Impact of labile plasma iron and iron chelation on the viability of cultured mononuclear cells from patients undergoing autologous hematopoietic stem cell transplantation

Naoum, Flávio Augusto; Espósito, Breno Pannia; Zotarelli-Filho, Idiberto José

doi:10.5045/br.2017.52.2.135

Cited by 1 publication

(1 citation statement)

References 11 publications

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“…In vitro tests on cardiac and endocrine cells have shown how after a prolonged and constant LPI exposition iron accumulates in organelles and increases ROS formation, affecting major cell functions such as permselectivity, electron transport activity, and viability. Again, iron chelation with Deferasirox was effective in reducing iron-induced cell damage and increasing viability of these cells 30…”

Section: Free Iron Toxicity During the Early Transplant Phase (Beforementioning

confidence: 96%

Guest Editor: Raffaella Origa IRON TOXICITY AND HEMOPOIETIC CELL TRANSPLANTATION: TIME TO CHANGE THE PARADIGM.

Pilo¹,

Angelucci

2019

Mediterr J Hematol Infect Dis

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The issue of iron overload in hemopoietic cell transplantation has been first discussed in the field of transplantation for thalassemia. Thalassemia major is characterized by ineffective erythropoiesis and hemolysis leading to anemia in the majority of patients. Patients require regular blood transfusion therefore they develop iron overload causing organ damage and hematopoietic cell transplantation (HCT) is a consolidated reliably curative option. In this category of patients an important issue for transplant outcome is the iron burden before transplant and in the long-life post-transplant. Nevertheless, today the concept of the impact of iron overload / toxicity on the outcome of HCT) has been extended to other diseases characterized by periods of variable duration of transfusion dependence Recent preclinical data has shown how increased production of reactive oxygen species (ROS) resulting under iron overload condition, could impair the stem cells clonality capacity, proliferation and maturation. Also, microenvironment cells could be affected through this mechanism. For this reason, iron overload is becoming an important issue also in the engraftment period post-transplantThe aim of this review is to update consolidated knowledge about the role of iron overload/iron toxicity in the HCT setting in non-malignant and in malignant diseases introducing the concept of exposition of free toxic iron forms and related cellular damage in the different stage of transplant.

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Section: Free Iron Toxicity During the Early Transplant Phase (Beforementioning

confidence: 96%

Guest Editor: Raffaella Origa IRON TOXICITY AND HEMOPOIETIC CELL TRANSPLANTATION: TIME TO CHANGE THE PARADIGM.

Pilo¹,

Angelucci

2019

Mediterr J Hematol Infect Dis

View full text Add to dashboard Cite

show abstract

Impact of labile plasma iron and iron chelation on the viability of cultured mononuclear cells from patients undergoing autologous hematopoietic stem cell transplantation

Cited by 1 publication

References 11 publications

Guest Editor: Raffaella Origa IRON TOXICITY AND HEMOPOIETIC CELL TRANSPLANTATION: TIME TO CHANGE THE PARADIGM.

Guest Editor: Raffaella Origa IRON TOXICITY AND HEMOPOIETIC CELL TRANSPLANTATION: TIME TO CHANGE THE PARADIGM.

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