Impact of Left Ventricular Diastolic Dysfunction on Outcome of Catheter Ablation for Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy

Elevated Cardiac Enzymes in Hypertrophic Cardiomyopathy Patients With Heart Failure – A 20-Year Prospective Follow-up Study –

“…This is the manifestation of LV diastolic dysfunction in patients with HCM. 3, 29 Thus, the increase in left atrial dimension is not necessarily related to the deterioration of LV systolic dysfunction.…”

Catheter Ablation of Atrial Fibrillation in Chronic Heart Failure: A Contemporary Review

“…Fourteen studies were finally selected, with one study in particular including patients with tachycardiomyopathy (TCM), eight studies including patients with hypertrophic cardiomyopathy (HCM), and five studies including patients with valvular cardiomyopathy. [43][44][45][46][47][48][49][50][51][52][53][54][55][56] Observational studies. As detailed in Table 1, observational studies included 1,504 patients.…”

“…Concerning AF ablation outcome, eight observational studies have been conducted among HCM patients. [44][45][46][47][48][49][50][51] Consistently, all studies reported a very limited efficacy after a single ablation procedure. However, about half of the patients underwent repeated procedures, raising the efficacy up to 70% to 80%; in this respect, the prevalence of extensive LA or biatrial ablation, including linear lesions and CFAEs, was significantly higher as compared with more ''classical'' CHF patients ( Figure 1).…”

Perspectives on Catheter Ablation of Atrial Fibrillation

“…Although the safety of disopyramide in obstructive HCM patients was shown by an observational cohort study, 11 limited data are available on the safety of the use of antiarrhythmic drugs in patients with non-obstructive HCM. Antiarrhythmic drugs were given to 68% of patients in the study by Okamatsu et al 10 Presumably, the maintenance of sinus rhythm with the use of antiarrhythmic drugs was beneficial in terms of quality of life during the mid-term follow-up, but we must remember the potential risk of sudden cardiac death. In addition, the efficacy of antiarrhythmic drugs has become reduced over the years, 12 suggesting a limited effects of these drugs against the progression of AF.…”

“…9 That study suggested that the atrial substrate or triggers develop even if sinus rhythm is maintained for more than 1 year. In the study by Okamatsu et al, 10 patients were followed for less than 2 years, and an association between E/e' and late recurrence was not investigated. Another issue is the use of antiarrhythmic drugs.…”