Impact of long-term parental exposure to Tamiflu metabolites on the development medaka offspring (Oryzias latipes)

Chen, Wei Yu; Wu, Yen-Ting; Lin, Han‐Wei; Ieong, Meng-Ian; Lee, Bing-Heng

doi:10.1016/j.envpol.2020.114146

Cited by 15 publications

(9 citation statements)

References 36 publications

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“…No photolytic TPs were observed due to the lower removal proportion (8.8%, Fig. 3 b ) in this study with reference to literature ( Chen et al, 2020a , Omar et al, 2017 ).…”

Section: Quantitative Analysis With Eps-subtypes and Secondary Structure Proteinssupporting

confidence: 72%

Unravelling multiple removal pathways of oseltamivir in wastewater by microalgae through experimentation and computation

Zeeshan

Qiu

et al. 2022

Journal of Hazardous Materials

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Increased worldwide consumption of antiviral drugs (AVDs) amid COVID-19 has induced enormous burdens to the existing wastewater treatment systems. Microalgae-based bioremediation is a competitive alternative technology due to its simultaneous nutrient recovery and sustainable biomass production. However, knowledge about the fate, distribution, and interaction of AVDs with microalgae is yet to be determined. In this study, a concentration-determined influence of AVD oseltamivir (OT) was observed on the biochemical pathway of Chlorella sorkiniana (C.S-N1) in synthetic municipal wastewater. The results showed that high OT concentration inhibited the biomass growth through increased oxidative stress, and restrained photosynthesis. Nevertheless, complete OT removal was achieved at its optimized concentration of 10 mg/L by various biotic (82%) and abiotic processes (18.0%). The chemical alterations in three subtypes of extracellular polymeric substances (EPS) were primarily investigated by electrostatic (OT +8.22 mV vs. C.S-N1 -18.31 mV) and hydrophobic interactions between EPS-OT complexes supported by secondary structure protein analysis. Besides, six biodegradation-catalyzed transformation products were identified by quadrupole-time-of-flight mass spectrometer and by density functional theory. Moreover, all the TPs exhibited log Kow ≤ 5 and bioconcentration factor values of < 5000 L/kg, meeting the practical demands of environmental sustainability. This study broadens our understanding of microalgal bioadsorption and biodegradation, promoting microalgae bioremediation for nutrient recovery and AVDs removal.

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“…No photolytic TPs were observed due to the lower removal proportion (8.8%, Fig. 3 b ) in this study with reference to literature ( Chen et al, 2020a , Omar et al, 2017 ).…”

Section: Quantitative Analysis With Eps-subtypes and Secondary Structure Proteinssupporting

confidence: 72%

Unravelling multiple removal pathways of oseltamivir in wastewater by microalgae through experimentation and computation

Zeeshan

Qiu

et al. 2022

Journal of Hazardous Materials

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“…Fish exposed to tramadol exhibited weight loss, abnormal behaviour and mitochondrial structural changes, possibly mediated by its by-products Oxazepam [temazepam] (Huerta et al 2016 ) Pimephales promelas 0.8, 4.7 and 30.6 µg/L 28 days Behaviour and bioaccumulation Brain was the tissue with higher accumulation rates; behavioural effects detected in the novel tank diving test were observed in fish exposed to 4.7 μg/L Oxazepam [temazepam] (Fahlman et al 2021 ) Perca fluviatilis 15 μg/L 14 days anti-predator behaviour Stimulation of anti-predator behaviour (decreased activity, decreased distance to conspecifics and increased littoral habitat use) Oxcarbamazepine [carbamazepine] (Desbiolles et al 2020 ) Lemna minor 27 ng/L 17 days Phytometabolites Increase in nitrogen compounds. Chlorophyll index was higher in relation to control Hydra circumcincta 900 ng/L 14 days Reproduction, morphological changes and oxidative stress biomarkers Single exposure impacted the total antioxidant capacity Acridine 9-carboxylic acid [oxcarbazepine] (Desbiolles et al 2020 ) Lemna minor 27 ng/L 17 days Phytometabolites Alterations of the nitrogen balance and chlorophyll indices at environmental concentrations Oseltamivir carboxylate [osetalmivir] (Chen et al 2020 ) Oryzias latipes 0, 0.06, 0.3, 90 and 300 µg/L 14, 21 and 56 days median survival, growth, reproduction and hatchability Long-term parental exposure to by-products affected the embryonic development of fish hatchability at 300 µg/L and development 90 µg/L Oseltamivir ethyl ester [osetalmivir] (Chen et al 2020 ) …”

