Impact of Kidney Transplantation on Humoral Immunity Against SARS-CoV-2: A Case Series From Belgium

Rapid Decline in Vaccine-induced Anti-SARS-CoV-2 Antibody Titers 3 Months After Kidney Transplantation: A Case Series From Belgium

“…Of the 4 patients who had received a single dose of vaccine, 2 had no detectable Ab on day 100 (despite one of them receiving a second dose in the meantime) and 2 had very low Ab titers (<1.5 U/mL). Similar to our previous report, 1 the Ab titer drop was not significantly different in patients inducted with thymoglobulin (n = 3) or basiliximab (n = 2) compared with the others (90% and 82% drop, respectively, versus 86% at day 100).…”

“…Ten patients had received their second dose of either the mRNA BNT162b2 (Pfizer-BioNTech, n = 8) or ChAdOx1 nCoV-19 vaccine (AstraZeneca, n = 2) at a mean time of 57 (range, 25–78) d before KT. 1 Four patients had received a single dose of vaccine (Pfizer-BioNTech n = 2, AstraZeneca n = 2) at a mean time of 29 (range, 13–50) d before KT, of which 2 patients received a second dose of the same vaccine 2 mo after KT. The mean age was 58 (range, 32–77) y; 57% were male.…”

“…W e and others previously reported persistent immunogenicity of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in the first month after kidney transplantation (KT) with, nevertheless, a significant drop in antibody (Ab) titer. [1][2][3] However, the mid-term impact of starting immunosuppression for KT on Ab titers has not been described yet.…”