2021
DOI: 10.1007/s10409-021-01066-2
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Impact of leg bending in the patient-specific computational fluid dynamics of popliteal stenting

Abstract: Endovascular treatment of the femoro-popliteal artery has recently become a valuable therapeutic option for popliteal arterial aneurysms. However, its efficacy remains controversial due to the relatively high rate of complications, such as stent occlusion as result of intra-stent thrombosis. The elucidation of the interplay among vessel geometrical features, local hemodynamics, and leg bending seems crucial to understand onset and progression of popliteal intra-stent thrombosis. To this aim, patient-specific c… Show more

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Cited by 11 publications
(9 citation statements)
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“…Nevertheless, these findings are consistent with many previous fundamental studies showing that non-Newtonian simulations predict higher ESS ( 26 31 ). For instance, non-Newtonian flow decreases the area of low ESS in both straight and bent arterial segments, with the largest difference occurring in the straight rather than the bent segment ( 32 ). On the other hand, while blood viscosity affects the magnitude of ESS when the flow is disturbed, it does not affect the spatial and temporal distribution of the ESS ( 33 , 34 ).…”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, these findings are consistent with many previous fundamental studies showing that non-Newtonian simulations predict higher ESS ( 26 31 ). For instance, non-Newtonian flow decreases the area of low ESS in both straight and bent arterial segments, with the largest difference occurring in the straight rather than the bent segment ( 32 ). On the other hand, while blood viscosity affects the magnitude of ESS when the flow is disturbed, it does not affect the spatial and temporal distribution of the ESS ( 33 , 34 ).…”
Section: Discussionmentioning
confidence: 99%
“…As shown by recent clinical and numerical studies, the choice of treatment method has a significant effect on the mechanical and hemodynamic behaviors of FP arteries and an incorrect assessment by the clinician may generate adverse conditions that promote restenosis 4 , 11 , 12 . However, existing research is limited by the use of imaging methodologies 12 , 17 19 , which cannot accurately represent the arterial geometry, and, therefore, the results fail to provide conclusive evidence regarding the optimal treatment approach. As such, the main objective of this study was to develop a framework to build personalized models of FP arteries based on intra-arterial imaging.…”
Section: Discussionmentioning
confidence: 99%
“…Computational fluid dynamics (CFD) analyses provide an important framework to quantify the atherosclerosis-prone and -protective hemodynamic conditions in the artery, and can help predict whether the selected treatment will fail in the long-term. However, there are only a few numerical studies that investigated the flow behaviors in FP arteries following endovascular therapy 11 13 , 17 19 . Gökgöl et al used a custom-made algorithm to reconstruct the three-dimensional post-treatment arterial geometries of 20 patients from multiple 2D X-ray images 11 .…”
Section: Introductionmentioning
confidence: 99%
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“…Therefore, using an idealised model and accounting for pertinent boundary conditions in line with patient-specific data also clearly identifies essential components that affect the phenomena. Strong evidence is provided by Colombo et al, [36] and Ferrarini et al, [31] and others that patient-specific boundary conditions are more accurate in leg flexion investigations and directly guarantee the lack of irrational results. According to Colombo et al, [37], also discussed that due to limited resolution of CT and the metallic artefacts created by the stent in post-operative CT scans, viewing the stent struts and immediately rebuilding a 3D model of the stent is not possible.…”
Section: Geometry Constructionsmentioning
confidence: 98%