Impact of Long-Term Support with Berlin Heart EXCOR® in Pediatric Patients with Severe Heart Failure

Kanaya, Tomomitsu; Ueno, Takayoshi; Terabe, Masaki; Kido, Takashi; Okuda, Naoki; Araki, Kazuhiro; Watanabe, Takuji; Toda, Köichi; Kuratani, Toru; Sawa, Yoshiki

doi:10.1007/s00246-019-02108-0

Cited by 9 publications

(7 citation statements)

References 13 publications

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“…The severely decompensated infant was successfully switched from ECMO to a durable ventricular assist device and underwent transplantation safely. Frequent cerebrovascular complications have been reported with the Berlin Heart EXCOR (Berlin Heart GmbH) [10]. In this case, the patient received warfarin and dual antiplatelet therapy, and was free of any neurologic events.…”

Section: Kjtcvsmentioning

confidence: 88%

The First Pediatric Heart Transplantation Bridged by a Durable Left Ventricular Assist Device in Korea

Shin

Park

Jung

et al. 2020

Korean J Thorac Cardiovasc Surg

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Treatment options for children with end-stage heart failure are limited. We report the first case of a successful pediatric heart transplantation bridged with a durable left ventricular assist device in Korea. A 10-month-old female infant with dilated cardiomyopathy and left ventricular non-compaction was listed for heart transplantation. During the waiting period, the patient's status deteriorated. Therefore, we decided to provide support with a durable left ventricular assist device as a bridge to transplantation. The patient was successfully bridged to heart transplantation with effective support and without any major adverse events.

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Section: Kjtcvsmentioning

confidence: 88%

The First Pediatric Heart Transplantation Bridged by a Durable Left Ventricular Assist Device in Korea

Shin

Park

Jung

et al. 2020

Korean J Thorac Cardiovasc Surg

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“…b Computed tomography confirmed diaphragmatic hernia small patients [5] and may function as a bridge to transplantation or recovery [6]. The waiting period for heart transplantation is longer in Japan than the global average because of the severe shortage of organ donations for children, so the duration of LVAD implantation may be unavoidably long [1,7].…”

Section: Discussionmentioning

confidence: 99%

“…Left ventricular assist devices (LVADs) have become popular in children with the advent of the Berlin Heart EXCOR® (BHE) VAD (Berlin Heart, Inc., The Woodlands, TX, USA). The BHE VAD provides long-term circulatory support for pediatric patients with severe heart failure, not only functioning as a bridge to transplantation but also facilitating the successful weaning off of a VAD [ 1 ]. Although advances in VAD technology and clinical management have resulted in improved outcomes of pediatric heart failure, VADs are associated with potential risks of neurologic, hematologic, gastrointestinal, and immunologic complications [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Thoracoscopic repair of diaphragmatic hernia following ventricular assist device implantation

et al. 2020

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Background: Diaphragmatic hernia is a rare complication of ventricular assist device (VAD), mainly developing after explantation of the device. We herein report a case of diaphragmatic hernia that developed following the implantation of VAD. Case presentation: A 4-month-old girl with a diagnosis of dilated cardiomyopathy underwent VAD implantation for a bridge to heart transplantation. Three months later, intermittent vomiting developed, and left-sided diaphragmatic hernia was confirmed on plain X-ray and computed tomography. Without any findings of ischemia, we performed elective thoracoscopic repair of the diaphragmatic hernia. In the right decubitus position, thoracoscopy revealed the small intestine to be herniated into the left thorax. After reduction of the herniated intestine, the defect of the diaphragm (3 × 2 cm in size) was directly closed with interrupted non-absorbable sutures. Her postoperative course was uneventful. Conclusion: Thoracoscopic repair of diaphragmatic hernia associated with VAD implantation may be a safe approach.

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“…There were 41 857 articles identified with the search strategy, of which 14 3,5,9,[22][23][24][25][26][27][28][29][30][31][32] were kept in the final review (Figure 1). Within these studies, with data ranging from 1990 to 2020, 58 hospitals in North America, Europe, Australia, and Asia supported 984 children with BHE (Table 1).…”

Section: Overall Study Populationmentioning

confidence: 99%

Successful explantation of children from the Berlin Heart EXCOR® ventricular assist device: A systematic review

Mikulski,

Iyer,

Well

et al. 2024

Artificial Organs

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BackgroundThe Berlin Heart EXCOR® (BHE) can bridge children with severe heart failure to transplantation, but some are successfully weaned and spared transplantation. This study seeks to identify characteristics of children amenable to successful explantation with BHE support.MethodsPreferred Reporting Items for Systematic reviews and Meta‐Analyses 2020 guidelines were used. Five databases were screened for original, English articles measuring BHE support in patients <18 years old based on title and abstract. Exclusion criteria were applied: full‐text availability, <10 total pediatric BHE patients, zero successful explantations from BHE, nonprimary literature, adult and pediatric results that could not be separated, and studies with overlapping patient information. Studies were analyzed with descriptive statistics.ResultsFrom 41 857 potential studies, 14 were analyzed with data from 58 hospitals on four continents from 1990 to 2020. There were 984 BHE patients. The most common diagnosis was dilated cardiomyopathy (n = 318, 32.3%), followed by congenital heart disease (n = 249, 25.3%). There were 85 (8.6%) children explanted with favorable outcomes. The underlying diagnosis was known in 44 (51.8%) cases: 14 (8.4%) of 166 cardiomyopathies, 17 (48.6%) of 35 myocarditis, and 12 (16.7%) of 72 with congenital heart disease were explanted. When the type of support was known, the rate of LVAD patients explanted was 21.3% (n = 19/89) and 2.4% (n = 1/42) of BiVAD patients were explanted.ConclusionExplantation from BHE is not uncommon at 8.6%, but significant variation exists in the explantation data reported. Myocarditis and LVAD support may be populations suitable for weaning. Standardization of reporting measures and prospective registries may help identify patients suitable for this alternative to transplant and help develop weaning protocols.

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Impact of Long-Term Support with Berlin Heart EXCOR® in Pediatric Patients with Severe Heart Failure

Cited by 9 publications

References 13 publications

The First Pediatric Heart Transplantation Bridged by a Durable Left Ventricular Assist Device in Korea

The First Pediatric Heart Transplantation Bridged by a Durable Left Ventricular Assist Device in Korea

Thoracoscopic repair of diaphragmatic hernia following ventricular assist device implantation

Successful explantation of children from the Berlin Heart EXCOR® ventricular assist device: A systematic review

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