Impact of Left Ventricular Hypertrophy on Survival in Chronic Obstructive Pulmonary Disease

Short, Philip; Anderson, William J.; Elder, Douglas; Struthers, Allan D.; Lipworth, Brian J.

doi:10.1007/s00408-015-9724-8

Cited by 10 publications

(6 citation statements)

References 28 publications

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“…Patients with COPD enrolled in a community COPD registry (the Tayside Allergy and Respiratory Disease Information System) 17 , 18 were recruited into this prospective longitudinal cohort study. Patients were included if they were older than 40 years, had an FEV 1 /forced vital capacity ratio of less than 70%, and had a clinical diagnosis of COPD.…”

Section: Methodsmentioning

confidence: 99%

Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease

Dicker

Crichton

Pumphrey

et al. 2018

Journal of Allergy and Clinical Immunology

238

187

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BackgroundNeutrophil extracellular traps (NETs) have been observed in the airway in patients with chronic obstructive pulmonary disease (COPD), but their clinical and pathophysiologic implications have not been defined.ObjectiveWe sought to determine whether NETs are associated with disease severity in patients with COPD and how they are associated with microbiota composition and airway neutrophil function.MethodsNET protein complexes (DNA-elastase and histone-elastase complexes), cell-free DNA, and neutrophil biomarkers were quantified in soluble sputum and serum from patients with COPD during periods of disease stability and during exacerbations and compared with clinical measures of disease severity and the sputum microbiome. Peripheral blood and airway neutrophil function were evaluated by means of flow cytometry ex vivo and experimentally after stimulation of NET formation.ResultsSputum NET complexes were associated with the severity of COPD evaluated by using the composite Global Initiative for Obstructive Lung Disease scale (P < .0001). This relationship was due to modest correlations between NET complexes and FEV1, symptoms evaluated by using the COPD assessment test, and higher levels of NET complexes in patients with frequent exacerbations (P = .002). Microbiota composition was heterogeneous, but there was a correlation between NET complexes and both microbiota diversity (P = .009) and dominance of Haemophilus species operational taxonomic units (P = .01). Ex vivo airway neutrophil phagocytosis of bacteria was reduced in patients with increased sputum NET complexes. Consistent results were observed regardless of the method of quantifying sputum NETs. Failure of phagocytosis could be induced experimentally by incubating healthy control neutrophils with soluble sputum from patients with COPD.ConclusionNET formation is increased in patients with severe COPD and associated with more frequent exacerbations and a loss of microbiota diversity.

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Section: Methodsmentioning

confidence: 99%

Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease

Dicker

Crichton

Pumphrey

et al. 2018

Journal of Allergy and Clinical Immunology

238

187

View full text Add to dashboard Cite

show abstract

“…Linkage included data from January 01, 2000 to October 31, 2014 including all community drug prescriptions, hospital stays, diagnoses, interventions, laboratory tests (including sputum microbiology), radiology and deaths. Patients were also included in the Tayside Respiratory Disease Information System (TARDIS) which provides annual data on spirometry, microbiology, respiratory symptoms and respiratory treatments, and has been used for multiple previous record linkage studies [12][13][14].…”

Section: Patient Population and Patient Data Linkagementioning

confidence: 99%

The impact of acute air pollution fluctuations on bronchiectasis pulmonary exacerbation: a case-crossover analysis

et al. 2018

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In bronchiectasis, exacerbations are believed to be triggered by infectious agents, but often no pathogen can be identified. We hypothesised that acute air pollution exposure may be associated with bronchiectasis exacerbations.We combined a case-crossover design with distributed lag models in an observational record linkage study. Patients were recruited from a specialist bronchiectasis clinic at Ninewells Hospital, Dundee, UK.We recruited 432 patients with clinically confirmed bronchiectasis, as diagnosed by high-resolution computed tomography. After excluding days with missing air pollution data, the final model for particles with a 50% cut-off aerodynamic diameter of 10 µm (PM) was based on 6741 exacerbations from 430 patients and for nitrogen dioxide (NO) it included 6248 exacerbations from 426 patients. For each 10 µg·m³ increase in PM and NO, the risk of having an exacerbation that same day increased significantly by 4.5% (95% CI 0.9-8.3) and 3.2% (95% CI 0.7-5.8) respectively. The overall (lag zero to four) increase in risk of exacerbation for a 10 μg·m increase in air pollutant concentration was 11.2% (95% CI 6.0-16.8) for PM and 4.7% (95% CI 0.1-9.5) for NO Subanalysis showed higher relative risks during spring (PM 1.198 (95% CI 1.102-1.303), NO 1.146 (95% CI 1.035-1.268)) and summer (PM 2.142 (95% CI 1.785-2.570), NO 1.352 (95% CI 1.140-1.602)) when outdoor air pollution exposure would be expected to be highest.In conclusion, acute air pollution fluctuations are associated with increased exacerbation risk in bronchiectasis.

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“…7 Considering the low number of strategies that have shown mortality benefit in COPD, targeting therapeutic strategies to address concurrent cardiovascular instability is of essence. 4,8 Current techniques to diagnose right ventricular (RV) dysfunction and PH in chronic lung diseases involve hemodynamic measurements that are both invasive and expensive, necessitating research on minimally invasive techniques for evaluation, including the use of cardiac biomarkers. 9,10 Biomarkers have been used extensively in the diagnosis of cardiac conditions, [11][12][13] but there are limited data on the role of cardiac biomarkers in AECOPD.…”

Section: Introductionmentioning

confidence: 99%

Role of B-Type Natriuretic Peptide in Predicting In-Hospital Outcomes in Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Preserved Left Ventricular Function: A 5-Year Retrospective Analysis

Vallabhajosyula

Haddad

Sundaragiri

et al. 2016

J Intensive Care Med

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Impact of Left Ventricular Hypertrophy on Survival in Chronic Obstructive Pulmonary Disease

Abstract: The presence of LVH, demonstrated by elevated left ventricular mass index is associated with a significantly increased risk of mortality in COPD patients. Therapeutic interventions are required to address this important modifiable risk factor in COPD patients.

Cited by 10 publications

References 28 publications

Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease

Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease

The impact of acute air pollution fluctuations on bronchiectasis pulmonary exacerbation: a case-crossover analysis

Role of B-Type Natriuretic Peptide in Predicting In-Hospital Outcomes in Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Preserved Left Ventricular Function: A 5-Year Retrospective Analysis

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