Impact of latent tuberculosis infection on health and wellbeing: a systematic review and meta-analysis

Wong, Yen Jun; Noordin, Noorliza M.; Keshavjee, Salmaan; Lee, Shaun Wen Huey

doi:10.1183/16000617.0260-2020

Cited by 10 publications

(12 citation statements)

References 39 publications

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“…Treatment for severely drug-resistant TB can take up to two years and includes a cocktail of progressively unpleasant medicines with side effects ranging from nausea to irreversible hearing loss. When it comes to health-related quality of life (HRQoL) in persons with TB, it was discovered that it is much poorer than in those without TB [26].…”

Section: Public Health Impactmentioning

confidence: 99%

Tuberculosis amidst COVID-19 in Pakistan: a massive threat of overlapping crises for the fragile healthcare systems

et al. 2022

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Mycobacterium tuberculosis is the cause of tuberculosis (TB), a granulomatous illness that mostly affects the lungs. Pakistan is one of the eight nations that accounts for two-thirds of all new cases of developing TB. TB has long been an endemic disease in Pakistan. According to the World Health Organization (WHO) estimates, the nation has over 500 000 incident TB infections per year, with a rising number of drug-resistant cases. Recently, the coexistence of COVID-19 and TB in Pakistan has provided doctors with a problem. Fever or chills, cough, shortness of breath or difficulty breathing are all signs of COVID-19. After SARS-CoV-2 infection, cough might persist for weeks or months and it is frequently accompanied by persistent tiredness, cognitive impairment, dyspnoea or paina group of long-term consequences known as post-COVID syndrome or protracted COVID. Coughing with mucus or blood, and coughing that continues over 2 months are indications of TB. The same clinical presentation features make it difficult for healthcare personnel to effectively evaluate the illness and prevent the spread of these fatal diseases. Pakistan lacks the necessary healthcare resources to tackle two contagious diseases at the same time. To counteract the sudden increase in TB cases, appropriate management and effective policies must be implemented. Thus, in order to prevent the spread of these infectious diseases, it is critical to recognise and address the problems that the healthcare sector faces, as well as to create an atmosphere in which the healthcare sector can function at its full potential.

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Section: Public Health Impactmentioning

confidence: 99%

Tuberculosis amidst COVID-19 in Pakistan: a massive threat of overlapping crises for the fragile healthcare systems

et al. 2022

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“…(MVD2019.7.0.0) program was used for the validation of molecular docking. The docking scoring function MolDock score energy, E score is defined by (1), where E inter is the ligand-receptor interaction energy and E intra is the internal energy of the ligand. According to (2) equation, E inter is calculated.…”

Section: Molecular Docking Proceduresmentioning

confidence: 99%

“…Tuberculosis (TB) is one of the top ten causes of global mortality, with an estimated 1.5 million deaths due to TB in 2018, globally [1]. Mycobacterium TB (MTB) infection in humans does not usually lead to active disease.…”

Section: Introductionmentioning

confidence: 99%

Identification of Ethr Inhibitor Targeting Mycobacterium Tuberculosis: An Insight From Molecular Docking Study

