Impact of location on outcome in children with low‐grade oligodendroglioma

Peters, Ove A.; Gnekow, Astrid; Rating, D.; Wolff, Johannes

doi:10.1002/pbc.20111

Cited by 41 publications

(36 citation statements)

References 47 publications

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“…Note that although some clinical studies with children and teenagers surgically treated for oligodendroglial tumors have been published during recent years, they did not report on very long-term prognosis. 1,2,7,[14][15][16][19][20][21] Our clinical results clearly indicate that long-term survival is more common in children and teenagers than in adults with such tumors.…”

mentioning

confidence: 82%

Neurosurgical treatment of oligodendroglial tumors in children and adolescents: a single-institution series of 35 consecutive patients

Lundar

Due-Tønnessen²,

Egge³

et al. 2013

PED

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Object The object of this study was to delineate long-term results of the surgical treatment of pediatric CNS tumors classified as oligodendroglioma (OD) or oligoastrocytoma (OA) WHO Grade II or III. Methods A cohort of 45 consecutive patients 19 years or younger who had undergone primary resection of CNS tumors originally described as oligodendroglial during the years 1970–2009 at a single institution were reviewed in this retrospective study of surgical morbidity, mortality, and academic achievement and/or work participation. Gross motor function and activities of daily living were scored using the Barthel Index (BI). Results Patient records for 35 consecutive children and adolescents who had undergone resection for an OA (17 patients) or OD (18 patients) were included in this study. Of the 35 patients, 12 were in the 1st decade of life at the first surgery, whereas 23 were in the 2nd decade. The male/female ratio was 1.19 (19/16). No patient was lost to follow-up. The tumor was localized to the supratentorial compartment in 33 patients, the posterior fossa in 1 patient, and the cervical medulla in 1 patient. Twenty-four tumors were considered to be WHO Grade II, and 11 were classified as WHO Grade III. Among these latter lesions were 2 tumors initially classified as WHO Grade II and later reclassified as WHO Grade III following repeat surgery. Fifty-four tumor resections were performed. Two patients underwent repeat tumor resection within 5 days of the initial procedure, after MRI confirmed residual tumor. Another 10 patients underwent a second resection because of clinical deterioration and progressive disease at time points ranging from 1 month to 10 years after the initial operation. Six patients underwent a third resection, and 1 patient underwent a fourth excision following tumor dissemination to the spinal canal. Sixteen (46%) of the 35 children received adjuvant therapy: 7, fractionated radiotherapy; 4, chemotherapy; and 5, both fractionated radiotherapy and chemotherapy. One patient with primary supratentorial disease experienced clinically malignant development with widespread intraspinal dissemination 9 years after initial treatment. Only 2 patients needed treatment for persistent hydrocephalus. In this series there was no surgical mortality, which was defined as death within 30 days of resection. However, 12 patients in the study, with follow-up times from 1 month to 33 years, died. Twenty-three patients, with follow-up times from 4 to 31 years, remained alive. Among these survivors, the BI was 100 (normal) in 22 patients and 80 in 1 patient. Nineteen patients had full- or part-time work or were in normal school programs. Conclusions Pediatric oligodendroglial tumors are mainly localized to the supratentorial compartment and more often occur in the 2nd decade of life rather than the 1st. Two-thirds of the patients remained alive after follow-ups from 4 to 31 years. Twelve children succumbed to their disease, 9 of them within 3 years of resection despite combined treatment with radio- and chemotherapy. Three of them remained alive from 9 to 33 years after primary resection. Among the 23 survivors, a stable, very long-term result was attainable in at least 20. Five-, 10-, 20-, and 30-year overall survival in patients with Grade II tumors was 92%, 92%, 92%, and 88%, respectively.

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confidence: 82%

Neurosurgical treatment of oligodendroglial tumors in children and adolescents: a single-institution series of 35 consecutive patients

Lundar

Due-Tønnessen²,

Egge³

et al. 2013

PED

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“…Of these publications, 20 were case series (Table). 1,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Histologically, the vast majority (70%-90%) of reported thalamic tumors are classified as astrocytoma. However, this literature is limited and difficult to interpret regarding histologic subtypes in children, as many studies combine age groups, are confined to more specific entities (eg, pilocytic astrocytoma (PA) or ''high-grade astrocytoma''), group biologically distinct entities (eg, PA and low-grade diffuse astrocytoma [DA] as ''low-grade astrocytoma''), or are single case reports.…”

