Impact of lifestyle modification on some components of metabolic syndrome in persons with severe mental disorders: A meta-analysis

Singh, Vinit Kumar; Karmani, Sneha; Malo, Palash Kumar; Virupaksha, H. G.; Muralidhar, D.; Venkatasubramanian, Ganesan; Muralidharan, Kesavan

doi:10.1016/j.schres.2018.06.066

Cited by 25 publications

(30 citation statements)

References 45 publications

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“…The effects of such health promotion interventions in patients with schizophrenia have been positive in some cases (Kimhy et al, 2015;Pajonk et al, 2010;Scheewe et al, 2013), although most have been limited (Gates et al, 2015). Weight-loss and exercise programs have been the most common interventions, and a meta-evaluation showed that several trials had positive outcomes (Singh et al, 2018), whereas others had mixed results (McGinty et al, 2016). A systematic review showed that nonpharmacological interventions led to less weight loss in patients with serious mental illness than in the general population.…”

Section: Comparison With Other Studiesmentioning

confidence: 99%

Outcome of a psychosocial health promotion intervention aimed at improving physical health and reducing alcohol use in patients with schizophrenia and psychotic disorders (MINT)

Westman

Eberhard

Gaughran

et al. 2019

Schizophrenia Research

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Background: Life expectancy is reduced by 19 years in men and 17 in women with psychosis in Sweden, largely due to cardiovascular disease.Aim: Assess whether a psychosocial health promotion intervention improves cardiometabolic risk factors, quality of life, and severity of illness in patients with psychotic disorders more than treatment as usual.Methods: A pragmatic intervention trial testing a manual-based multi-component health promotion intervention targeting patients with psychosis. The Swedish intervention was adapted from IMPaCT therapy, a health-promotion program based on motivational interviewing and cognitive behavioral therapy, designed to be incorporated into routine care.The intervention group consisted of 119 patients and a control group of 570 patients from specialized psychosis departments. Outcome variables were assessed 6 months before intervention during the run-in period, again at the start of intervention, and 12 months after the intervention began. The control group received treatment as usual.Results: The intervention had no significant effect on any of the outcome variables. However, BMI, waist circumference, systolic BP, heart rate, HbA1c, general health, and Clinical Global Impressions Scale score improved significantly during the run-in period before the start of the active intervention (observer effect). The multi-component design meant that treatment effects could only be calculated for the intervention as a whole.Conclusion: The results of the intervention are similar to those of the U.K. IMPaCT study, in which the modular health-promotion intervention had little effect on cardiovascular risk indicators. However, in the current study, the run-in period had a positive effect on cardiometabolic risk factors.

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Section: Comparison With Other Studiesmentioning

confidence: 99%

Outcome of a psychosocial health promotion intervention aimed at improving physical health and reducing alcohol use in patients with schizophrenia and psychotic disorders (MINT)

Westman

Eberhard

Gaughran

et al. 2019

Schizophrenia Research

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“…Several meta-analyses of lifestyle (diet and exercise) interventions for people with SMI have demonstrated improvements in metabolic risk factors, such as waist circumference, body mass index (BMI), fasting blood glucose, triglycerides, and blood pressure (6)(7)(8). A recent meta-review found l ifestyle inte rve ntions were comparable to pharmacotherapy for cardiometabolic risk reduction (9).…”

Section: Introductionmentioning

confidence: 99%

Feasibility and Acceptability of a Student-Led Lifestyle (Diet and Exercise) Intervention Within a Residential Rehabilitation Setting for People With Severe Mental Illness, GO HEART (Group Occupation, Health, Exercise And Rehabilitation Treatment)

et al. 2020

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Purpose: People with severe mental illness (SMI) experience poor physical health and premature mortality, contributed significantly by modifiable lifestyle risk factors such as poor nutrition, low cardiorespiratory fitness, and physical inactivity. Lifestyle interventions can reduce cardiometabolic risk and confer a range of other positive mental and physical health benefits. We assessed the feasibility, acceptability, safety, and preliminary effectiveness of a lifestyle (combined dietary and exercise) intervention lead by senior exercise and dietetics students in a residential mental health rehabilitation setting. Design: Single arm, prospective study evaluating outcomes pre and post a 10-week dietary and exercise intervention. Method: People with SMI from three residential rehabilitation units participated in a mixed aerobic and resistance training exercise intervention three times per week that was combined with a dietary intervention (six individual and group sessions). Primary outcome considerations were feasibility (recruitment, retention, and participation rates), acceptability, and adverse events. Secondary outcomes were preliminary effectiveness; (functional exercise capacity, volume of exercise, and metabolic markers), psychiatric symptoms, quality of life, and attitudes to exercise. Results: Forty-two participants were recruited (92% primary diagnosis of schizophrenia). Intervention feasibility was supported by high levels of recruitment (68%), retention (77%),

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“…Although metabolic abnormalities may be already present in drug naïve SMI patients, reflecting disease-specific mechanisms, it appears that the development of these abnormalities is also attributable to a cumulative long-term effect of unhealthy lifestyle choices and psychotropic medication use, independent of psychiatric disease ( 123 – 125 ). In general, metabolic abnormalities are most common with antipsychotics.…”

Section: Discussionmentioning

confidence: 99%

Impact of Psychotropic Medication Effects on Obesity and the Metabolic Syndrome in People With Serious Mental Illness

et al. 2020

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People with serious mental illness (SMI), including schizophrenia, bipolar disorder, and major depressive disorder, have a higher mortality rate and shortened life expectancy. This is mainly attributable to physical diseases, particularly cardiovascular diseases (CVDs). Important risk factors for CVDs are obesity and other metabolic abnormalities, which are especially prevalent in people with SMI. Several factors contribute to this increased risk, including unhealthy lifestyles. Psychotropic medication independently further increases this risk. In this review we want to examine the relationship between obesity and other components of the metabolic syndrome and psychotropic medication in people with SMI.

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Impact of lifestyle modification on some components of metabolic syndrome in persons with severe mental disorders: A meta-analysis

Cited by 25 publications

References 45 publications

Outcome of a psychosocial health promotion intervention aimed at improving physical health and reducing alcohol use in patients with schizophrenia and psychotic disorders (MINT)

Outcome of a psychosocial health promotion intervention aimed at improving physical health and reducing alcohol use in patients with schizophrenia and psychotic disorders (MINT)

Feasibility and Acceptability of a Student-Led Lifestyle (Diet and Exercise) Intervention Within a Residential Rehabilitation Setting for People With Severe Mental Illness, GO HEART (Group Occupation, Health, Exercise And Rehabilitation Treatment)

Impact of Psychotropic Medication Effects on Obesity and the Metabolic Syndrome in People With Serious Mental Illness

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