Impact of local endothelial shear stress on neointima and plaque following stent implantation in patients with ST-elevation myocardial infarction: A subgroup-analysis of the COMFORTABLE AMI–IBIS 4 trial

Bourantas, Christos V.; Räber, Lorenz; Zaugg, Serge; Sakellarios, Antonis I.; Taniwaki, Masanori; Heg, Dik; Moschovitis, Aris; Radu, Maria; Papafaklis, Michail I.; Kalatzis, Fanis G.; Naka, Katerina K.; Fotiadis, Dimitrios I.; Michalis, Lampros K.; Serruys, Patrick W.; Garcia, Hector M.; Windecker, Stephan

doi:10.1016/j.ijcard.2015.03.160

Cited by 32 publications

(14 citation statements)

References 25 publications

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“…With the exception of the articles published by Suzuki et al [21] and Papafaklis et al [22], where the WSS was not associated with NIH after implantation of SES, further data on straight vessels confirmed that the WSS determines neointimal formation in DESs [23][24][25].…”

Section: Des Studiesmentioning

confidence: 84%

Wall shear stress in the development of in-stent restenosis revisited. A critical review of clinical data on shear stress after intracoronary stent implantation

et al. 2016

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Section: Des Studiesmentioning

confidence: 84%

Wall shear stress in the development of in-stent restenosis revisited. A critical review of clinical data on shear stress after intracoronary stent implantation

et al. 2016

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“…High ESS can stimulate the production of metalloproteinases by macrophages, which could contribute to expansive remodeling [27,28]. On the contrary, in lesions implanted with bare metal stent or DES, ESS did not impact on vessel remodeling in IBIS-4 [29]. It is of note that BRS had p-value<0.10 in univariate analysis; however, in the multivariate model, it was not retained while ESS was with a significant p-value.…”

Section: Predictors Of Vessel Remodeling 421 Endothelial Shear Stress Post-proceduresmentioning

confidence: 90%

Endothelial shear stress and vascular remodeling in bioresorbable scaffold and metallic stent

et al. 2020

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Background and aims: The impact of endothelial shear stress (ESS) on vessel remodeling in vessels implanted with bioresorbable scaffold (BRS) as compared to metallic drug-eluting stent (DES) remains elusive. The aim of this study was to determine whether the relationship between ESS and remodeling patterns differs in BRS from those seen in metallic DES at 3-year follow-up. Methods: In the ABSORB II randomized trial, lesions were investigated by serial coronary angiography and intravascular ultrasound (IVUS). Three-dimensional reconstructions of coronary arteries post-procedure and at 3 years were performed. ESS was quantified using non-Newtonian steady flow simulation. IVUS cross-sections in device segment were matched using identical landmarks. Results: Paired ESS calculations post-procedure and at 3 years were feasible in 57 lesions in 56 patients. Postprocedure, median ESS at frame level was higher in BRS than in DES, with marginal statistical significance (0.97 ± 0.48 vs. 0.75 ± 0.39 Pa, p = 0.063). In the BRS arm, vessel area and lumen area showed larger increases

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“…Previous studies stated that low WSS was associated with increased neointimal hyperplasia (NIH), but in the present state of the research it is not clarifi ed that when the compensatory NIH re-establishes the WSS to physiological level and when it overshoots into the clinical restenosis. The NIH was used as a surrogate end point and not a clinical one [6][7][8][9][10][11] in most of the publications raising the question whether the detected NIH is a part of the healing process after stent implantation or a predictor of a later restenosis.…”

Section: Discussionmentioning

confidence: 99%

High shear stress on the background of clinical restenosis at the site of step-down phenomenon after drug eluting stent implantation

Jenei¹,

Závodszky

Paál

et al. 2016

Cor Vasa

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Please cite this article as: C. Jenei, et al., High shear stress on the background of clinical restenosis at the site of step-down phenomenon after drug eluting stent implantation, Cor et Vasa 58 (2016) e518-e521 as published in the online version of Cor et Vasa available at SOUHRNU nemocného s restenózou zjištěnou šest měsíců po implantaci lékového stentu (drug-eluting stent, DES) byla ve snaze zhodnotit vliv zmenšování průměru stentu směrem k jeho distálnímu konci (step-down) na smykové napětí ve stěně tepny (wall shear stress, WSS) provedena retrospektivní remodelace 3D koronarografi ckou rekonstrukcí a průběhu intrakoronárního tlaku během srdečního cyklu. Kinetika WSS se vypočítávala v průběhu celého cyklu podél rekonstruované tepny metodou analýzy dynamiky tekutin. Na rozdíl od starších zpráv byla největší amplituda a průměrná hodnota WSS tepny zjištěna v místě zmenšení průměru (step-down), kde později došlo ke vzniku restenózy. ABSTRACT A retrospective modeling was performed in a case with restenosis after 6 months of a DES implantation to investigate the effect of the step-down at the distal edge of the stent on the wall shear stress (WSS) using 3D coronary angiography reconstruction and the intracoronary pressure traces during a cardiac cycle. The kinetics of the WSS was calculated through the cardiac cycle along the reconstructed vessel by fl uid dynamic analysis. Contrary to the previous reports the greatest amplitude and average of the arterial WSS was detected where the restenosis developed later at the site of the step-down.

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Impact of local endothelial shear stress on neointima and plaque following stent implantation in patients with ST-elevation myocardial infarction: A subgroup-analysis of the COMFORTABLE AMI–IBIS 4 trial

Cited by 32 publications

References 25 publications

Wall shear stress in the development of in-stent restenosis revisited. A critical review of clinical data on shear stress after intracoronary stent implantation

Wall shear stress in the development of in-stent restenosis revisited. A critical review of clinical data on shear stress after intracoronary stent implantation

Endothelial shear stress and vascular remodeling in bioresorbable scaffold and metallic stent

High shear stress on the background of clinical restenosis at the site of step-down phenomenon after drug eluting stent implantation

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