Section: Epidemiologymentioning

confidence: 99%

“…Interestingly, a number of authors have singled out thalamic or ''central'' oligodendroglioma as being biologically distinct both from diffuse thalamic astrocytomas of a comparable grade and from peripheral (hemispheric) pediatric oligodendrogliomas of a comparable grade. 6,7,11,16,26,39 Thalamic oligodendrogliomas are often anaplastic at biopsy/ resection and relentlessly progress (14% 3-year survival in one series) despite extent of resection or chemotherapy and radiation in a manner comparable with thalamic glioblastoma. 16 Surprisingly, low-grade (WHO grade II) thalamic oligodendrogliomas have a similarly dismal prognosis.…”

Section: Who Classification Of Tumors Of the Central Nervous Systemmentioning

confidence: 99%

“…Although samples are small, various reports indicate overall survival times range from 12 to 24 months. 11,26,39 Difficulty of resection clearly plays a role in these statistics; however, the thalamic location may also impart a distinct biology to these tumors. As with pediatric oligodendrogliomas in general, the thalamic variant is not IDH1/2 mutated or 1p/19q codeleted.…”

Section: Who Classification Of Tumors Of the Central Nervous Systemmentioning

confidence: 99%

“…But with improved surgical techniques, total or partial resection is now more frequently performed, particularly for noninfiltrating, low-grade tumors. [1][2][3][4][5][6][7][8][9][10][11][12][13] Additionally, children with even incompletely resected low-grade thalamic gliomas can have a 5-year overall survival rate greater than 80% with adjuvant chemotherapy and radiation. 13,14 Therefore, histologic verification is now thought to be critical for planning treatment, and, as a result, biopsy and total/subtotal resections are much more common today than in the past.…”

mentioning

confidence: 99%

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Pediatric Thalamic Gliomas: An Updated Review

Gupta¹,

Shaller

McFadden³

2017

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Neoplasms originating in the thalamus are rare overall (1% of all brain tumors); however, they comprise approximately 5% of pediatric intracranial tumors and approach 15% of all malignant pediatric intracranial tumors in some series.Objective.-To update readers about the current understanding of the diverse histology, biology, and behavior of pediatric thalamic tumors. Histologic verification is now thought to be critical for planning treatment, and, as a result, biopsy and total/subtotal resections are much more common today than in the past.Data Sources.-A PubMed search using the keywords ''pediatric þ thalamic þ glioma'' yielded 45 publications with a total of 445 cases of thalamic gliomas in patients less than 18 years of age. We found only 9 substantial institutional series tabulating all encountered thalamic histologic types in children. This survey confirmed a high proportion of astrocytomas, 81% (214 of 265), of which approximately two-thirds were diffuse astrocytomas (146 of 214) and one-third were pilocytic astrocytomas (68 of 214). Of the diffuse astrocytomas, 34% (49 of 146) were low grade (World Health Organization grade II) and 55% (81 of 146) were high grade (World Health Organization grade III or IV), making the latter subgroup the largest single category of all pediatric thalamic tumors. Oligodendrogliomas and ependymomas (mostly anaplastic in both cases) comprised 10% and 3% of all pediatric thalamic tumors, respectively.Conclusions.-Tissue diagnosis is now thought crucial for prognostication and treatment, particularly as more potentially therapeutic molecular targets are discovered. Secure diagnosis allows identification of tumors for which resection is more feasible and beneficial.

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Impact of chemotherapy on disseminated low‐grade glioma in children and adolescents: Report from the HIT‐LGG 1996 trial

Hornstein

Kortmann²,

Pietsch

et al. 2011

Pediatric Blood & Cancer

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Impact of location on outcome in children with low‐grade oligodendroglioma

Abstract: The outcome of children with centrally located low-grade oligodendroglioma is particularly poor, while tumors of the cerebral hemispheres and cerebellum carry an excellent prognosis, even with minor tumor resection.

Cited by 41 publications

References 47 publications

Neurosurgical treatment of oligodendroglial tumors in children and adolescents: a single-institution series of 35 consecutive patients

Neurosurgical treatment of oligodendroglial tumors in children and adolescents: a single-institution series of 35 consecutive patients

Pediatric Thalamic Gliomas: An Updated Review

Impact of chemotherapy on disseminated low‐grade glioma in children and adolescents: Report from the HIT‐LGG 1996 trial

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