Section: Risks Of Pharmaceutical and Pesticide Transformation Productsmentioning

confidence: 99%

Occurrence of Pharmaceutical and Pesticide Transformation Products in Freshwater: Update on Environmental Levels, Toxicological Information and Future Challenges

Rodrigues

Oliva-Teles

Guimarães

et al. 2022

Reviews Env.Contamination (formerly:Residue Reviews)

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Pharmaceuticals and pesticides are recognized micropollutants in freshwater systems. Their ever-increasing frequency of detection, levels found and little information available about their effects on non-target organisms, make them emerging contaminants. However, parental compounds are not the only substances of concern. Their metabolites and degradation products, hereby referred to as transformation products, are increasingly detected in freshwater samples and wastewater effluents. In the past years, a wealth of publications provided concentration levels detected in freshwater and some toxicological data, which required critical systematization. This review identified concentrations for 190 transformation products (92 from pesticides and 98 from pharmaceuticals) in water bodies and wastewater effluents. A concentration heatmap was produced to easily spot the substances found at higher levels and plan future research. The very limited available toxicological data link exposure to transformation products to adverse outcomes in humans (genotoxicity and alteration in detoxification processes) and aquatic species (mostly related to apical endpoints). Overall, environmental levels of these transformation products may pose a severe threat to aquatic organisms and need to be further investigated in sound experimental designs, testing for the effects of the single substances as well as of their mixtures. Such toxicological information is highly needed to improve both water treatment technologies and monitoring programmes. Supplementary Information The online version contains supplementary material available at 10.1007/s44169-022-00014-w.

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“…As a result, the use of remdesivir has increased rapidly in recent years, which has also aroused great concern about the environmental impact of remdesivir. As was the case with the Tamiflu drug during the H1N1 outbreak, when its consumption increased significantly, the environmental concentration of the remdesivir drug and its metabolites subsequently increased, and the same ecological risk could occur with the remdesivir drug now under discussion (Chen et al, 2014, 2020).…”

Section: Introductionmentioning

confidence: 99%

The mechanism and effects of remdesivir‐induced developmental toxicity in zebrafish: Blood flow dysfunction and behavioral alterations

Zhang

Song

et al. 2022

J of Applied Toxicology

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The antiviral drug remdesivir has been used to treat the growing number of coronavirus disease 2019 (COVID-19) patients. However, the drug is mainly excreted through urine and feces and introduced into the environment to affect non-target organisms, including fish, which has raised concerns about potential ecotoxicological effects on aquatic organisms. Moreover, studies on the ecological impacts of remdesivir on aquatic environments have not been reported. Here, we aimed to explore the toxicological impacts of microinjection of remdesivir on zebrafish early embryonic development and larvae and the associated mechanism. We found that 100 μM remdesivir

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Impact of long-term parental exposure to Tamiflu metabolites on the development medaka offspring (Oryzias latipes)

Cited by 15 publications

References 36 publications

Unravelling multiple removal pathways of oseltamivir in wastewater by microalgae through experimentation and computation

Unravelling multiple removal pathways of oseltamivir in wastewater by microalgae through experimentation and computation

Occurrence of Pharmaceutical and Pesticide Transformation Products in Freshwater: Update on Environmental Levels, Toxicological Information and Future Challenges

The mechanism and effects of remdesivir‐induced developmental toxicity in zebrafish: Blood flow dysfunction and behavioral alterations

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