Impact of liraglutide on microcirculation in experimental diabetic cardiomyopathy

Soliman, Nehad Gamal Abdelrazik; Abdel-Hamid, Ahmed A.M.; El-Hawwary, Amany A.; Ellakkany, Amany S

doi:10.1016/j.acthis.2020.151533

Cited by 5 publications

(4 citation statements)

References 48 publications

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“… Group 3: Normal saline was administered to nondiabetic rats for the initial 3 weeks before they were injected with 150 μg/kg liraglutide subcutaneously (SC) twice daily for the subsequent 3 weeks. The dose was chosen based on previous studies demonstrating its cardioprotective effects in diabetic rats [ 71 ]. Notably, the volume of liraglutide stock solution (6 mg/mL) injected was dependent on each rat’s weight.…”

Section: Methodsmentioning

confidence: 99%

“…Notably, the volume of liraglutide stock solution (6 mg/mL) injected was dependent on each rat’s weight. Group 4: Normal saline was administered to diabetic rats for the initial 3 weeks, and they were subsequently injected with 150 μg/kg liraglutide SC twice daily [ 71 ] for the remaining 3 weeks. …”

Section: Methodsmentioning

confidence: 99%

“…Group 4: Normal saline was administered to diabetic rats for the initial 3 weeks, and they were subsequently injected with 150 μg/kg liraglutide SC twice daily [ 71 ] for the remaining 3 weeks.…”

Section: Methodsmentioning

confidence: 99%

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Liraglutide Attenuates Diabetic Cardiomyopathy via the ILK/PI3K/AKT/PTEN Signaling Pathway in Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus

Alobaid,

Alshahrani,

Alonazi

et al. 2024

Pharmaceuticals

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One of the possible candidates for the treatment of diabetic cardiomyopathy is liraglutide, a glucagon-like peptide-1 receptor (GLP1R) agonist. In this study, the impacts of liraglutide on the integrin-linked kinase (ILK)-related PI3K/AKT axis in rats with type 2 diabetes induced via streptozotocin were examined. Twenty-four Wistar albino rats were distributed in four different groups, and a high-fat diet and streptozotocin were used to induce type 2 in two groups. Rats in the untreated control groups were administered 0.9% NaCl solution over a 6-week period, and those in the treatment groups were administered 0.9% NaCl for 3 weeks, followed by subcutaneous injection of liraglutide (150 μg/kg) for an additional 3 weeks. In the liraglutide-treated diabetic group, the heart-to-body weight ratio was significantly reduced, levels of cardiac biomarkers, troponin I and creatine-kinase-MB, were improved; activities of antioxidant enzymes, glutathione peroxidase and superoxide dismutase, were increased; and levels of malondialdehyde were decreased. Western blotting and immunohistochemical studies revealed increased levels of ILK, P-PI3K, P-AKT, and BCL2, as well as those of caspase 3, BAX, and P-PTEN, indicating mitigation of cardiomyocyte apoptosis. Our results show that liraglutide, by targeting GLP1Rs, enhances the expression of proteins in the ILK/PI3K/AKT/PTEN pathway and thereby exerts its cardioprotective effects in rats with DCM.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Liraglutide Attenuates Diabetic Cardiomyopathy via the ILK/PI3K/AKT/PTEN Signaling Pathway in Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus

Alobaid,

Alshahrani,

Alonazi

et al. 2024

Pharmaceuticals

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“…The coronary blood flow reserve of diabetic patients is significantly less than healthy people 70 . It has also been shown in animal experiments that the occurrence of diabetes leads to a decrease of arterioles in the heart 71 . The reason for this phenomenon may be partly related to the increased secretion of endothelin‐1 (ET‐1) which is thought to induce potent vasoconstriction through increasing the expression of protein kinase C (PKC).…”

Section: Melatonin Improves Endothelial Dysfunction and Microcirculat...mentioning

confidence: 99%

New insights into the role of melatonin in diabetic cardiomyopathy

Huang

Luo

Zhong

et al. 2022

Pharmacology Res & Perspec

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Thirty years ago, the prevalence of diabetic patients was only onefourth the current prevalence. In fact, the current number of diabetic patients has soared to 1 diabetic patient in every 11 people globally. 1 Moreover, diabetes has become the ninth leading cause of death worldwide. According to statistics from the World Health Organization, as of 2000, the number of diabetes patients worldwide had exceeded 170 million, and it is still increasing at an extremely fast rate. It is predicted that the number of diabetic-related deaths will double between 2000 and 2030. 2 Among diabetic patients, type 2 diabetes mellitus (T2DM) is most common, accounting for approximately 90% of adult patients with diabetes. Unlike type 1 diabetes mellitus (T1DM), which is an autoimmune disease, the

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Application of virtual touch tissue imaging quantification in diagnosis of supraspinatus tendon injury

Deng

Lü

et al. 2021

XST

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OBJECTIVE: To explore the value of virtual touch imaging and quantification (VTIQ) shear wave elastography (SWE) in diagnosis of supraspinatus tendon tear. METHODS: Eighty patients with unilateral supraspinatus tendon tear underwent shoulder arthroscopy were prospective studied. Tendinopathy, partial-thickness tear or full-thickness tear of supraspinatus tendon were diagnosed according 2D ultrasound examination. Sensitivity, specificity and accuracy of ultrasonic diagnosis of supraspinatus tendon tear were calculated by arthroscopy as the gold standard. VTIQ was applied to measure the shear-wave velocity (SWV) of both normal and affected supraspinatus tendon. The differences of SWV in three types of supraspinatus tendon tear and receiver operating characteristic (ROC) curves were analyzed. RESULTS: Among 80 patients, there were 20 tendinopathy, 31 partial tears and 29 full-thickness tears diagnosed by shoulder arthroscopy. Sensitivity, specificity and accuracy of 2D ultrasound in diagnosis of tendinopathy, partial tear and full-thickness tear groups were 78%, 90%and 83%; 71%, 86%and 73%; 86%, 88%and 88%, respectively. SWV of 80 supraspinatus tendon tears was 4.59±1.00 m/s, which was lower than that of normal supraspinatus tendon (4.59±1.00 m/s vs. 6.68±1.05 m/s, P < 0.01). SWV of supraspinatus tendon in tendinopathy, partial tear and full-thickness tear groups respectively were 5.66±0.97, 4.66±1.00, and 3.78±0.55 m/s, all lower than that of the contralateral normal supraspinatus tendon (all P < 0.05). In addition, the analysis of variance and pairwise comparison showed that SWV of supraspinatus tendon among three different degree of injury was statistically significant (all P < 0.001). The cutoff thresholds of SWV was 4.83 m/s to identify tendinopathy tear from partial tear and was 4.08 m/s to identify full-thickness tear from partial-thickness tear. CONCLUSION: VTIQ SWE with SWV might identify degree of supraspinatus tendon tear and improve the value of ultrasonography, which should be further evaluated in large multicenter studies.

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Impact of liraglutide on microcirculation in experimental diabetic cardiomyopathy

Cited by 5 publications

References 48 publications

Liraglutide Attenuates Diabetic Cardiomyopathy via the ILK/PI3K/AKT/PTEN Signaling Pathway in Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus

Liraglutide Attenuates Diabetic Cardiomyopathy via the ILK/PI3K/AKT/PTEN Signaling Pathway in Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus

New insights into the role of melatonin in diabetic cardiomyopathy

Application of virtual touch tissue imaging quantification in diagnosis of supraspinatus tendon injury

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