Poleboyina

Pawar

2022

Asian J Pharm Clin Res

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Objective: Mycobacterium tuberculosis (MTB) is a pathogenic bacterium of the Mycobacteriaceae family that causes TB. EthR is a transcriptional regulator which is involved in the repression of the monooxygenase EthA which is responsible for the formation of the active metabolite of Eth. Inhibitors of the EthR DNA binding protein induce a conformational change in this repressor, thus preventing its binding to DNA operator, consequently resulting in increased transcription of EthA and bioactivation of Eth. Methods: In this study, we used first-line and second-line drugs and their analogues to validate the binding affinity of EthR DNA binding protein of MTB. Molegro Virtual Docker (MVD) is utilized for virtual screening and validation of MolDoc, Rerank, and hydrogen bond parameters of ETH, isoniazid (INH), clofazimine (CLF), and its modified derivatives to the EthR DNA binding protein of MTB. The modified molecules; ETH4, INZ2, CLF3, and CLF4 show more binding affinities than that of native compounds ETH, INH, and CLF to the EthR DNA binding protein of MTB. The top scoring compound was docked by auto dock vina in PyRx to get the best conformer pose for intermolecular interactions. Results: CLF4 had the best lowest MolDock score -176.29kcal/mol and H-bonding energy -6.89kcal/mol in the MVD virtual screening. The best conformer pose generated by PyRx was shown -7.1 binding affinity and ligand generated hydrogen bond interactions with THR130 and LYS68, respectively, which stabilized the ligand in the active site of EthR protein. Conclusion: We concluded that CLF4 has shown better inhibitory efficacy than other compounds towards EthR protein. However, these results need to be further substantiated through in vitro and in vivo experimental studies.

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“…The volunteers in this study were enrolled and subjected to the analysis using the IFN-γ release assay (QuantiFERON-TB Gold In-Tube (QFT), Qiagen, CA, USA) along with clinical, microbiological, and radiographical examinations. The criteria for enrollment were as follows: (1) patients with active TB (ATB group in this study) showed clinical and radiographical features of tuberculosis and were confirmed by sputum smear or culture. Moreover, they did not receive anti-TB treatment before sample selection.…”

Section: Subjects In This Study and Sample Collectionmentioning

confidence: 99%

Untargeted metabolomics of pulmonary tuberculosis patient serum reveals potential prognostic markers of both latent infection and outcome

Wang¹,

Zeng

et al. 2022

Front. Public Health

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Currently, there are no particularly effective biomarkers to distinguish between latent tuberculosis infection (LTBI) and active pulmonary tuberculosis (PTB) and evaluate the outcome of TB treatment. In this study, we have characterized the changes in the serum metabolic profiles caused by Mycobacterium tuberculosis (Mtb) infection and standard anti-TB treatment with isoniazid–rifampin–pyrazinamide–ethambutol (HRZE) using GC-MS and LC-MS/MS. Seven metabolites, including 3-oxopalmitic acid, akeboside ste, sulfolithocholic acid, 2-decylfuran (4,8,8-trimethyldecahydro-1,4-methanoazulen-9-yl)methanol, d-(+)-camphor, and 2-methylaminoadenosine, were identified to have significantly higher levels in LTBI and untreated PTB patients (T0) than those in uninfected healthy controls (Un). Among them, akeboside Ste and sulfolithocholic acid were significantly decreased in PTB patients with 2-month HRZE (T2) and cured PTB patients with 2-month HRZE followed by 4-month isoniazid-rifampin (HR) (T6). Receiver operator characteristic curve analysis revealed that the combined diagnostic model showed excellent performance for distinguishing LT from T0 and Un. By analyzing the biochemical and disease-related pathways, we observed that the differential metabolites in the serum of LTBI or TB patients, compared to healthy controls, were mainly involved in glutathione metabolism, ascorbate and aldarate metabolism, and porphyrin and chlorophyll metabolism. The metabolites with significant differences between the T0 group and the T6 group were mainly enriched in niacin and nicotinamide metabolism. Our study provided more detailed experimental data for developing laboratory standards for evaluating LTBI and cured PTB.

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Impact of latent tuberculosis infection on health and wellbeing: a systematic review and meta-analysis

Cited by 10 publications

References 39 publications

Tuberculosis amidst COVID-19 in Pakistan: a massive threat of overlapping crises for the fragile healthcare systems

Tuberculosis amidst COVID-19 in Pakistan: a massive threat of overlapping crises for the fragile healthcare systems

Identification of Ethr Inhibitor Targeting Mycobacterium Tuberculosis: An Insight From Molecular Docking Study

Untargeted metabolomics of pulmonary tuberculosis patient serum reveals potential prognostic markers of both latent infection and outcome

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