“…Yet, whether CD53 mechanistically participates in the adaptive metabolic effects, which we previously demonstrated in GLUT8-deficient mice ( e.g. , protection from NAFLD and insulin resistance ( 32 , 33 , 38 , 44 , 53 , 70 , 71 , 72 )), remains to be fully determined. Nevertheless, we introduced a novel scaffolded trehalose polymer, which is a unique composition of matter, and water-soluble compound that induces hepatocyte fasting–like signaling responses, and inhibits CD53 expression in unperturbed, fructose-, and FA-treated hepatocytes to an equal or greater extent than trehalose.…”