal single umbilical artery

Isolated Single Umbilical Artery as a Risk Factor for Urinary Tract Infections in Childhood

Ambient air pollution and the risk of stillbirth: a population-based prospective birth cohort study in the coastal area of China

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